Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine

Kuwabara, Yoshinori; Takeda, Satoru; Mizuno, Masahiko; Sakamoto, Shoichi

doi:10.1007/bf00931436

Cited by 60 publications

(49 citation statements)

References 15 publications

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“…Researchers studying 76 full-term infants found that plasma OT levels were lower at 4 days of life than at 0.5 hr of life, though the result was not statistically significant (Leake, Weitzman, & Fisher, 1981). Others found significantly lower plasma OT levels in term infants at 7 versus 2 days of life (Kuwabara et al, 1987). Future research is needed to find physiologic explanations for the maturational decrease in plasma OT levels.…”

Section: Discussionmentioning

confidence: 99%

“…OT is present in human fetal brain tissues as early as 14 weeks gestation, and its levels significantly increase throughout the course of gestation in areas of the brain such as the pituitary and the hypothalamus (Burford & Robinson, 1982). Investigators have not measured OT longitudinally in fetal umbilical plasma, but cross-sectional measurements have been successful in fetuses near the time of labor (Kuwabara, Takeda, Mizuno, & Sakamoto, 1987). In healthy, term human infants, OT is measurable in plasma (Kuwabara et al, 1987), urine (White-Traut, Powlesland, Gelhar, Chatterton, & Morris, 1998), saliva (Feldman, Gordon, & Zagoory-Sharon, 2010), and cerebral spinal fluid (CSF; Clark et al, 2013).…”

mentioning

confidence: 99%

“…Investigators have not measured OT longitudinally in fetal umbilical plasma, but cross-sectional measurements have been successful in fetuses near the time of labor (Kuwabara, Takeda, Mizuno, & Sakamoto, 1987). In healthy, term human infants, OT is measurable in plasma (Kuwabara et al, 1987), urine (White-Traut, Powlesland, Gelhar, Chatterton, & Morris, 1998), saliva (Feldman, Gordon, & Zagoory-Sharon, 2010), and cerebral spinal fluid (CSF; Clark et al, 2013). While the neuroprotective properties of OT suggest promising applications for vulnerable infant populations, we found only one study in which researchers reported measuring OT in the saliva of premature infants (Kommers et al, 2017).…”

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confidence: 99%

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Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Weber

Harrison

Sinnott

et al. 2017

Biological Research For Nursing

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Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. However, no studies have measured OT in the plasma and urine of premature infants. The purposes of this study were to describe plasma and urine OT levels of premature infants through 34 weeks corrected gestational age (CGA), determine whether plasma and urine OT are correlated, and explore associations between infant demographics and OT trajectories. Plasma and urine from 37 premature infants, born at gestational ages 25–28 6/7 weeks, were longitudinally collected at 14 days of life, then weekly until 34 weeks CGA. Plasma OT decreased with age, at a rate of 15% per week, and exhibited strong stability within infants. Urine OT was not correlated with plasma OT and did not show a significant trend over time; thus, urine may not be a reliable, noninvasive measurement in this population. Apgar score was the only infant demographic characteristic associated with plasma OT. Given the novelty of this work, replication is needed to confirm these findings, and future research should explore potential mechanisms (e.g., stress, normal maturation, and social experiences) that contribute to declining plasma OT levels in premature infants.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Weber

Harrison

Sinnott

et al. 2017

Biological Research For Nursing

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“…Oxytocin release increases during labor and lactation. However, oxytocin release decreases at cesarean delivery compared to vaginal delivery [24,25]. Moreover, oxytocin has shown anti-proliferative effects in several cancers as well as in breast cancer cells [26–28].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-Associated Risk Factors of Postpartum Breast Cancer in Korea: A Nationwide Health Insurance Database Study

et al. 2016

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Patients with postpartum breast cancer have been reported to have a poor prognosis. The present study aimed to evaluate the pregnancy-related risk factors of postpartum breast cancer in Korea. We collected patient data from the Korea National Health Insurance (KNHI) Claims Database of the Health Insurance Review and Assessment Service (HIRA) for the 2009–2013 period. We evaluated the pregnancy-related risk factors for postpartum breast cancer in two population groups. For Group 1 (women who had given birth during the 2010–2012 period), data on those who were diagnosed with breast cancer from childbirth to 1-year postpartum were extracted. For Group 2, we extracted the data of women who gave birth in 2010 and traced them until December 31, 2013. In Group 1, 1,384,551 deliveries and 317 postpartum breast cancer patients were recorded in Korea between January 1, 2010, and December 31, 2012. Women aged ≥35 years (Odds Ratio [OR], 2.003; 95% Confidence Interval [CI], 1.567–2.560) and those who gave birth via cesarean delivery (OR, 1.237; 95% CI, 0.986–1.553) were considered to be at a higher risk for breast cancer. Lower risk was noted in primiparous women (OR, 0.737; 95% CI, 0.585–0.928). In Group 2, the data of 457,924 women who gave birth in 2010 were traced until December 31, 2013. Among them, 655 patients were diagnosed with breast cancer, and age ≥35 years and cesarean delivery were associated with an higher risk of breast cancer, whereas primiparous status was associated with a lower risk of breast cancer. In conclusion, older age (≥35 years) and cesarean delivery are significant risk factors for postpartum breast cancer, and primiparous women have a lower risk of developing postpartum breast cancer.

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“…Parturition is an important developmental time-point with exposure to high levels of maternal OXT (Kuwabara et al, 1987; Douglas et al, 2002; Tyzio et al, 2006; Khazipov et al, 2008; Mazzuca et al, 2011). Prenatal binding of this OXTR ligand has not been examined in the whole embryo.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

Hammock

2013

Front. Behav. Neurosci.

100

132

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Oxytocin (OXT) has drawn increasing attention as a developmentally relevant neuropeptide given its role in the brain regulation of social behavior. It has been suggested that OXT plays an important role in the infant brain during caregiver attachment in nurturing familial contexts, but there is incomplete experimental evidence. Mouse models of OXT system genes have been particularly informative for the role of the OXT system in social behavior, however, the developing brain areas that could respond to ligand activation of the OXT receptor (OXTR) have yet to be identified in this species. Here we report new data revealing dynamic ligand-binding distribution of OXTR in the developing mouse brain. Using male and female C57BL/6J mice at postnatal days (P) 0, 7, 14, 21, 35, and 60 we quantified OXTR ligand binding in several brain areas which changed across development. Further, we describe OXTR ligand binding in select tissues of the near-term whole embryo at E18.5. Together, these data aid in the interpretation of findings in mouse models of the OXT system and generate new testable hypotheses for developmental roles for OXT in mammalian systems. We discuss our findings in the context of developmental disorders (including autism), attachment biology, and infant physiological regulation.Summary: Quantitative mapping of selective OXTR ligand binding during postnatal development in the mouse reveals an unexpected, transient expression in layers II/III throughout the mouse neocortex. OXTR are also identified in several tissues in the whole late embryo, including the adrenal glands, brown adipose tissue, and the oronasal cavity.

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Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine

Cited by 60 publications

References 15 publications

Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Pregnancy-Associated Risk Factors of Postpartum Breast Cancer in Korea: A Nationwide Health Insurance Database Study

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

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