Ozone Therapy in Refractory Pelvic Pain Syndromes Secondary to Cancer Treatment: A New Approach Warranting Exploration

Clavo, Bernardino; Navarro, Minerva; Federíco, M.; Borrelli, Emma; Jorge, Ignacio J; Ribeiro, Ícaro José Santos; Rodríguez-Melcón, J.I.; Caramés, Miguel A.; Santana‐Rodríguez, Norberto; Rodrı́guez-Esparragón, Francisco

doi:10.1089/jpm.2019.0597

Cited by 8 publications

(17 citation statements)

References 26 publications

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“…Pain level, according to the Visual Analog Scale (VAS) was 7.8 ± 2.1 before the commencement of ozone therapy by local and rectal insufflation. There was a significative (p < 0.05) and clinically relevant decrease (>5 points in VAS) pain reduction after the first three months of ozone treatment [82], at the end of treatment, and nine months after the end of ozone therapy. Five of six patients were able to decrease or even discontinue analgesic intake requirements [83].…”

Section: Ozone Therapy In Chemotherapy-induced Neurologic Symptoms Anmentioning

confidence: 87%

“…Finally, we describe our experience in a small group of patients with chronic neuropathic pelvic pain secondary to cancer treatments (chemotherapy, radiotherapy, and surgery) [82,83]. In this group, cancer treatment included radiotherapy in five patients, chemotherapy in four, and surgery in two.…”

Section: Ozone Therapy In Chemotherapy-induced Neurologic Symptoms Anmentioning

confidence: 99%

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Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Clavo

Martı́nez-Sánchez²,

Rodrı́guez-Esparragón

et al. 2021

IJMS

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(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of CIPN. (2) Methods: The aims of this works are: (a) to summarize the potential mechanisms that could induce CIPN by the most relevant drugs (platinum, taxanes, vinca alkaloids, and bortezomib), with particular focus on the role of oxidative stress; (b) to summarize the current situation of prophylactic and treatment approaches; (c) to describe the action mechanisms of ozone therapy to modify oxidative stress and inflammation with its potential repercussions for CIPN; (d) to describe related experimental and clinical reports with ozone therapy in chemo-induced neurologic symptoms and CIPN; and (e) to show the main details about an ongoing focused clinical trial. (3) Results: A wide background relating to the mechanisms of action and a small number of experimental and clinical reports suggest that ozone therapy could be useful to prevent or improve CIPN. (4) Conclusions: Currently, there are no clinically relevant approaches for the prevention and treatment of stablished CIPN. The potential role of ozone therapy in this syndrome merits further research. Randomized controlled trials are ongoing.

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Section: Ozone Therapy In Chemotherapy-induced Neurologic Symptoms Anmentioning

confidence: 87%

Section: Ozone Therapy In Chemotherapy-induced Neurologic Symptoms Anmentioning

confidence: 99%

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Clavo

Martı́nez-Sánchez²,

Rodrı́guez-Esparragón

et al. 2021

IJMS

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“…Ozone for medical use consists of a gas mixture of O3 and O2, obtained from medical-grade oxygen using an ozone generator device that has to be administered in situ because of its short half-life. Ozone is used in a broad spectrum of diseases such as infection (14), neuropathic pain (15)(16)(17), and posttreatment adhesion formation (18). Oxidative stress, inflammation, and ischemia/hypoxia are the principal mechanisms involved in pain (17).…”

mentioning

confidence: 99%

“…Ozone is used in a broad spectrum of diseases such as infection (14), neuropathic pain (15)(16)(17), and posttreatment adhesion formation (18). Oxidative stress, inflammation, and ischemia/hypoxia are the principal mechanisms involved in pain (17). The previous studies demonstrated that ozone can favorably modify those processes for the resolution of zoster-associated pain, complex regional pain syndrome, and refractory pelvic pain syndromes secondary to cancer treatment (15)(16)(17).…”

mentioning

confidence: 99%

“…Oxidative stress, inflammation, and ischemia/hypoxia are the principal mechanisms involved in pain (17). The previous studies demonstrated that ozone can favorably modify those processes for the resolution of zoster-associated pain, complex regional pain syndrome, and refractory pelvic pain syndromes secondary to cancer treatment (15)(16)(17). It has been in continuous medical use for over 100 years, having been used by German soldiers in the trenches to disinfect wounds in World War I (14)(15)(16)(17)(18)(19)(20).…”

mentioning

confidence: 99%

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Feasibility of Ultrasound-Guided Peritoneal Perfusion with Ozone in the Treatment of Chronic Pelvic Pain: A Bicenter Retrospective Analysis

Zhang¹,

Qian

et al. 2021

Pain Phys

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Background: Numerous therapies have been developed for the treatment of chronic pelvic pain (CPP). Oxygen-ozone therapy is a new method for the treatment of CPP. Objectives: This article evaluated the feasibility of ultrasound-guided peritoneal perfusion with ozone in patients with CPP. Study Design: This is a bicenter retrospective study. Setting: The study was conducted at 2 pain centers of a university hospital. Methods: The medical records of patients with CPP (n = 60) from March 2016 until October 2018 were collected and reviewed. Group A contained 19 patients who were treated with a 1500 mcg dose of ozonated water (10 mcg/mL concentration and 150 mL volume), group B contained 23 patients using the same dose of ozonated water but a 15 mcg/mL concentration and 100 mL volume. Group C included 18 patients using a similar ozone dose but delivered in an oxygen-ozone mixture (15 mcg/mL concentration and 100 mL volume oxygen-ozone mixture). Visual Analog Scale (VAS) scores for pain of the 3 groups were compared at pretreatment, posttreatment, 1, 3, and 6 months posttreatment. The injection pain was evaluated using a 4-point verbal rating scale. Quality of life (QoL), anxiety, and depression were assessed at pretreatment and at 6 months posttreatment. Results: The VAS scores of the 3 groups decreased over time following treatment. Group A showed much higher pain scores compared with groups B and C at 1, 3, and 6 months posttreatment. However, the injection pain for groups B and C was higher than group A, but there was no difference seen between group B and C. At 6 months posttreatment, the QoL for all patients improved compared with pretreatment, whereas the anxiety and depression did not demonstrate differences. Limitations: The main limitations of this study are the retrospective study design, limited case number, and short follow-up period. Conclusions: Ultrasound-guided peritoneal perfusion with ozone is a feasible therapy for patients with CPP. Key words: Chronic pelvic pain, ozone, peritoneal perfusion

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Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial

Clavo

Robaina

Urrútia

et al. 2021

Complementary Therapies in Medicine

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Ozone Therapy in Refractory Pelvic Pain Syndromes Secondary to Cancer Treatment: A New Approach Warranting Exploration

Cited by 8 publications

References 26 publications

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

Feasibility of Ultrasound-Guided Peritoneal Perfusion with Ozone in the Treatment of Chronic Pelvic Pain: A Bicenter Retrospective Analysis

Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial

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