Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Maldonado, Paloma P.; Nuno-Perez, Alvaro; Kirchner, Jan H.; Hammock, Elizabeth A. D.; Gjorgjieva, Julijana; Löhmann, Christian

doi:10.1016/j.cub.2020.10.028

Cited by 23 publications

(26 citation statements)

References 73 publications

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“…In cortical L2/3, SST interneuron synapses onto pyramidal cells emerge at the beginning of the second post-natal week (Guan et al, 2017), when oxytocin release also increases SST interneuron excitability and sparsifies neuronal activity (Maldonado et al, 2021). At this age, SST interneuron-mediated inhibition is strong and can be readily recorded in the somas of cortical pyramidal neurons.…”

Section: Discussionmentioning

confidence: 99%

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Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex

et al. 2021

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Section: Discussionmentioning

confidence: 99%

“…Image processing Two-photon As described previously (Maldonado et al, 2021), two-photon image processing drift and movement artifacts were removed from each recording using NoRMCorre (Pnevmatikakis and Giovannucci, 2017). Delta F stacks were made using the mean fluorescence per pixel as baseline.…”

Section: Quantification and Statistical Analysismentioning

confidence: 99%

Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex

et al. 2021

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“…This result may reflect actual changes in the number of SST+-neurons, or alternatively changes in SST expression and hence more reliable detection of SST-synthesizing neurons. Interestingly, OT modulates the activity of the SST+-neurons, increasing the excitability of SST interneurons (63) but no studies report an effect of OT on SST production.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism

Bertoni

Schaller

Tyzio

et al. 2020

Preprint

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Several studies on rodent models with an Autism Spectrum Disorders-like (ASD) phenotype, notably Magel2-deficient mice, have shown a rescue of deficits in adult social behavior after neonatal administration of oxytocin. However, the neurobiological alterations responsible for the social deficits and the mechanism by which oxytocin-administration in infancy has a rescue effect in adulthood remain unclear.Here we show that Magel2-deficient adult mice exhibit a deficit in social memory that is corrected by neonatal oxytocin administration. We studied hippocampal regions known to be associated with social memory engrams involving the OT-system. At critical stages of development, we characterized cellular, physiological and biochemical alterations of these hippocampal regions in Magel2-deficient mice, alterations present in several ASD models. Overall we demonstrate a strong impact of oxytocin-administration at key stages of postnatal hippocampal neurodevelopment, shedding light on the role for oxytocin in treating neurodevelopmental disorders characterized by deficits in social memory.

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“…We focused in S1 L2/3 pyramidal neurons for this study. Recent work showed that oxytocin affects spontaneous network events differentially in S1 and V1 (Maldonado et al, 2021 ). Given the complexity of the effects of oxytocin, studies on more cell types, more brain regions, and at more developmental stages, as well as more in-depth investigations of OXTR downstream signaling under these different conditions, are needed for a full understanding of its function.…”

Section: Discussionmentioning

confidence: 99%

“…Since we observed an increase in GABAergic input to L2/3 pyramidal neurons at P28, the increased OXTR expression likely enhanced the synaptic output of GABAergic neurons onto pyramidal neurons. A recent study indeed showed that oxytocin can enhance the excitability of SST neurons, thereby reducing the level of spontaneous activity (Maldonado et al, 2021).…”

Section: Effects Of Oxytocin On Synaptic Transmission At P28mentioning

confidence: 99%

Oxytocin Regulates Synaptic Transmission in the Sensory Cortices in a Developmentally Dynamic Manner

Zhang

Miao

et al. 2021

Front. Cell. Neurosci.

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The development and stabilization of neuronal circuits are critical to proper brain function. Synapses are the building blocks of neural circuits. Here we examine the effects of the neuropeptide oxytocin on synaptic transmission in L2/3 pyramidal neurons of the barrel field of the primary somatosensory cortex (S1BF). We find that perfusion of oxytocin onto acute brain slices significantly increases the frequency of miniature excitatory postsynaptic currents (mEPSC) of S1BF L2/3 pyramidal neurons at P10 and P14, but reduces it at the later ages of P22 and P28; the transition occurs at around P18. Since oxytocin expression is itself regulated by sensory experience, we also examine whether the effects of oxytocin on excitatory synaptic transmission correlate with that of sensory experience. We find that, indeed, the effects of sensory experience and oxytocin on excitatory synaptic transmission of L2/3 pyramidal neurons both peak at around P14 and plateau around P18, suggesting that they regulate a specific form of synaptic plasticity in L2/3 pyramidal neurons, with a sensitive/critical period ending around P18. Consistently, oxytocin receptor (Oxtr) expression in glutamatergic neurons of the upper layers of the cerebral cortex peaks around P14. By P28, however, Oxtr expression becomes more prominent in GABAergic neurons, especially somatostatin (SST) neurons. At P28, oxytocin perfusion increases inhibitory synaptic transmission and reduces excitatory synaptic transmission, effects that result in a net reduction of neuronal excitation, in contrast to increased excitation at P14. Using oxytocin knockout mice and Oxtr conditional knockout mice, we show that loss-of-function of oxytocin affects baseline excitatory synaptic transmission, while Oxtr is required for oxytocin-induced changes in excitatory synaptic transmission, at both P14 and P28. Together, these results demonstrate that oxytocin has complex and dynamic functions in regulating synaptic transmission in cortical L2/3 pyramidal neurons. These findings add to existing knowledge of the function of oxytocin in regulating neural circuit development and plasticity.

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Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Cited by 23 publications

References 73 publications

Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex

Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex

Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism

Oxytocin Regulates Synaptic Transmission in the Sensory Cortices in a Developmentally Dynamic Manner

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