Oyster mushroom (Pleurotus ostreatus) reduces the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat liver microsomes

Bobek, P; Hromadová, M; Ozdín, L

doi:10.1007/bf02128749

Cited by 32 publications

(30 citation statements)

References 21 publications

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“…In another study, dietary fiber extracted from P. cornucopiae had a marked antiatherosclerotic effect in vitro, and patients with coronary disease showed a decreased atherogenic activity (20-40%) in their sera after the consumption of this mushroom, which confirms that it has a natural cholesterol-lowering agent that is responsible for this hypocholesterolemic effect (Ryong et al, 1989). Addition of 1-5% of oyster mushroom to a hyperlipidemic diet efficiently prevents the accumulation of LDL cholesterol and triacylglyceride in both the blood and liver of rats with hyperlipidemia (Bobek et al, 1998) and also reduces cholesterol biosynthesis by suppressing the activity of hepatic HMG-CoA reductase (Bobek et al, 1995) and accelerated cholesterol catabolism by up-regulating hepatic cholesterol 7β-hydroxylase (Bobek et al, 1994). It has been suggested that the fruiting bodies of oyster mushrooms could be recommended for consumption as a natural cholesterol-lowering agent in the human diet (Cimerman, 1999).…”

Section: Mushrooms As Hypocholesterolemic Agentsmentioning

confidence: 66%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

121

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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Section: Mushrooms As Hypocholesterolemic Agentsmentioning

confidence: 66%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

121

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“…A substantial reduction of total cholesterol in serum by PM-F2-OB could be attributed to a reduction in the activities of the liver enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is a rate-limiting enzyme in cholesterol biosynthesis. 42) Also, a substantial reduction in Fig, 3. Protective Effect of PM-F2-OM on Liver…”

Section: Discussionmentioning

confidence: 94%

Anti-obesity Effect of PM-F2-OB, an Anti-obesity Herbal Formulation, on Rats Fed a High-Fat Diet

Kang

Lee

et al. 2004

Biological & Pharmaceutical Bulletin

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PM-F2-OB is one of the most well-known traditional herbal medicines that are frequently used for the treatment of obesity in Korea. The anti-obesity effect of PM-F2-OB on rats fed a high-fat diet was investigated through analyses of changes in body weight, kidney fat weight, and blood biochemicals including cholesterol, free fatty acid, BUN, creatinine, HDL, LDL, phospholipids, SGOT, SGPT, total lipids, and triglycerides. The subjects in this study were divided into four groups: a normal group with a standard diet (N); a PM-F2-OB treatment group fed a standard diet (N؉PM-F2-OB); a control group fed a high-fat diet (C); and a PM-F2-OB treatment group fed a high-fat diet (C؉PM-F2-OB). There were no significant differences in body weight change between the N and N؉PM-F2-OB treatments. Also, there was no significant difference in the amount of food intake between the C and C؉PM-F2-OB treatments. These results suggest that PM-F2-OB has no significant toxicity and does not induce a dislike for that diet due to its smell or taste. Rats were administered a high-fat diet (20% (w/w)) for six weeks to induce obesity. The study shows that PM-F2-OB significantly prevented increases in body weight, cholesterol, LDL and total lipids that resulted from the high-fat diet. PM-F2-OB also decreased kidney fat weight and free fatty acid, phospholipid, and triglyceride concentrations induced by the high-fat diet to level equals or below the normal diet group. It was concluded from the results that PM-F2-OB has a distinct anti-obesity effect.

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“…This could be due to a reduction in the activity of the liver enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. 15) Therefore it is suggested that the hypocholesterolemic effect of HW extract from cultured mycelia of C. sinensis might be mediated by several mechanisms. A substantial reduction in LDL cholesterol and TC levels in serum could also be achieved by reduced production of TC by liver tissue and/or efficient removal of the LDL cholesterol by various tissues without subsequent renewal.…”

Section: Mycelial Growth In the Jar Fermentermentioning

confidence: 99%

Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensis.

Koh¹,

Kim

Chang

et al. 2003

Biological & Pharmaceutical Bulletin

101

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It has been discovered that the medicinal properties of cultured mycelia are equally effectively as those of Cordyceps sp. found in the wild.1) Studies suggest that Cordyceps sinensis, which forms a fruiting body on the larvae of moths, may promote natural vitality and have diverse bioactivities.2,3) In addition, Cordyceps militaris, a species that is a parasite fungus on the larvae of Lepidoptera, has received considerable attention as a potential anti-hyperlipidemia agent. 4)However, since these physiologically active substances contained in various Cordyceps sp. were extracted from natural or the solid cultured stromata, only a few active substances from them have been developed for commercial use. Therefore, to provide opportunities for increased economic efficiency and practical use, artificial media for high-volume production have recently been developed in Korea. found that the hot-water fraction (HW) from submerged cultured mycelia of C. sinensis stimulates bone marrow cell proliferation through Peyer's patch cells, activates macrophages, and has some bioactivities in vitro. 5)Recently, hyperlipidemia has received research attention. It is well documented that lowering circulating cholesterol, especially low-density lipoprotein (LDL) cholesterol, levels can prevent, arrest, and even reverse coronary atherosclerosis.6) Various edible mushrooms have already proven to be an important natural regimen for controlling hyperlipidemia due to their high content of fiber, proteins, and microelements and low fat content. 7,8) Although the hypolipidemic effect of mushrooms has been studied, no information is so far available on the hypocholesterolemic effect of the fungus C. sinensis. Therefore, the present paper investigated the potential cholesterol-lowering effect of the HW extract from mycelia of C. sinensis in mice. MATERIALS AND METHODSMicroorganism and Materials C. sinensis, which was a gift from Sanming Microbiological Institute in China, were used in this experiment. The medium used for liquid culture contained, per liter, the following: 100 g of molasses, 1 g of yeast extract, and 3 g of K 2 HPO 4 . The submerged cultivation of C. sinensis was carried out at 150 rpm, 25°C, pH 5, and airflow rate of 1.0 vvm for 7 d in a 5 l jar fermenter using the liquid culture medium. The enzymatic kits for total cholesterol (TC), triacylglycerol (TG), and high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) cholesterol were purchased from Sigma Chemical Co. (St. Louis, MO, U.S.A.).Animals Male ICR mice (6-8 weeks old) were obtained from Daihan-Biolink Co. (Korea). After an adaptation period, the mice were allowed free access to standard laboratory cholesterol-free and -enriched diets. Water was given ad libitum during the experimental period. They were housed under temperature (about 21°C) and humidity (about 60%)-controlled conventional clean conditions. Preparation of HW Extraction Samples were prepared to investigate the physiological effects of the HW extract from cultured mycelia of C. sinensis in...

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Oyster mushroom (Pleurotus ostreatus) reduces the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat liver microsomes

Cited by 32 publications

References 21 publications

Mushrooms as therapeutic agents

Mushrooms as therapeutic agents

Anti-obesity Effect of PM-F2-OB, an Anti-obesity Herbal Formulation, on Rats Fed a High-Fat Diet

Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensis.

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