Oxytocin: Structure, synthesis, receptors, and basic effects

Григорьева, М.Е.; Golubeva, M. G.

doi:10.1134/s1819712410020017

Cited by 3 publications

(3 citation statements)

References 59 publications

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“…CD38 -/mice do not show deficits in olfactory-guided foraging or habituation to non-social stimuli, indicating that genetic knockout of this gene does not impair olfactory function per se [100]. CD38 is implicated in the release of the neuropeptide oxytocin (OT; ( Table 1) from hypothalamic neurons [100,102]. OT is involved in sexual, affiliative and parental care behaviors [102,103], and can stimulate the release of prolactin, in concert with arginine vasopressin (AVP [104,105].…”

Section: Cd38mentioning

confidence: 99%

“…CD38 is implicated in the release of the neuropeptide oxytocin (OT; ( Table 1) from hypothalamic neurons [100,102]. OT is involved in sexual, affiliative and parental care behaviors [102,103], and can stimulate the release of prolactin, in concert with arginine vasopressin (AVP [104,105]. Neurons in the MPOA can activate dopaminergic neurons in the VTA, which innervate GABA neurons in the nucleus accumbens (NAcc; ( Table 1).…”

Section: Cd38mentioning

confidence: 99%

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The Role of Olfactory Genes in the Expression of Rodent Paternal Care Behavior

Rymer

2020

Genes

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Olfaction is the dominant sensory modality in rodents, and is crucial for regulating social behaviors, including parental care. Paternal care is rare in rodents, but can have significant consequences for offspring fitness, suggesting a need to understand the factors that regulate its expression. Pup-related odor cues are critical for the onset and maintenance of paternal care. Here, I consider the role of olfaction in the expression of paternal care in rodents. The medial preoptic area shares neural projections with the olfactory and accessory olfactory bulbs, which are responsible for the interpretation of olfactory cues detected by the main olfactory and vomeronasal systems. The olfactory, trace amine, membrane-spanning 4-pass A, vomeronasal 1, vomeronasal 2 and formyl peptide receptors are all involved in olfactory detection. I highlight the roles that 10 olfactory genes play in the expression of direct paternal care behaviors, acknowledging that this list is not exhaustive. Many of these genes modulate parental aggression towards intruders, and facilitate the recognition and discrimination of pups in general. Much of our understanding comes from studies on non-naturally paternal laboratory rodents. Future studies should explore what role these genes play in the regulation and expression of paternal care in naturally biparental species.

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Section: Cd38mentioning

confidence: 99%

Section: Cd38mentioning

confidence: 99%

The Role of Olfactory Genes in the Expression of Rodent Paternal Care Behavior

Rymer

2020

Genes

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“…Oxytocin is biologically similar to vasopressin (also known as antidiuretic hormone), and they are often studied in parallel, as both hormones also share some functions. Originally thought of as a hormone with a role limited to the uterus and milk ejection - oxytocin means “quick birth” in Greek[ 2 ] - further research has expanded understanding of its function across sexes and organ systems. Furthermore, it has become clear that in addition to physical function, oxytocin also wields important impact on social behaviors, which include stress and trust, anxiety, social interaction and bonding, and parental care[ 3 ], and thereby on neuropsychiatric disorders linked to these social behaviors.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin and cancer: An emerging link

Lerman¹,

Harricharran²,

Ogunwobi³

2018

WJCO

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The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research suggests that oxytocin effects may depend on cell type, concentration of the hormone, its interactions with other hormones in the microenvironment, and the precise localization of its receptor on the cell membrane. Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.

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Oxytocin receptor agonists and their clinical application

Tsirkin¹,

Трухина²,

Трухин³

et al. 2018

Ross. vestn. akush.-ginekol.

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Окситоцин-пептид, состоящий из 9 аминокислотных остатков со следующей их последовательностью: цистеинтирозин-изолейцин-глутамин-аспарагин-цистеин-пролинлейцин-глицинамид. Между двумя цистеиновыми группами имеется дисульфидный мостик, что делает эту молекулу циклической. Она состоит из кольца, образованного первыми шестью аминокислотными остатками, и «хвоста», пред-ставленного пролином, лейцином и глицинамидом [1-5]. Общеизвестно [1, 3, 6], что окситоцин широко используется в акушерской практике для индукции родовой деятельности, родостимуляции, остановки атонических послеродовых кровотечений, а также для усиления лактации. Так как препарат свободен от белков, его можно вводить внутривенно без опасности анафилактического и пирогенного

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Oxytocin: Structure, synthesis, receptors, and basic effects

Cited by 3 publications

References 59 publications

The Role of Olfactory Genes in the Expression of Rodent Paternal Care Behavior

The Role of Olfactory Genes in the Expression of Rodent Paternal Care Behavior

Oxytocin and cancer: An emerging link

Oxytocin receptor agonists and their clinical application

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