Ozone Therapy and Its Use in Medicine

Re, Lamberto; Rowen, Robert Jay; Travagli, Valter

doi:10.1159/000443604

Cited by 9 publications

(10 citation statements)

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“…Ozone (O 3 ) is a molecule that was discovered in the mid‐19th century (Re, Rowen, & Travagli, ). It has a cyclic structure consisting of three atoms of oxygen that is normally present as a gas.…”

Section: Introductionmentioning

confidence: 99%

“…Since then, the therapeutic use in medicine has been extended to a large number of diseases. The gas administered in precise therapeutic doses is used to disinfect and treat diseases due to its antimicrobial ability, stimulation of oxygen metabolism and activation of the immune system (Re et al, ). However, ozone also has the potential to react and oxidize organic compounds and, when present as an air pollutant, can cause harmful effects on the respiratory tract (Bell, Zanobetti, & Dominici, ).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain

Braidy

Izadi

Sureda

et al. 2017

Journal Cellular Physiology

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Ozone, one of the most important air pollutants, is a triatomic molecule containing three atoms of oxygen that results in an unstable form due to its mesomeric structure. It has been well-known that ozone has potent ability to oxidize organic compounds and can induce respiratory irritation. Although ozone has deleterious effects, many therapeutic effects have also been suggested. Since last few decades, the therapeutic potential of ozone has gained much attention through its strong capacity to induce controlled and moderated oxidative stress when administered in precise therapeutic doses. A plethora of scientific evidence showed that the activation of hypoxia inducible factor-1α (HIF-1a), nuclear factor of activated T-cells (NFAT), nuclear factor-erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE), and activated protein-1 (AP-1) pathways are the main molecular mechanisms underlying the therapeutic effects of ozone therapy. Activation of these molecular pathways leads to up-regulation of endogenous antioxidant systems, activation of immune functions as well as suppression of inflammatory processes, which is important for correcting oxidative stress in diabetes and spinal pain. The present study intended to review critically the available scientific evidence concerning the beneficial properties of ozone therapy for treatment of diabetic complications and spinal pain. It finds benefit for integrating the therapy with ozone into pharmacological procedures, instead of a substitutive or additional option to therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain

Braidy

Izadi

Sureda

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Therefore, he concluded that metabolic interventions should be directed to decrease the release of free fatty acids from adipose tissue and enhance myocardial glycolytic activity during a myocardial infarction. This article mentioned by Re et al [1] did not demonstrate that a fatty meal causes myocardial infarction, whereas it clearly ascertained that increased free fatty acid release during myocardial infarction has a negative influence on the prognosis of myocardial infarction. Thus, indicating a fatty meal as an important potential risk factor of myocardial infarction in patients without conventional risk factors seems again invalid.…”

mentioning

confidence: 95%

“…We would like to thank Re et al [1 ]for their contribution and comments on our article entitled ‘Myocardial infarction after ozone therapy: is ozone therapy Dr. Jekyll or Mr. Hyde?'…”

mentioning

confidence: 99%