Oxytocin inhibits proliferation of human breast cancer cell lines

Cassoni, Paola; Sapino, Anna; Negro, F.; Bussolati, G.

doi:10.1007/bf00197549

Cited by 74 publications

(79 citation statements)

References 22 publications

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“…Oxytocin, produced during pregnancy, delivery and breastfeeding, may have a role in the control of mammary cell growth [29] and inhibiting proliferation of human BCa cells, which may offer BCa prevention and treatment [30]. These findings have driven a hypothesis that oxytocin may have therapeutic effects on cancer [28].…”

Section: Discussionmentioning

confidence: 99%

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

You¹,

Symonds²,

Rühli³

et al. 2018

ABCR

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Purpose: Urbanization, obesity and ageing associated with lifestyle changes (Westernized diet patterns, pollution, physical inactivity) have been proposed as the major contributing factors for the global rise in breast cancer (BCa) and have been the variables used to predict the future breast cancer rate. At the same time, socio-economic level, instead of birth rate, has been proposed for explanation of dramatic regional variations of breast cancer incidence. We sought to determine which factor plays the determining role in predicting worldwide breast cancer incidence rates and regional variations. Methods: Bivariate correlation was conducted to examine the relationships between country-specific estimates of birth rate, BCa incidence, urbanization, overweight, ageing and GDP. Partial correlation was performed to identify the correlation between BCa incidence with each independent variable while we controlled the other four variables. Multiple linear regression was used to identify the most significant predictors of BCa incidence. Post hoc Scheff and independent T-Test analysis were performed to compare mean differences in BCa incidence rates and residuals of BCa standardised on birth rate in the WHO regions, and UN developed and developing regions respectively. Results: Worldwide, BCa incidence rate tends to increase while birth rate decreases and urbanization, overweight, ageing and GDP increase. However, birth rate was the only variable that had a significant correlation with BCa incidence when controlled for the other four variables. Birth rate was the only significant predictor of BCa incidence in regression analysis. Multiple mean differences of BCa incidence between regions were significant, but all disappeared when the contributing effect of birth rate on BCa incidence rate was removed. Conclusions: Birth rate plays a determining role in worldwide BCa incidence rate and regional variations. Current BCa projection methods may estimate future rates of BCa poorly if they fail to incorporate the impact of birth rate.

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Section: Discussionmentioning

confidence: 99%

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

You¹,

Symonds²,

Rühli³

et al. 2018

ABCR

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“…In breast cancer, in vitro effects of OT on cell proliferation vary from antiproliferative to mitogenic (26,28,47,48). In choriocarcinoma, OT promotes cell growth (30), whereas it decreases proliferation of glial tumors, endometrial adenocarcinomas, and neuroblastomas (23,27).…”

Section: Discussionmentioning

confidence: 99%

Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung

et al. 2005

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“…All of the cells were grown as monolayers in RPMI medium (Gibco, Paisley, Scotland) with 10% fetal calf serum (Gibco) in 25 cm 2 T flasks in a 5% CO 2 humidified atmosphere at 371C. Previous experiments have shown that MCF7, MOG-U-V-W and TS/A cells are OTR positive (Cassoni et al, 1994(Cassoni et al, , 1998; the KATO cells acted as an OTR-negative control.…”

Section: Binding Studies On Tumour Cellsmentioning

confidence: 99%

“…The oxytocin (OT) hypothalamic nonapeptide binds to various tumour types via the oxytocin receptor (OTR), a member of the seven transmembrane spanning family of G-protein-coupled receptors (Kimura et al, 1992;Gimpl and Fahrenholz, 2001). The tumoral expression of OTRs was first described in human breast cancer cell lines (Cassoni et al, 1994) and a large percentage of primary breast cancers (Bussolati et al, 1996). OTRs have recently also been detected in tumours of the nervous system such as neuroblastomas and glioblastomas (Cassoni et al, 1998), osteosarcomas (Novak et al, 2000), chorioncarcinomas , small cell lung carcinomas (Pequeux et al, 2002) and Kaposi sarcomas .…”

mentioning

confidence: 99%

Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue

et al. 2003

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Oxytocin receptors (OTR) have been described in a number of tumours of different origin, and represent a new target for specific radiolabelled oxytocin (OT) analogues in cancer diagnosis and therapy. By linking the DOTA chelating agent to position 8 of the deamino derivative of Lys 8 -vasotocin (dLVT), we obtained a new compound (DOTA-dLVT) with the following characteristics: (1) it forms a monomeric and stable compound that binds to OTR with an affinity comparable to that of the endogenous OT ligand; (2) it is characterised by a very good selectivity profile for the human OTR, with a low affinity binding to the closely related V1a, V1b and V2 vasopressin receptor subtypes; (3) it induces rapid and persistent receptor internalisation and (4) when radiolabelled, [ 111 In]-DOTA-dLVT is efficiently and selectively taken up by OTR-positive tumours grown in mice. These features makes radiolabelled DOTA-dLVT a very good candidate for the radiotargeting of OTR-expressing tumours.

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Oxytocin inhibits proliferation of human breast cancer cell lines

Cited by 74 publications

References 22 publications

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung

Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue

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