Oyster oligopeptide improving cyclophosphamide‐induced partial androgen deficiency of the aging male by promotion of testosterone synthesis

Abstract

Aim The aim of this study was to investigate the effect of oyster oligopeptide (OOP) at different doses on testosterone secretion and its regulating mechanism in partial androgen deficiency syndrome of aging male. Methods The cyclophosphamide‐induced partial androgen deficiency syndrome of the aging male rats were treated with a low, medium and high dose of OOP for 6 weeks. Results Cyclophosphamide could decrease levels of total testosterone and luteinizing hormone in serum, and testosterone and glutathione peroxidase in testis, and increase malondialdehyde, and downregulate the mRNA expression of steroidogenic acute regulatory protein, steroidogenic acute regulatory‐related lipid transfer domain 7 and P450 cholesterol side chain cleavage enzyme in testis (P < 0.05). All these changes were reversed by OOP co‐administration with different doses, although, OOP at a low dose did not increase serum testosterone, luteinizing hormone and testicular glutathione peroxidase levels. Conclusions OOP treatment with different doses can effectively reduce oxidative stress in testicular tissue, promote the synthesis of testosterone and then prevent the formation of partial androgen deficiency syndrome of the aging male, with optimal effect at medium dose. Geriatr Gerontol Int 2021; 21: 268–275.

Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice

“…Oral administration of oyster meat hydrolysates by alcalase could induce aphrodisiac activities and consequently enhance the sexual behavior in normal male mice (Zhang et al, 2019). According to Jin et al, Opp can help the aged male with cyclophosphamide-induced partial androgen insufficiency by increasing testosterone production (Jin et al, 2021). Although hydrolyzed peptides from purple perilla (Perilla frutescens L.…”

Protective effects of oyster polypeptide on cyclophosphamide‐induced immunosuppressed rats

“…Six rats in each group were therefore selected for subsequent experiments. The rats in the HP (2 g kg −1 BW d −1 ), MP (1 g kg −1 BW d −1 ), and LP (0.5 g kg −1 BW d −1 ) groups were administered different doses of OP from day 4 onwards with oral gavage, 27 lasting 14 days. Rats in the LMS group were administered 40 mg levamisole hydrochloride per kg BW d −1 with oral gavage, lasting 14 days.…”

Bioactives From Marine Animals: Potential Benefits for Human Reproductive Health

“…Oysters contain various bioactive compounds, a great source of protein and trace elements such as zinc, taurine, which may support sexual development, sexual function, hormone production, and reproductive cells (Jin et al, 2021a;Hao et al, 2022). In recent years, research using animal models has confirmed that oyster peptides have a strong antioxidant effect and can stimulate testosterone secretion and enhance sexual function (Zhang et al, 2018;Chen et al, 2019b;Jin et al, 2021a).…”

“…Oysters contain various bioactive compounds, a great source of protein and trace elements such as zinc, taurine, which may support sexual development, sexual function, hormone production, and reproductive cells (Jin et al, 2021a;Hao et al, 2022). In recent years, research using animal models has confirmed that oyster peptides have a strong antioxidant effect and can stimulate testosterone secretion and enhance sexual function (Zhang et al, 2018;Chen et al, 2019b;Jin et al, 2021a). Remarkably, the treatment with a medium (1.2 g/kg bw) dose of oyster oligopeptide had positive effects on testosterone production by reducing OS in testis and preventing the formation of cyclophosphamide-induced partial androgen deficiency of ageing males (Jin et al, 2021a).…”

“…In recent years, research using animal models has confirmed that oyster peptides have a strong antioxidant effect and can stimulate testosterone secretion and enhance sexual function (Zhang et al, 2018;Chen et al, 2019b;Jin et al, 2021a). Remarkably, the treatment with a medium (1.2 g/kg bw) dose of oyster oligopeptide had positive effects on testosterone production by reducing OS in testis and preventing the formation of cyclophosphamide-induced partial androgen deficiency of ageing males (Jin et al, 2021a). According to Zhang et al (2021a), oyster peptide (in which >95% peptides were <3000 Da) from Crassostrea gigas can improve the serum testosterone and cyclic adenosine monophosphate (cAMP) in male mice.…”