Oxytocin or Social Housing Alleviates Local Burn Injury in Rats

İşeri, Sevgin Özlem; Düşünceli, Fikret; Erzik, Can; Uslu, Bahar; Arbak, Serap; Yeğen, Berrak Ç.

doi:10.1016/j.jss.2009.02.018

Cited by 30 publications

(19 citation statements)

References 53 publications

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“…It acts as a scavenger of toxic free radicals such as hydroxyl radicals and peroxynitrite reduces buminduced oxidative damage in liver as well as in other tissues (gut, kidney and gastric mucosa) (15)(16)(17). TNF-a is one of the first-wave cytokines secreted by macrophages in response to thermal injury resulting in the multiple organ damage, including liver (19)(20). High hepatic TNF-a level is elevated at the 24 th hour after burns thus indicating the role of this cytokine in bum-induced local and systemic inflammation.…”

Section: Nf-lcbmentioning

confidence: 99%

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Bekyarova

Apostolova

Kotzev

2012

Int J Immunopathol Pharmacol

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Melatonin exhibits a wide variety of biological activity including antioxidant and anti-inflammatory effects. We have previously reported its protective effect on hepatic oxidative hepatic injury in burns. In this study, we investigated the role of nuclear factor kappa B (NF-kB) in melatonin-mediated protection against liver injury by using the burned-rat model. Melatonin (N-acetyl-5-methoxytriptamin, 10mgl kg (-1), Lp.) was administered immediately and 12 hours after thermal skin injury. Hepatic NF-kB expression was determined by Western blotting. TNF-a level in liver homogenate was quantified using enzyme-linked immunosorbent assay (ELISA) kit. Plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver injury at the 24 th hour after burns. Thermal skin injury caused significant elevation of hepatic NF-kB expression by 48%, TNF-a level by 55% and plasma AST and ALT activities by 2-and 3-fold, respectively, in comparison with normal control rats. Treatment with melatonin decreased significantly elevated hepatic NF-kB activity and TNF-a, maintaining the levels close to the control values Melatonin suppressed the elevation of plasma AST and ALT activities (p

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Section: Nf-lcbmentioning

confidence: 99%

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Bekyarova

Apostolova

Kotzev

2012

Int J Immunopathol Pharmacol

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“…In a previous study, being in a social environment has been shown to increase oxytocin level [29]. It has been observed that wound healing is delayed with social isolation and that healing is also delayed in burn-induced ileal stress injury in the event of social isolation [29].…”

Section: Participationmentioning

confidence: 95%

“…It has been observed that wound healing is delayed with social isolation and that healing is also delayed in burn-induced ileal stress injury in the event of social isolation [29]. Social cognitive skills such as empathy, emotional perception, and developing a reasonable perspective are impaired in schizophrenic patients and this condition has been found to arise from a dysfunction in the oxytocinergic system and likely to be improved with oxytocin therapy [30].…”

Section: Participationmentioning

confidence: 99%

Methodological Approach in Perception Management

Cabıoğlu¹,

İşeri²

2015

OALib

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Perception is the interpretation of the sensory stimuli received from the environment. Visual, auditory, and tactile senses are collected and interpreted in the "General Interpretation Area" (Wernicke's area). This area alone plays a much more active role than all other regions of the cortex in the comprehension of the brain called intelligence. We comprehend the events as a whole with the combination of the visual, auditory, and tactile perceptions in the Wernicke's area; the events remain longer in our memory and its impact on us is stronger. This situation is called multi-sensory perception. Different pressure groups are in an effort to influence the feelings, sensations, systems of thought, and actions of their target population in order to ensure their target population to behave in line with their targets. In this respect, "Perception Management" is defined as all activities that are performed to influence the thoughts of a target population. Modeling, focusing attention on a specific point, creating an expectation, participation, rewarding, punishment, and stress management are among the methods applied in perception management. If we learn these methodological approaches used in perception management, we are in the opinion that it would be easy for individuals to decide independently by preventing them from the influence and manipulation of different pressure groups on their decision-making processes. Today, pressure groups aim at managing the community in line with their targets by influencing single individuals mostly using the perception management method.

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“…Liver plays a pivotal role in a thermal injury by modulating the immune function, inflammatory processes, and the acute-phase response. TNF-α is one of the first-wave cytokines secreted by macrophages in response to an injurious stimulus which results in the multiple organ damage following burns [33][34][35][36]. TNF-α elicits synthesis and release of a cascade of cytokine mediators such as IL-1, IL-6, IL-8, and platelet activating factor (PAF).…”

Section: Early Inflammatory Response Post-burn Liver Injury and Apopmentioning

confidence: 99%

Melatonin protection against burn-induced liver injury. A review

et al. 2014

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AbstractSevere thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.

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Oxytocin or Social Housing Alleviates Local Burn Injury in Rats

Cited by 30 publications

References 53 publications

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Methodological Approach in Perception Management

Melatonin protection against burn-induced liver injury. A review

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