P-017 Analysis of microRNA expression in Gastroenteropancreatic Neuroendocrine Tumor

Neira, Sara; Carvajal, Maria; Herrera, Larry; Pérez, Rolando; Panqueva, Rocío López

doi:10.1093/annonc/mdw199.17

Cited by 1 publication

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“…Gene silencing by miRNAs governs diverse physiological and pathological steps, which can be used in various cancer classifications as informative tissue markers [ 20 ]. However, studies on miRNA expression profiles in NETs have yielded conflicting results [ 21 , 22 , 23 , 24 ], making it challenging to identify key tissue markers [ 25 ]. For example, a previous study discovered that miR-885-5p could be an early prognostic indicator for LVI in rectal NETs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…A more recent study in Japan examined seven rectal NET tissues and found overexpression of the miR-144/miR-451 cluster in NETs of grade 1 with LVI [ 22 ]. In another study, higher expression of miR-19a and miR-96 was found in metastatic tissue than in primary tumors of the small intestine and colon; however, the sample size was limited [ 23 ]. A meta-analysis of 22 studies found inconsistent miRNA signatures in gastric, pancreatic, small intestinal, and colorectal NETs [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Different miRNAs Related to FBXW7 Mutations or High Mitotic Indices Contribute to Rectal Neuroendocrine Tumors: A Pilot Study

Kang

Park

Lim

et al. 2023

IJMS

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Recent studies suggest that miRNA may be involved in the development of rectal neuroendocrine tumors (NETs). We explored the frequency of clinicopathologically relevant mutations and miRNA expression in rectal NETs to examine molecular profiles related to prognosis and behavior. Twenty-four eligible specimens with endoscopically excised rectal NETs were selected. Next-generation sequencing and an miRNA expression assay were used to evaluate the expression profile relevant to common genetic mutations in rectal NETs. Kyoto Encyclopedia of Genes and Genomes analysis predicted that the possible target signaling pathways were correlated with dysregulated miRNAs. Nineteen rectal NETs harbored more than one mutation in the 24 cancer-related genes. Seven miRNAs (hsa-miR-769-5p, hsa-miR-221-3p, hsa-miR-34a-5p, hsa-miR-181c-5p, hsa-miR-1246, hsa-miR-324-5p, and hsa-miR-361-3p) were significantly down-regulated in tumors harboring the FBWX7 mutation. Unsupervised hierarchical clustering analysis showed that up-regulation of these seven miRNAs may result in high mitotic indices, indicating the role of miRNAs in tumor progression. Among the down-regulated miRNAs, hsa-miR-769-5p was strongly correlated with extracellular matrix–receptor interaction and lysine degradation. Among the clinicopathological factors, up-regulated hsa-miR-3934-5p was linked to an increased mitotic count. No change in miRNA expression was associated with a tumor size >1 cm, lymphovascular invasion, or Ki-67 index. In summary, we identified different miRNA signatures involved in FBXW7 mutations or high mitotic indices in rectal NETs, which may play a critical role in tumor behavior.

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