Oxytocin – The Sweet Hormone?

Leng, Gareth; Sabatier, Nancy

doi:10.1016/j.tem.2017.02.007

Cited by 78 publications

(86 citation statements)

References 99 publications

(105 reference statements)

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“…The well-known functions of OT/VP are related to reproductive and social behavior, but accumulating evidence suggests it links its role in reproduction to energy status and feeding behavior in vertebrates (8). This is not surprising because reproduction depends on the availability of food and the energy balance of the organism.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

et al. 2018

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Ants are emerging model systems to study cellular signaling because distinct castes possess different physiologic phenotypes within the same colony. Here we studied the functionality of inotocin signaling, an insect ortholog of mammalian oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined that specialization within the colony, seasonal factors, and physiologic conditions down-regulated the expression of the OT-like signaling system. Given this natural variation, we interrogated its function using RNAi knockdowns. Next-generation RNA sequencing of OT-like precursor knock-down ants highlighted its role in the regulation of genes involved in metabolism. Knock-down ants exhibited higher walking activity and increased self-grooming in the brood chamber. We propose that OT-like signaling in ants is important for regulating metabolic processes and locomotion.-Liutkevičiūtė, Z., Gil-Mansilla, E., Eder, T., Casillas-Pérez, B., Di Giglio, M. G., Muratspahić, E., Grebien, F., Rattei, T., Muttenthaler, M., Cremer, S., Gruber, C. W. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.

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Section: Discussionmentioning

confidence: 99%

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

et al. 2018

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“…Oxytocin neurones of rat hypothalamic explants have been reported to be activated in response to glucose and insulin. 26,146 Oestrogen treatment has also been reported to increase oxytocin mRNA and induce anorexia in rats. 143 Peripheral or central administration of glucagon-like peptide 1 has been reported in rats to activate supraoptic nucleus neurones 144 or hypothalamic paraventricular oxytocin neurones.…”

Section: Activation Of Oxytocin Neurones By Food Intakementioning

confidence: 99%

“…130,146,159,160 Oxytocin administration has been shown to reduce food intake in laboratory animals and humans. 130,146,159,160 Oxytocin administration has been shown to reduce food intake in laboratory animals and humans.…”

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

“…146,181 Oxytocin has been reported to increase glucose uptake from muscle and adipose tissue, hepatic gluconeogenesis, insulin secretion from the pancreas, and lipolysis, leading to improved insulin sensitivity and lipid homeostasis. 146,181 Oxytocin has been reported to increase glucose uptake from muscle and adipose tissue, hepatic gluconeogenesis, insulin secretion from the pancreas, and lipolysis, leading to improved insulin sensitivity and lipid homeostasis.…”

Section: Roles Of Oxytocin In the Control Of Food Intakementioning

confidence: 99%

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Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information‐processing cerebral cortex; the cognitive information‐processing prefrontal cortex; reward‐related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress‐related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis‐controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.

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“…The mechanism underlying these observations is not known, although rats compensate for SCM consumption by reducing their intake of standard diet, suggesting that the difference seen here are not a consequence of a change in body weight or an increase in total daily energy intake. The hypothalamic neurohormone oxytocin has an emerging role in appetite control, and may be involved specifically in an anorexigenic response to carbohydrate intake . Oxytocin may have a neuromodulatory role in the SuM, and we have previously shown that gavage of a high‐sugar food increases the electrical activity of oxytocin neurones in the rat supraoptic nucleus, which may lead to somatodendritic oxytocin release to target the SuM.…”

Section: Discussionmentioning

confidence: 92%

Neural connectivity between the hypothalamic supramammillary nucleus and appetite‐ and motivation‐related regions of the rat brain

Plaisier

Hume

Menzies

2020

J Neuroendocrinology

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The supramammillary nucleus (SuM) has an emerging role in appetite control. We have shown that the rat SuM is activated during hunger or food anticipation, or by ghrelin administration. In the present study, we characterised the connectivity between the SuM and key appetite‐ and motivation‐related nuclei in the rat. In adult wild‐type rats, or rats expressing Cre recombinase under the control of the tyrosine hydroxylase (TH) promoter (TH‐Cre rats), we used c‐Fos immunohistochemistry to visualise and correlate the activation of medial SuM (SuMM) with activation in the lateral hypothalamic area (LH), the dorsomedial hypothalamus (DMH) or the ventral tegmental area (VTA) after voluntary consumption of a high‐sugar, high‐fat food. To determine neuroanatomical connectivity, we used retrograde and anterograde tracing methods to specifically investigate the neuronal inputs and outputs of the SuMM. After consumption of the food there were positive correlations between c‐Fos expression in the SuMM and the LH, DMH and VTA (P = 0.0001, 0.01 and 0.004). Using Fluoro‐Ruby as a retrograde tracer, we demonstrate the existence of inputs from the LH, DMH, VTA and ventromedial hypothalamus (VMH) to the SuMM. The SuMM showed reciprocal inputs to the LH and DMH, and we identified a TH‐positive output from SuMM to DMH. We co‐labelled retrogradely‐labelled sections for TH in the VMH, or for TH, orexin and melanin‐concentrating hormone in the LH and DMH. However, we did not observe any colocalisation of immunoreactivity with any retrogradely‐labelled cells. Viral mapping in TH‐Cre rats confirms the existence of a reciprocal SuMM‐DMH connection and shows that TH‐positive cells project from the SuMM and VTA to the lateral septal area and cingulate cortex, respectively. These data provide evidence for the connectivity of the SuMM to brain regions involved in appetite control, and form the foundation for functional and behavioural studies aiming to further characterise the brain circuitry controlling eating behaviours.

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Oxytocin – The Sweet Hormone?

Cited by 78 publications

References 99 publications

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Role of oxytocin in the control of stress and food intake

Neural connectivity between the hypothalamic supramammillary nucleus and appetite‐ and motivation‐related regions of the rat brain

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