Oxytocin induces penile erection when injected into the ventral subiculum: Role of nitric oxide and glutamic acid

Melis, Maria Rosaria; Succu, Salvatora; Cocco, Cristina; Caboni, E.; Sanna, Fabrizio; Boi, Antonio; Ferri, Gian Luca; Argiolas, Antonio

doi:10.1016/j.neuropharm.2010.02.008

Cited by 21 publications

(39 citation statements)

References 47 publications

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“…This may occur also in humans, because plasma oxytocin is increased by sexual stimuli, especially at ejaculation (Carmichael et al, 1987;Murphy et al, 1987). Oxytocin induces penile erection not only when injected into the lateral cerebral ventricle and the PVN but also in other extrahypothalamic brain regions, such as the ventral tegmental area (Melis et al, 2007(Melis et al, , 2009Succu et al, 2008), the ventral subiculum of the hippocampus, and the posterior nucleus of the amygdala (Melis et al, 2009(Melis et al, , 2010, which are important constituents of the limbic system and are thought to play a key role in motivation and reward processes. The erectile response was blocked by oxytocin antagonists and by electrolytic lesion of the PVN.…”

Section: Oxytocinmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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Section: Oxytocinmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…En machos está implicada en: el funcionamiento eréctil (Melis et al, 2010;Succu et al, 2008;Melis et al, 2007), la actividad copulatoria y la eyaculación (Gil, Bhatt, Picotte, & Hull, 2011). Es importante aclarar que la OT no actúa de forma individual, ésta debe interactuar con otras hormonas como por ejemplo la testosterona, pues si un macho se encuentra castrado a pesar de suministrarle OT no podrá tener erecciones (Connor & Heithaus, 1996).…”

Section: Comportamiento Sexualunclassified

Rol Modulador de la Oxitocina en la Interacción Social y el Estrés Social

Acevedo

Parra

2017

Univ Psychol

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RESUMENLa Oxitocina es un neuropéptido conocido por facilitar funciones del sistema nervioso periférico, relacionadas específicamente con el sistema reproductivo. Sin embargo, en las últimas décadas se ha reconocido la función moduladora de la Oxitocina en el comportamiento social, a través de su liberación en el sistema nervioso central. Así mismo, estudios han mencionado que la Oxitocina es un potencial ansiolítico cuando un individuo ha sido sometido a estrés social. Por lo tanto, el objetivo de esta revisión es presentar una caracterización de la Oxitocina y su relación con distintas formas de interacción social y el estrés social; a través de los resultados presentados en distintos estudios, tanto en modelos animales como en humanos. Además, se intenta mostrar la importancia de continuar con el estudio de la Oxitocina, dados los posibles vacíos teóricos y experimentales existentes, teniendo en cuenta las potenciales cualidades ansiolíticas de esta hormona. Palabras claveOxitocina; Interacción social; Estrés social; Ansiedad. ABSTRACTOxytocin, a neuropeptide, is known to allow peripheral nervous system functions related specifically to the reproductive system. However, the modulatory function of Oxytocin in social behavior has been recognized in the last decades through its release in the central nervous system. Likewise, some studies have mentioned that Oxytocin is a promising anxiolytic when an individual has been exposed to social stress. Therefore, the objective in this review is to show a characterization of Oxytocin and its relationship with both social interactions and social stress, through results of studies in both animals and humans. Also, this review intends to show the importance of furthering the study of Oxytocin due to the theoretical and experimental voids in its current research, knowing the potential anxiolytic qualities of this hormone.

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Section: Sexual Behaviourmentioning

confidence: 99%

“…The ability of oxytocin to induce erection is abolished by nitric oxide (NO) synthase inhibitors suggesting that oxytocin activates NO-synthase activity in the hippocampus (35). NO in turn activates glutaminergic neurotransmission (35). Inhibition of oxytocin with oxytocin antagonists reduced the number of mounts and intromissions in male rats, implicating a role for oxytocin in inducing male sexual behaviour (36).…”

Section: Sexual Behaviourmentioning

confidence: 99%

Oxytocin: recent developments

Tom

Assinder

2010

BioMolecular Concepts

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Oxytocin is a neurohypophyseal hormone that is produced centrally by neurons in the paraventricular nucleus and supraoptic nucleus of the hypothalamus. It is released directly into higher brain centres and into the peripheral circulation where it produces a multitude of effects. Classically, oxytocin is known for inducing uterine contractions at parturition and milk ejection during suckling. Oxytocin also acts in a species and gender specific manner as an important neuromodulator. It can affect behaviours associated with stress and anxiety, as well social behaviours including sexual and relationship behaviours, and maternal care. Additionally, oxytocin has been shown to have a variety of physiological roles in peripheral tissues, many of which appear to be modulated largely by locally produced oxytocin, dispelling the notion that oxytocin is a purely neurohypophyseal hormone. Oxytocin levels are altered in several diseases and the use of oxytocin or its antagonists have been identified as a possible clinical intervention in the treatment of mood disorders and pain conditions, some cancers, benign prostatic disease and osteoporosis. Indeed, oxytocin has already been successful in clinical trials to treat autism and schizophrenia. This review will report briefly on the known functions of oxytocin, it will discuss in depth the data from recent clinical trials and highlight future targets for oxytocinergic modulation.

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Oxytocin induces penile erection when injected into the ventral subiculum: Role of nitric oxide and glutamic acid

Cited by 21 publications

References 47 publications

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Rol Modulador de la Oxitocina en la Interacción Social y el Estrés Social

Oxytocin: recent developments

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