Ozone-enhanced TiO2 nanotube arrays for the removal of COVID-19 aided antibiotic ciprofloxacin from water: Process implications and toxicological evaluation

Abromaitis, Vytautas; Svaikauskaite, J.; Šulčiūtė, Agnė; Sinkeviciute, D.; Žmuidzinavičienė, Nerita; Misevicius, S.; Tichonovas, Martynas; Urniežaitė, Inga; Jankūnaitė, Dalia; Urbonavičius, Marius; Varnagiris, Šarūnas; Dzingeleviciene, R.; Baranauskis, K.; Martuzevicius, D.

doi:10.1016/j.jenvman.2022.115515

Cited by 15 publications

(2 citation statements)

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“…Due to their non-selective nature, OH• can degrade various organic compounds present in water and wastewater, forming carbon dioxide, water, and mineral acids (Legrini et al, 1993). The most used AOPs include ozonebased processes (Abromaitis et al, 2022), Fenton reaction (Im et al, 2015a), advanced oxidation with persulfate (Ge et al, 2021), and photocatalysis (Ye et al, 2018). Among these, the photocatalytic process using a semiconductor material has been extensively researched for the elimination, degradation, and mineralization of organic compounds in aqueous systems (Li and Li, 2001;Choi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic degradation of naproxen using TiO2 single nanotubes

Sepúlveda,

Musiał,

Saldan

et al. 2024

Front. Environ. Chem.

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Herein, TiO2 single-tube (TiO2 ST-NT) powders with and without magnetite Fe3O4 nanoparticles (TiO2 ST-NT@Fe3O4NPs) are presented for the first time as excellent photocatalysts for the degradation of one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs), naproxen (NPX). The TiO2 ST-NT powders were synthesized by anodization followed by etching of the double wall, bending, sonication, ultra-centrifugation, and finally annealing at 600°C. A part of the obtained TiO2 ST-NT powders was decorated with Fe3O4 nanoparticles using a simple one-step decoration process. The best photocatalytic performance of TiO2 ST-NT and TiO2 ST-NT@Fe3O4NPs powders was obtained under the white light (6.2 × 10−4 s-1) and the blue light (2.7 × 10−4 s-1), respectively. During NPX photodegradation using TiO2 ST-NT powders, three main NPX transformation products (P1, P2, and P3) were detected. Upon excitation with the blue light illumination, TiO2 ST-NT@ Fe3O4NPs powders exhibited higher performance (∼80%) than TiO2 ST-NT powders (∼23%) within 1 h, resulting in an approximately three times increased photocatalytic rate constant. Moreover, under simulated sunlight conditions, TiO2 ST-NT powders demonstrated remarkable activity, achieving a 94% NPX degradation within 1 h. TiO2 ST-NT and TiO2 ST-NT@Fe3O4NPs powders represent excellent photocatalysts for NPX degradation.

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Section: Introductionmentioning

confidence: 99%

Photocatalytic degradation of naproxen using TiO2 single nanotubes

Sepúlveda,

Musiał,

Saldan

et al. 2024

Front. Environ. Chem.

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“…Accumulation of antibiotics in the environment brings about potential adverse effects on human health. − In particular, fluoroquinolone (FQ) antibiotics are extensively used in human and veterinary infections, especially during the COVID-19 pandemic. − Traditional water treatment processes are ineffective in removing these antibiotics. , FQs have therefore been detected in many water environments, with concentrations ranging from nanograms to micrograms per liter . FQs can pose potential risks. − The median effective concentrations (EC 50 ’s) of levofloxacin (LEV), enrofloxacin (ENR), and flumequine (FLU) were 3.13, 7.18, and 15.11 mg/L based on the toxicity to the neonatal or embryonic of D. magna .…”

Section: Introductionmentioning

confidence: 99%

Fe(V) Dominates the Toxicity Increase Pathway during Ferrate(VI) Degradation of Fluoroquinolone Antibiotics

Wang

Jiang

et al. 2023

ACS EST Eng.

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Environmental accumulation of fluoroquinolones (FQs) has brought concerns over their potential risks to human health. This study found that ferrate (Fe(VI)) could efficiently degrade norfloxacin (NOR), ciprofloxacin (CIP), and levofloxacin (LEV). However, cytotoxicity to mammalian cells of NOR, CIP, and LEV dramatically increased from 9. 41, 8.34, and 11.05 mg phenol/L to 20.76, 26.13, and 32.45 mg phenol/L after reacting with Fe(VI) for 3 min. Intracellular oxidative stress in the mammalian cells also increased, suggesting the risk of applying Fe(VI) for FQ degradation. Fe(V) was demonstrated to play the major role in FQ degradation by kinetics investigation, probe contaminant (PMSO and 2,2′-azino-bis-(3-ethylbenzothiazoline-6sulfonate) (ABTS)), and pyrophosphate competing experiments. Density functional theory (DFT) calculation and toxicity prediction suggested that, in the CIP-ferrate system, Fe(V) increased the toxicity via oxidizing the piperazine group to −NH 2 . In the NOR-ferrate and LEV-ferrate systems, Fe(V) mainly attacked the quinolone ring. The unstable products underwent subsequent carboxylation or hydroxylation, leading to the further increased toxicity. The current research on micropollutant removal focused on applying various approaches to activate ferrate to generate high-valent iron intermediates with stronger oxidizing capacity. Our study gave a risk warning that high-valent iron intermediates might play an important role in increasing the toxicity of micropollutants.

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