Ozone preconditioning attenuates contrast-induced nephropathy in rats

Kurtoğlu, Tünay; Durmaz, Selim; Akgüllü, Çağdaş; Güngör, Hasan; Eryılmaz, Ufuk; Meteoğlu, İbrahim; Karul, Aslıhan; Boğa, Mehmet

doi:10.1016/j.jss.2015.01.041

Cited by 20 publications

(18 citation statements)

References 42 publications

(39 reference statements)

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“…Therefore, we speculate that preconditioning with ozone may have a beneficial impact against acute mechanisms initiating injury associated with contrast agent. This finding is consistent with the data supporting that ozone pretreatment activates renal antioxidant mechanisms potently 25 . On the other hand, prolonged course of ozone treatment after contrast agent is given may alleviate the histopathologic injury.…”

Section: ■ Discussionsupporting

confidence: 93%

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An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

et al. 2018

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Section: ■ Discussionsupporting

confidence: 93%

“…Kurtoglu et al 25 suggested that reduction of the oxidative stress in the animals exposed to contrast agents was linked with enhancement of the renal antioxidant systems and increased endogenous capacity for ROS scavenging. In the literature, there is contradictory data on the beneficial effect of NAC for prevention of CIN.…”

Section: ■ Discussionmentioning

confidence: 99%

An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

et al. 2018

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“…[25][26][27] Moreover, low blood flow in the medulla, which has a high demand for oxygen, might result from increased perivascular hydrostatic pressure, high viscosity, or changes in vasoactive substances such as endothelin, NO, and adenosine. 28,29 Furthermore, contrast agents have direct toxic effects on kidney tubular cells, inducing vacuolization, change in mitochondrial function, and even apoptosis. 28,30 In this study, CIN significantly increased denudation of tubular cells, tubule dilatation and intratubular obstruction by granular casts, but subsided following administration of 2 and 10 lM SPC.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats

Aksu

Unlu

et al. 2016

Renal Failure

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Contrast induced nephropathy (CIN) is a major cause of morbidity, and increased costs as well as an increased risk of death. This study was evaluated effects of exogenous sphingosylphosphorylcholine (SPC) administration on CIN in rats. Eight animals were included in each of the following eight groups: control, control phosphate-buffered solution (PBS), control SPC 2, control SPC 10, CIN, CIN PBS, CIN SPC 2 and CIN SPC 10. The induced nephropathy was created by injected with 4 g iodine/kg body weight. SPC was administered 3 d at a daily two different doses of 2 μm/mL and 10 μm/mL intraperitoneally. The severity of renal injury score was determined by the histological and immunohistochemical changes in the kidney. Malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) were determined to evaluate the oxidative status in the renal tissue. Treatment with 2 and 10 μM SPC inhibited the increase in renal MDA, NO levels significantly and also attenuated the depletion of SOD in the renal injuryCIN. These data were supported by histopathological findings. The inducible nitric oxide synthase positive cells and apoptotic cells in the renal tissue were observed to be reduced with the 2 and 10 μM SPC treatment. These findings suggested that 2 and 10 μM doses can attenuate renal damage in contrast nephropathy by prevention of oxidative stress and apoptosis. The low and high dose SPC may be a promising new therapeutic agent for CIN.

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“… Histopathologic evaluation : reduction in degeneration of tubular epithelium, dilatation of Bowman capsule, necrosis in tubular epithelium, vascular congestion. ( Kurtoglu et al, 2015 ) Preconditioning : 1 mg/kg, rectal insufflations, 15 applications, once a day, before ischemia/reperfusion and/or ischemic preconditioning. Reduction : malondialdehyde (MDA), urea nitrogen (BUN), creatinine (Cr), Jablonski grading scale scores.…”

Section: Effect Of Ozone Oxidative Preconditioning On Oxidative Stresmentioning

confidence: 99%

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Scassellati

Galoforo

Bonvicini

et al. 2020

Ageing Research Reviews

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Highlights Aging and neurodegenerative diseases are characterized by complex and multifactorial aetiology and challenges regarding treatments efficacy and costs persist. Oxygen-ozone (O 2 -O 3 ) therapy is a non-invasive, non-pharmacological, low cost and no-side effect procedure based on antioxidant capacity of O 3 . A plethora of scientific evidence supports other crucial properties of O 3 in physiopathological processes. Nrf2 is one of the principal molecular signalling on which O 3 exercises its antioxidant/anti-apoptotic/pro-autophagy effects, involved in aging and in neurodegenerative disorders. This review provides a consistent rationale to implement future clinical studies to apply the O 2 -O 3 treatment along with other antioxidants (polyphenols, mushrooms) in aging and in neurodegeneration.

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Ozone preconditioning attenuates contrast-induced nephropathy in rats

Cited by 20 publications

References 42 publications

An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

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