Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord

Oti, Takumi; Satoh, Keita; Uta, Daisuke; Nagafuchi, Junta; Tateishi, Sayaka; Ueda, Ryota; Takanami, Keiko; Young, Larry J.; Galione, Antony; Morris, John F.; Sakamoto, Tatsuya; Sakamoto, Hirotaka

doi:10.1016/j.cub.2020.09.089

Cited by 51 publications

(74 citation statements)

References 86 publications

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“…Indeed, recent evidence shows that oxytocin neurons of the SON secrete oxytocin from dendrites [ 95 ], and that dendritic secretion of oxytocin from SON neurons in the medial amygdala is essential for social recognition memory [ 96 ]. Furthermore, oxytocin is released from axonal varicosities originating from the PVH where they diffuse through the extracellular space to activate gastrin-releasing peptide neurons of the lumbar sacral spinal cord to modulate male sexual arousal [ 97 ]. Together these findings demonstrate that volume transmission of oxytocin is a relevant mode of communication for modulating physiological processes.…”

Section: Volume Transmission Of Oxytocinmentioning

confidence: 99%

Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

Liu

Spaulding

Rea

et al. 2021

IJMS

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The neuropeptide oxytocin is produced in the paraventricular hypothalamic nucleus and the supraoptic nucleus of the hypothalamus. In addition to its extensively studied influence on social behavior and reproductive function, central oxytocin signaling potently reduces food intake in both humans and animal models and has potential therapeutic use for obesity treatment. In this review, we highlight rodent model research that illuminates various neural, behavioral, and signaling mechanisms through which oxytocin’s anorexigenic effects occur. The research supports a framework through which oxytocin reduces food intake via amplification of within-meal physiological satiation signals rather than by altering between-meal interoceptive hunger and satiety states. We also emphasize the distributed neural sites of action for oxytocin’s effects on food intake and review evidence supporting the notion that central oxytocin is communicated throughout the brain, at least in part, through humoral-like volume transmission. Finally, we highlight mechanisms through which oxytocin interacts with various energy balance-associated neuropeptide and endocrine systems (e.g., agouti-related peptide, melanin-concentrating hormone, leptin), as well as the behavioral mechanisms through which oxytocin inhibits food intake, including effects on nutrient-specific ingestion, meal size control, food reward-motivated responses, and competing motivations.

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Section: Volume Transmission Of Oxytocinmentioning

confidence: 99%

Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

Liu

Spaulding

Rea

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Hypothalamic AVP and OXT are the primary source of peripheral release of these peptides, where they modulate a variety of physiological functions, including osmotic balance and blood pressure, and parturition and lactation, respectively ( 16-19 ). In addition, OXT and AVP neurons project throughout the central nervous system where peptide release can modify neuronal function either through volume or synaptic transmission ( 20 , 21 ).…”

Section: Sociocognitive and Reward Signaling In Attachmentmentioning

confidence: 99%

Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia

Loth

Donaldson

2020

Endocrinology

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Pair bonds represent some of the strongest attachments we form as humans. These relationships positively modulate health and well-being. Conversely, the loss of a spouse is an emotionally painful event that leads to numerous deleterious physiological effects, including increased risk for cardiac dysfunction and mental illness. Much of our understanding of the neuroendocrine basis of pair bonding has come from studies of monogamous prairie voles (Microtus ochrogaster), laboratory-amenable rodents that, unlike laboratory mice and rats, form lifelong pair bonds. Specifically, research using prairie voles has delineated a role for multiple neuromodulatory and neuroendocrine systems in the formation and maintenance of pair bonds, including the oxytocinergic, dopaminergic, and opioidergic systems. However, while these studies have contributed to our understanding of selective attachment, few studies have examined how interactions among these 3 systems may be essential for expression of complex social behaviors, such as pair bonding. Therefore, in this review, we focus on how the social neuropeptide, oxytocin, interacts with classical reward system modulators, including dopamine and endogenous opioids, during bond formation and maintenance. We argue that an understanding of these interactions has important clinical implications and is required to understand the evolution and encoding of complex social behaviors more generally. Finally, we provide a brief consideration of future directions, including a discussion of the possible roles that glia, specifically microglia, may have in modulating social behavior by acting as a functional regulator of these 3 neuromodulatory systems.

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“…This contrasts with the literature 34‐37 suggesting that VP reaches its target structures through diffusion and indicates that further investigation is required to resolve which mechanism dominates and for what physiological process or behaviour.…”

Section: Vp As a Neurotransmittermentioning

confidence: 63%

“…Evidence suggesting that VP or OT may transmit information via diffusion comes from observations of dense‐core vesicles undergoing exocytosis outside the classical synaptic areas, in both dendrites 34 and axons 35,36 . Consequently, peptide release observed after stimulation of the SON area 37 was attributed to non‐synaptic release.…”

Section: Vp As a Diffusible Messenger In The Cnsmentioning

confidence: 99%

Vasopressin: An output signal from the suprachiasmatic nucleus to prepare physiology and behaviour for the resting phase

Buijs

Hurtado‐Alvarado

Soto‐Tinoco

2021

J Neuroendocrinology

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In vertebrates, vasopressin (VP), also known as antidiuretic hormone, and oxytocin (OT) are released from the neural lobe of the pituitary gland into the general circulation. The classic hormonal role of OT is to modulate parturition and lactation, 1 whereas VP regulates plasma osmolarity through water and ion excretion. 2 Therefore, despite the sequence similarity between these peptides, they have very welldifferentiated functions.Three G-coupled receptors for VP have been cloned, which account for VP pressor functions (AVPR1a, G q ), antidiuretic functions (AVPR2, G s ) and adrenocorticotrophin-releasing effects (VPR1b,

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Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord

Cited by 51 publications

References 86 publications

Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia

Vasopressin: An output signal from the suprachiasmatic nucleus to prepare physiology and behaviour for the resting phase

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