Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

Lukas, Michael; Toth, Iulia; Veenema, Alexa H.; Neumann, Inga D.

doi:10.1016/j.psyneuen.2012.09.018

Cited by 183 publications

(155 citation statements)

References 40 publications

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“…This is in line with a previous study in a rodent model of social deficit in schizophrenia showing that, although hypothalamic OT mRNA levels were significantly decreased, OTR binding was increased in the central nucleus of the amygdala (Lee et al, 2005). The fact that both the septum and amygdala have been implicated in the stress-regulating and social-enhancing properties of OT (Domes et al, 2007;Lukas et al 2013) is further suggestive of the OT-ergic system involvement in the negative emotional consequences of opioid withdrawal.…”

Section: Discussionsupporting

confidence: 91%

The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

Zanos

Georgiou

Wright

et al. 2013

Neuropsychopharmacol

118

110

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The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse. Emerging evidence suggests a role of the neurohypophysial peptide oxytocin (OT) in the modulation of mood disorders as well as drug addiction. However, its involvement in the emotional consequences of drug abstinence remains unclear. We investigated the effect of 7-day opioid abstinence on the oxytocinergic system and assessed the effect of the OT analogue carbetocin (CBT) on the emotional consequences of opioid abstinence, as well as relapse. Male C57BL/6J mice were treated with a chronic escalating-dose morphine regimen (20-100 mg/kg/day, i.p.). Seven days withdrawal from this administration paradigm induced a decrease of hypothalamic OT levels and a concomitant increase of oxytocin receptor (OTR) binding in the lateral septum and amygdala. Although no physical withdrawal symptoms or alterations in the plasma corticosterone levels were observed after 7 days of abstinence, mice exhibited increased anxiety-like and depressive-like behaviors and impaired sociability. CBT (6.4 mg/kg, i.p.) attenuated the observed negative emotional consequences of opioid withdrawal. Furthermore, in the conditioned place preference paradigm with 10 mg/kg morphine conditioning, CBT (6.4 mg/kg, i.p.) was able to prevent the stress-induced reinstatement to morphine-seeking following extinction. Overall, our results suggest that alterations of the oxytocinergic system contribute to the mechanisms underlying anxiety, depression, and social deficits observed during opioid abstinence. This study also highlights the oxytocinergic system as a target for developing pharmacotherapy for the treatment of emotional impairment associated with abstinence and thereby prevention of relapse.

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Section: Discussionsupporting

confidence: 91%

The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

Zanos

Georgiou

Wright

et al. 2013

Neuropsychopharmacol

118

110

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“…Long-term subordination was also induced in rats without former exposure to stress by microinfusion of an oxytocin receptor antagonist in the medial amygdala immediately after hierarchy formation 156 , which suggests a role for the modulation of oxytocin receptors in stress-induced facilitation of long-term subordination. This view is in agreement with the findings of pharmacological experiments that implicated oxytocin in the medial amygdala in the establishment of social memories in rats 158 . Prenatal stress in rats both diminished the quality of social interactions at adulthood and resulted in alterations in the oxytocin system in the hypothalamus and amygdala: administration of oxytocin in these animals at adulthood reversed the social deficits 159 .…”

Section: Oxytocin and Vasopressinsupporting

confidence: 91%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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“…Considering that the septum is a brain region hypothesized to be responsible for the anxiolytic effects of OT (Lukas et al, 2013), it is likely that the dysregulation of the OTR system in the LS to be a possible mechanism underlying the anxiety-related symptoms observed in the present study. In fact, we have previously shown that decreased OT content in the brain was concomitant with an increase in the OTR in the lateral septum (Zanos et al, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 88%

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

et al. 2016

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Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype, Neuropharmacology (2016), doi: 10.1016/ j.neuropharm.2016.02.012. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics

Cited by 183 publications

References 40 publications

The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice

Stress and the social brain: behavioural effects and neurobiological mechanisms

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

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