Oxytocin protects cardiomyocytes from apoptosis induced by ischemia–reperfusion in rat heart: Role of mitochondrial ATP-dependent potassium channel and permeability transition pore

Alizadeh, Ali Mohammad; Faghihi, Mahdieh; Khori, Vahid; Sohanaki, Hamid; Pourkhalili, Khalil; Mohammadghasemi, Fahimeh; Mohsenikia, Maryam

doi:10.1016/j.peptides.2012.03.023

Cited by 50 publications

(34 citation statements)

References 17 publications

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“…The effects of oxytocin on I/R have been reported in limited number of studies. [51,52] Oxytocin reduces I/R injury in rat kidney, with improved renal function, as indicated by decreased serum creatinine and BUN levels in addition to improved antioxidant status and reduced ROS. [53] Moreover, the protective effect of oxytocin on I/R injury in the liver, kidney, stomach, and urinary bladder have been reported.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Fırat¹,

Erdemır²,

Kölükçü³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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Section: Discussionmentioning

confidence: 99%

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Fırat¹,

Erdemır²,

Kölükçü³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…One study revealed that oxytocin is protective against myocardial ischemia-reperfusion injury by reducing the area of myocardial infarction and myocardial enzyme release, and this effect was inhibited by 5-HD and atractyloside (a mPTP-opening agent). ROS produced in the process of anoxia-reoxygenation regulate the permeability of the mPTP and thus reduce apoptosis, while mitoKATP regulates the production of ROS (25). The mitoKATP channel has a protective role in anoxia-reoxygenation injury; however, the precise location of interference with the process remains to be identified.…”

Section: B Amentioning

confidence: 99%

Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel

Yin

et al. 2014

Molecular Medicine Reports

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“…Cardiotoxic agents causes alterations in this pattern, including disorganization of myofibrils and mitochondria, vacuolization of the cytoplasm, and degeneration of crista inside the mitochondria [56] that we could observe on the Figure 2 We can note that previous studies cited in this work did not use any image technique to obtain low-Z elemental and structural information about the health tissue although, it is important to know how some elements are distributed to study any problem on the cardiac tissue. Indeed LEXRF technique is also able to identify and locate the elements taking into account a semi-quantitative analysis and colocalization.…”

Section: Discussionmentioning

confidence: 71%

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction; Magnesium, because it is important in the cardiac metabolism; and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase How to cite this paper: Mantuano, A., Barroso, R.C., Nogueira, L.P., Colaço, M.V., Mota, C.L., Pickler, A., Braz, D., Salata, C., Ferreira-Machado, S., de Almeida, C.E. and 755contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Facility, at the beamline TwinMic, in Trieste, Italy.

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Oxytocin protects cardiomyocytes from apoptosis induced by ischemia–reperfusion in rat heart: Role of mitochondrial ATP-dependent potassium channel and permeability transition pore

Cited by 50 publications

References 17 publications

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

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