Ozone Therapy in the Management and Prevention of Caries

AlMogbel, AbdulMajeed A; Albarrak, Maram I; AlNumair, Shahad F

doi:10.7759/cureus.37510

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…By interacting with the immune system, ozone therapy exerts a range of effects, including the activation of immune responses, regulation of cytokine production, and modulation of inflammatory processes. 3 , 28 The effects of ozone on macrophages, T cells, B cells, NK cells, and dendritic cells can be used in the treatment of infectious diseases, autoimmune disorders, and cancer immunotherapy. 1 In clinical use, ozone therapy not only increases leukocyte activity and the immunoglobulin G (IgG) level in patients with selective immunoglobulin A deficiency, 29 but ozone has also been shown to increase the production of both IL-8 and tumor necrosis factor alpha (TNF-α) in a human monocytic cell line (THP-1 cell) model.…”

Section: Mechanism Of Ozone Therapymentioning

confidence: 99%

“…Ozone has been proposed for use in treating various pathologies. 3 In medical care, ozone therapy, which has been used for almost 60 years, 4 acts by exerting controlled levels of oxidative stress produced by ozone reactions that promote the upregulation of the antioxidant system and boost the immune system. 5 - 7 It involves the administration of ozone, an allotrope of oxygen, to the body.…”

Section: Introductionmentioning

confidence: 99%

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Ozone Therapy for Breast Cancer: An Integrative Literature Review

Li,

2024

Integr Cancer Ther

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Breast cancer is the most prevalent form of cancer in women. Despite significant advances in conventional treatment, additional safer complementary treatment options are needed. Recently, ozone therapy has been considered as a type of medical adjunctive treatment that could inhibit cancer cell survival and reduce chemoresistance. However, only a few studies have been conducted on its use in breast cancer, and the optimal dosage and time of administration are unknown. Currently, preclinical studies suggest that ozone alone or in combination with chemotherapy is an effective method for inhibiting breast cancer cell growth. However, rather than investigating the effects of ozone as an antitumor therapy, current clinical trials have generally assessed its effect as an adjunctive therapy for reducing chemotherapy-induced side effects, increasing oxygen tension, normalizing blood flow, restoring blood lymphocytes more rapidly, and reducing fatigue symptoms. In this article, the use of ozone as a medical adjunctive treatment for breast cancer and its role in integrative therapy are summarized and discussed.

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Section: Mechanism Of Ozone Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Li,

2024

Integr Cancer Ther

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In Vitro Antibacterial Effect of Ozonated Solutions on Enterococcus faecalis and Pseudomonas aeruginosa

Quispe-Quispe,

Cruz,

Quispe-Maquera

2024

Smart Innovation, Systems and Technologies

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Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats

de Medeiros Cardoso,

Ervolino,

Miyasawa

et al. 2024

BioMed Research International

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This study sought to examine the effects of systemic ozone (O3) treatment on the healing of skin wounds induced on the dorsal surface of Wistar rats. The skin wounds were created using a 10 mm round punch following the sagittal medial plane in 72 rats. Then, the animals were randomly assigned to four groups, each receiving the following treatments: group C, which did not undergo treatment with the O3/O2 mixture; group OZ0.3, administered the O3/O2 mixture at a dose of 0.3 mg/kg; group OZ0.7, given the O3/O2 mixture at a dose of 0.7 mg/kg; and group OZ1.0, provided with the O3/O2 mixture at a dose of 1.0 mg/kg. Six animals from each group were euthanized at 7, 14, and 21 days postoperatively. Clinical, histological, histometric, and immunohistochemical (IHC) analyses were accomplished. Data from clinical and histometric assessments revealed that OZ0.7 and OZ1.0 demonstrated more favorable healing, with greater wound contraction observed in the OZ1.0 group at 14 and 21 days. Histologically, the OZ1.0 group exhibited aspects consistent with an accelerated tissue repair process. IHC analysis revealed greater vascular endothelial growth factor (VEGF) immunostaining in the OZ0.7 (7 days) and OZ1.0 (7 and 14 days) groups compared to the C group. Expression of transforming growth factor beta‐1 was significantly increased in the OZ0.7 (14 days) and OZ1.0 (7 and 14 days) groups compared to the C group. In conclusion, our data suggest that systemic use of O3 enhanced tissue repair in cutaneous wounds in a dose‐dependent manner, with concentrations of 1.0 mg/kg providing the most beneficial effects. Furthermore, the results of this study implicate the use of O3 for the treatment of skin wounds aiming at improving the healing process over time. Our findings suggest the use of O3 as a viable alternative to enhance wound healing and repair.

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Ozone Therapy in the Management and Prevention of Caries

Cited by 6 publications

References 23 publications

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Ozone Therapy for Breast Cancer: An Integrative Literature Review

In Vitro Antibacterial Effect of Ozonated Solutions on Enterococcus faecalis and Pseudomonas aeruginosa

Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats

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