Oxytocin Receptors: Triggers for Parturition and Lactation?

Soloff, Melvyn S.; Alexandrová, M; Fernström, Martha J.

doi:10.1126/science.221972

Cited by 394 publications

(195 citation statements)

References 32 publications

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“…The oestrogen to progesterone ratio increases in the plasma of the rat during late pregnancy (Soloff et al 1979). This increase is due to an increase in the concentration of oestrogen (Y oshinaga et al 1969;Shaikh 1971) and to a decrease in the concentration of progesterone (Soloff et al 1979).…”

Section: Discussionmentioning

confidence: 99%

“…This increase is due to an increase in the concentration of oestrogen (Y oshinaga et al 1969;Shaikh 1971) and to a decrease in the concentration of progesterone (Soloff et al 1979). Administration of oestrogen to rats after the removal of the ovaries increases prolactin secretion Lawson and Gala 1974;Vermouth and Deis 1974), while the administration of progesterone immediately after ovariectomy prevents this increase (Vermouth and Deis 1974).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Nicholas¹,

Hartmann²

1981

Aust. Jnl. Of Bio. Sci.

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The relationship between progesterone, prolactin, corticosteroids and corticosteroid binding globulin . (CBO) activity in plasma and the initiation of lactation were studied in normal parturient rats, and rats either ovariohysterectomized or Caesarean-sectioned on day 19 of gestation. In chronically cannulated rats the decline in plasma progesterone to low values « 10 p.g/l) in normal parturient rats 20 h before term and in Caesarean-sectioned rats 10--14 h after surgery was closely related to an increase in plasma prolactin. However, in ovariohysterectomized rats the levels of progesterone declined abruptly to 20 p.g/l within 30 min of surgery and prolactin remained low (5 p.g/l) for 4-8 h and then gradually increased during the subsequent 16-18 h. Lactose concentrations in mammary tissue of rats killed at 0, 12, 18. 24, 36 and 48 h after surgery was low « 0·14 mg/g tissue) up to 12 h, and increased to reach maximum values at 36 hand 48 h after surgery in ovariohysterectomized and Caesarean-sectioned rats respectively.The concentration of corticosteroids and CBO capacity in the plasma was 250--550 p.g/l and 250-480 p.g corticosterone bound per litre, respectively, in rats killed during the last 4 days of,gestation. However, both the concentration of corticosteroids and the CBO capacity, within the individual cannulated rats, remained relatively constant during late gestation.These findings support the proposal that progesterone withdrawal is the lactogenic trigger ana suggest the sequential involvement of prolactin. An increase in the concentration of free corticosteroids in late pregnancy and a related stimulatory role in the lactogenic mechanism were not established.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Nicholas¹,

Hartmann²

1981

Aust. Jnl. Of Bio. Sci.

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“…From our results, the increase of cortisol and the decrease of progesterone appeared to be involved in the onset of labor. Soloff et al (1979) reported that oxytocin receptors in the rat myometrium increased to the maximam at or near the labor. Investigations on the relationship between quantity of oxytocin receptors and hormonal changes should be necessary.…”

Section: Discussionmentioning

confidence: 99%

Hormonal changes around the parturition in rats.

Yoshida

Suzuki

Hattori

et al. 1981

Tohoku J. Exp. Med.

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“…The human OXTR gene is located on chromosome locus 3p25. The expression levels of oxytocin receptors in the myoepithelial cells surrounding the alveoli of mammary glands remain constantly elevated throughout the lactation period (Soloff et al 1979).…”

Section: Introductionmentioning

confidence: 99%

An overview of the oxytocin-oxytocin receptor signaling network

Chatterjee

Patil

Sahu

et al. 2016

J. Cell Commun. Signal.

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Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically curated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events.

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Oxytocin Receptors: Triggers for Parturition and Lactation?

Cited by 394 publications

References 32 publications

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Progressive Changes in Plasma Progesterone, Prolactin and Corticosteroid Levels During Late Pregnancy and the Initiation of Lactose Synthesis in the Rat

Hormonal changes around the parturition in rats.

An overview of the oxytocin-oxytocin receptor signaling network

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