Oxytocin reproducing reflex milk ejection in lactating women.

Sala, Néstor L.; Luther, E C; Arballo, J C; Funes, J.Cordero

doi:10.1152/jappl.1974.36.2.154

Cited by 29 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to its best known roles in parturition and lactation (Sala et al, 1974;Arrowsmith and Wray, 2014), OT is involved in the regulation of a wide variety of physiological and pathological functions such as social memory and attachment, sexual and maternal behavior, and human bonding and trust (Lee et al, 2009). Some studies have also demonstrated that OT could modulate nociception and pain, and most work has focused on the CNS, especially on the spinal cord as the site of OT analgesia (Robinson et al, 2002;Condes-Lara et al, 2003;Yu et al, 2003;Yang et al, 2007Yang et al, , 2011bBreton et al, 2008;Russo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

View full text Add to dashboard Cite

“…The well-known physiological function of OT was to induce uterine contraction and milk ejection reflex [14,17]. In recent years, more and more studies indicated that OT might be involved in the regulation of gastrointestinal motility but the effect appeared to be species and region specific.…”

Section: Introductionmentioning

confidence: 99%

CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats

Feng

Che

et al. 2010

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

The aim of the present study was to investigate the effect of oxytocin (OT) on duodenum motility in rats and the possibility that cholecystokinin (CCK) was involved in this process. The isometric contraction of longitudinal muscle strips of duodenum was monitored by polygraph. ELISA was used to measure the concentration of CCK and OT in duodenum. CCK mRNA was assayed by RT-PCR. Oxytocin receptor (OTR) and CCK in duodenum were located by immunohistochemistry and immunofluorescence staining. OT (10⁻⁵ and 10⁻⁶ M) inhibited the spontaneous contraction of the muscle strips. On the contrary, atosiban (OT receptor antagonist), lorglumide (CCK₁ receptor antagonist), and tetrodotoxin (TTX, blocker of voltage-dependent Na(+) channel on nerve fiber) excited the contraction. The inhibitory effect of OT on duodenal motility was reversed by pretreatment of atosiban, lorglumide, or TTX. Exogenous OT did not influence the expression of OT mRNA in duodenum but increased the concentration of CCK in the culture medium of the cells isolated from longitudinal muscle myenteric plexus. The OTR and CCK were co-expressed in the neurons of the myenteric plexus in duodenum. We concluded that OT inhibited the contraction of the LD spontaneous contraction of rats in vitro. This effect was mediated by the CCK released from the neurons of the myenteric plexus in duodenum.

show abstract

“…Oxytocinergic signaling thus appears to play an important role in multiple GI functions that are subject to neuronal regulation. enteric nervous system; nurture; oxytocin receptor knockout; colitis OXYTOCIN (OT) is best known as a hormone produced in hypothalamo-hypophyseal neurons that stimulates OT receptors (OTR) to initiate milk letdown and parturition (16,17,39,47,57). OT/OTR, however, also participate in additional nurture-related central nervous system (CNS) processes that oppose stress, such as bonding and social interaction (6,16,21,26,56).…”

mentioning

confidence: 99%

Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice

Welch

Margolis

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

125

136

View full text Add to dashboard Cite

Enteric neurons express oxytocin (OT); moreover, enteric neurons and enterocytes express developmentally regulated OT receptors (OTRs). Although OT (with secretin) opposes intestinal inflammation, physiological roles played by enteric OT/OTR signaling have not previously been determined. We tested hypotheses that OT/OTR signaling contributes to enteric nervous system (ENS)-related gastrointestinal (GI) physiology. GI functions and OT effects were compared in OTR-knockout (OTRKO) and wild-type (WT) mice. Stool mass and water content were greater in OTRKO mice than in WT. GI transit time in OTRKO animals was faster than in WT; OT inhibited in vitro generation of ENS-dependent colonic migrating motor complexes in WT but not in OTRKO mice. Myenteric neurons were hyperplastic in OTRKO animals, and mucosal exposure to cholera toxin (CTX) in vitro activated Fos in more myenteric neurons in OTRKO than WT than in WT mice; OT inhibited the CTX response in WT but not in OTRKO mice. Villi and crypts were shorter in OTRKO than in WT mice, and transit-amplifying cell proliferation in OTRKO crypts was deficient. Macromolecular intestinal permeability in OTRKO was greater than WT mice, and experimental colitis was more severe in OTRKO mice; moreover, OT protected WT animals from colitis. Observations suggest that OT/OTR signaling acts as a brake on intestinal motility, decreases mucosal activation of enteric neurons, and promotes enteric neuronal development and/or survival. It also regulates proliferation of crypt cells and mucosal permeability; moreover OT/OTR signaling is protective against inflammation. Oxytocinergic signaling thus appears to play an important role in multiple GI functions that are subject to neuronal regulation.

show abstract

Oxytocin reproducing reflex milk ejection in lactating women.

Cited by 29 publications

References 0 publications

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats

Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice

Contact Info

Product

Resources

About