Ozone and Human Blood

Buckley, Ramon D.; Hackney, Jack D.; Clark, Kenneth W.; Posin, Clara I.

doi:10.1080/00039896.1975.10666631

Cited by 126 publications

(45 citation statements)

References 19 publications

(1 reference statement)

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“…This adaptation process may explain the changes in RBC aggregation and fragility with extended ozone application; but there was no adaptation in RBC deformability (Artis et al, 2010). It was also observed that 15 days after single dose of ozone application its effect on RBC deformability still persist but lessened (Buckley et al, 1975). Thus when talking about RBC deformability it can be said that there is either a later developing adaptation or it does not exist at all.…”

Section: Hemorheological Effects Of Ozone Treatmentmentioning

confidence: 79%

How Ozone Treatment Affects Erythrocytes

Aydoğan¹,

Artis²

2012

Hemodynamics - New Diagnostic and Therapeutic Approaches

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Section: Hemorheological Effects Of Ozone Treatmentmentioning

confidence: 79%

How Ozone Treatment Affects Erythrocytes

Aydoğan¹,

Artis²

2012

Hemodynamics - New Diagnostic and Therapeutic Approaches

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“…Although elevated blood levels of some enzymes are indicative of tissue injury, and most authors tend to explain their findings to be those of an injurious nature, one may question whether the possibility of adaptation has been sufficiently taken into account, as was done by Buckley et al (8) and Hackney et al (9).…”

Section: Methodsmentioning

confidence: 93%

“…Even more so, since nonanthropogenic 03 is a natural ambient constituent for which an adaptive mechanism to lower values might be supposed to be present. Currently, such a mechanism has actually been suggested in the results of a number of studies, including those done in man (8)(9)(10)(11).…”

mentioning

confidence: 99%

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Veninga¹,

Wagenaar²,

Lemstra³

1981

Environmental Health Perspectives

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Short-term exposure of mice to low 03 doses, as defined by the product of concentration and exposure time (ct), was observed to induce alterations in two enzyme systems: first, that leading to changes in hepatic reduced ascorbic acid (RAA) content, and second to changes in plasma creatine phosphokinase (CPK) activity. RAA alterations were noticed immediately, 30 min and 120 min after termination of the exposure period, whereas CPK showed alterations immediately and 15 min after termination of the exposure. Later determinations, i.e., 24 hr after 03 exposure for RAA and 30 min after 03 exposure for CPK, revealed no significant differences when compared to control animals. Although differences in sensitivity existed, the dose response curves for both systems were more or less similar, showing a short decrease for the initial very low 03 doses, followed by a profound rise and a gradual decrease to control levels for subsequent ct doses. Exceptions were the 30 min curve for RAA and the immediate curve for CPK in so far as that both showed an additional depression.Neither plasma histamine nor plasma lactic acid dehydrogenase (LDH3) were observed to be altered by the range of 03 doses employed. These findings were explained on the basis of adaptation of the organism to a potentially noxious 03 stimulus by enhanced metabolic processes: a weak stimulus leading to only a small adjustment, and stronger stimuli to elevated enzyme activity as well. With increasing doses of 03 this elevation in enzyme activity was found to be gradually diminished, possibly due to a steadily growing demand, leaving the overshoot becoming continually smaller until a balanced state is achieved.Radiomimetic activity of ozone (03), first described by Brinkman and Lamberst (1) (5, 6). In the opinion of these authors there is no threshold value (no-effect level), and the dose-effect curve starts at zero. However, in the same way as with ionizing irradiation, in order to visualize effects, dosages of 03 have to be explored which in general clearly exceed the permissible

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“…The vertical axis represents GSH levels in mg%o. Normal individuals not under stress have GSH levels ranging from 53 to 84 mgo (15), while G-6-PD deficient individuals under similar nonstress conditions have approximately 70o the GSH of normal individuals with a range of 38 to 51 mg% (16). When testing for the occurrence of a G-6-PD deficiency the individual is often given a GSH stability test.…”

Section: Ozonementioning

confidence: 99%