Oxytocin reduces caloric intake in men

Lawson, Elizabeth A.; Marengi, Dean A.; DeSanti, Rebecca; Holmes, Tara M.; Schoenfeld, David; Tolley, Christiane

doi:10.1002/oby.21069

Cited by 177 publications

(223 citation statements)

References 40 publications

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“…Oxytocin has also been linked to energy homeostasis mechanisms in animals, where it acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis [27][28][29][30][31]. Oxytocin has also been shown to play an important role in metabolism and energy balance in humans [32,33], such as reducing caloric intake with a preferential effect on fat intake [11] and reward-driven food intake in humans [34]. These findings are in line with our finding that reduced levels of delta oxytocin correlate with a high BMI in CP patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, in contrast to vasopressin, whose function is well understood and the clinical symptoms in vasopressin-deficient patients are well known [10], little is known about the role of oxytocin in CP patients. Oxytocin is involved in metabolism [11] and in the regulation of a wide variety of social and non-social behaviors such as nonsocial memory, anxiety, depression, and stress [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin in survivors of childhood-onset craniopharyngioma

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxytocin in survivors of childhood-onset craniopharyngioma

et al. 2016

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“…Knowing that oxytocin inhibits weight gain in rodent models [21,41], and that oxytocin modulates appetite in human subjects [29], plasma levels of oxytocin were tested in mice of long-and short-term experiments. We found significantly elevated blood plasma oxytocin levels in C57BL/6 mice getting canine-source L. reuteri 2546 in their water, when compared with age-matched controls drinking regular water ( Figures 5A and 5B).…”

Section: Canine Bacteria Induce Neuropeptide Hormone Oxytocinmentioning

confidence: 99%

“…Recognizing that oxytocin inhibits weight gain in rodent models [21,41] and in humans [29], we challenged oxytocin-deficient B6;129S-Oxttm1Wsy/J mutant mice with canine source L. reuteri 2546 to determine whether this neurotropic hormone oxytocin is essential for L. reuteri 2546-induced weight control. We found that mice globally lacking oxytocin did not benefit from microbe-induced body weight Figures 5C and 5D).…”

Section: Consumption Of L Reuteri Reduces Risk For Obesity In An Oxymentioning

confidence: 99%

“…Specifically, studies show oxytocin has roles in reducing food intake and body weight in dietinduced obesity [17,19,[21][22][23] in genetically obese rodent models [18,20,21], highlighting potential downstream CNS and peripheral mechanisms. It was also shown that intranasal administration of oxytocin in humans lowers caloric intake and has beneficial metabolic effects, resulting in a shift from carbohydrate to fat utilization and improved insulin sensitivity [29]. Recognizing that oxytocin is important in the mother-infant bond, it was earlier found that ingested L. reuteri ATCC 6475 bacteria extracted from human milk serve to upregulate systemic oxytocin levels in mouse models by a vagus nervedependent mechanism [30].…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Dog Bacteria Up-Regulate Oxytocin and Lower Risk of Obesity

Varian¹,

Levkovich²,

Poutahidis³

et al. 2017

J Prob Health

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AnimalsC57BL/6 wild type (wt), oxytocin-wt (oxt-wt) and oxytocin- AbstractCohabitation with pet dogs imparts diverse health benefits to humans including a slim physique. It is known that neuropeptide hormone oxytocin fundamental in human-canine social bonds regulates appetite and body weight. It was recently shown in mice that consuming Lactobacillus reuteri ATCC 6475 from human breast milk lowers body weight and up-regulates oxytocin levels in blood. Here we test the hypothesis that bacteria from dog saliva may similarly modulate recipient host body weight. We find that a Lactobacillus spp isolate from dog saliva led to lower body weight when fed to C57BL/6 wild type mice. Mice consuming the canineborne L. reuteri also had elevated oxytocin levels in blood plasma, and exhibited body weight in an oxytocin-dependent manner. Interestingly, killed (lysed) canine bacteria were sufficient to achieve the physiological effects. Taken together, these studies provide evidence that dog bacteria modulate oxytocin levels and body weight in recipient mice, and thus may help reduce risk of obesity in individuals cohabitating with pet dogs. knockout (oxt-ko) B6; 129S-Oxttm1Wsy/J mice (purchased initially from Jackson labs; Bar Harbor, ME) were used in three separate experiments (Figure 1). Mice were housed and handled in Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)-accredited facilities using techniques and diets including Lactobacillus reuteri as specifically approved by Massachusetts Institute of Technology's (MIT) Committee on Animal Care (CAC). Mice were housed under standard 12:12 light cycle conditions with lights on at 7 AM. Mice were fed a standard control chow Purina RMH3000. Beneficial Dog Bacteria Up-Regulate Oxytocin and Lower Risk of ObesityMice were bred in-house to achieve experimental groups. Each experiment included 5-15 animals per group with one or two replications (total N=10-30 mice examined per group) unless otherwise specified. For the initial studies, C57BL/6 wt mice received Lactobacillus reuteri 2546 isolated from dog saliva. To test putative roles for microbeinduced oxytocin in obesity, oxt-ko mice and their oxt-wt littermates entered experiments at eight weeks of age. At the conclusion of the study mice were euthanized with CO 2 overdose, and were examined as described below. Eight pet dogs served as saliva microbe donors as approved by the MIT-CAC. Saliva was collected from these dogs in the morning before feeding using sterile swabs [Puritan Sterile Polyester Tipped applicators Guilford, Me Ref: 25-806 1PD] in 1.5 ml centrifuge tubes (Safeseal Microcentrifuge Tubes, Sorenson Bioscience Inc. Salt Lace City, UT Cat# 16070). Bacteria were purified from dog saliva as described in detail below. PCR of dog saliva for all Lactobacillus speciesSaliva was collected from eight pet dogs and prepared using High Pure PCR Template kit (Roche Diagnostics) was used without changes to the manufacturer's directions to isolate DNA from the canine saliva. DNA was measured using Nan...

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