Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse

Schorscher-Petcu, Ara; Sotocinal, Susana G.; Ciura, Sorana; Dupré, Anouk; Ritchie, Judith A.; Sorge, Robert E.; Crawley, Jacqueline N.; Hu, Shuang Bao; Nishimori, Katsuhiko; Young, Larry J.; Tribollet, Eliane; Quirion, Rémi; Mogil, Jeffrey S.

doi:10.1523/jneurosci.1594-10.2010

Cited by 164 publications

(150 citation statements)

References 78 publications

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“…Future studies are needed to elucidate the exact neurochemical cascade underlying the observed OXT effect on approach behavior since OXT-induced analgesia in mice, for example, is mediated by vasopressin-1A receptors (Schorscher-Petcu et al, 2010). Similarly, an analysis of which of the various aspects of a pair-bond potentially interact with OXT to promote fidelity in monogamous males may constitute a promising approach to explore the fascinating, albeit tremendously complex, neurobiology of human pair-bonding.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Modulates Social Distance between Males and Females

et al. 2012

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In humans, interpersonal romantic attraction and the subsequent development of monogamous pair-bonds is substantially predicted by influential impressions formed during first encounters. The prosocial neuropeptide oxytocin (OXT) has been identified as a key facilitator of both interpersonal attraction and the formation of parental attachment. However, whether OXT contributes to the maintenance of monogamous bonds after they have been formed is unclear. In this randomized placebo-controlled trial, we provide the first behavioral evidence that the intranasal administration of OXT stimulates men in a monogamous relationship, but not single ones, to keep a much greater distance (ϳ10 -15 cm) between themselves and an attractive woman during a first encounter. This avoidance of close personal proximity occurred in the physical presence of female but not male experimenters and was independent of gaze direction and whether the female experimenter or the subject was moving. We further confirmed this unexpected finding using a photograph-based approach/ avoidance task that showed again that OXT only stimulated men in a monogamous relationship to approach pictures of attractive women more slowly. Importantly, these changes cannot be attributed to OXT altering the attitude of monogamous men toward attractive women or their judgments of and arousal by pictures of them. Together, our results suggest that where OXT release is stimulated during a monogamous relationship, it may additionally promote its maintenance by making men avoid signaling romantic interest to other women through close-approach behavior during social encounters. In this way, OXT may help to promote fidelity within monogamous human relationships.

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Section: Discussionmentioning

confidence: 99%

Oxytocin Modulates Social Distance between Males and Females

et al. 2012

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“…Studies in rodents have found that the effects of OT on some social behavior and cognition (e.g., social communication) are mediated by AVP1A receptors (41,42). AVP1A receptors are densely located in the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mammillary bodies, but are also found in the amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus, and brainstem (43).…”

Section: Ot Reduces Brain Activity Evoked By Negative Emotional Stimulimentioning

confidence: 99%

Oxytocin modulates fMRI responses to facial expression in macaques

Liu¹,

Hadj-Bouziane²,

Jones³

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Increasing evidence has shown that oxytocin (OT), a mammalian hormone, modifies the way social stimuli are perceived and the way they affect behavior. Thus, OT may serve as a treatment for psychiatric disorders, many of which are characterized by dysfunctional social behavior. To explore the neural mechanisms mediating the effects of OT in macaque monkeys, we investigated whether OT would modulate functional magnetic resonance imaging (fMRI) responses in face-responsive regions (faces vs. blank screen) evoked by the perception of various facial expressions (neutral, fearful, aggressive, and appeasing). In the placebo condition, we found significantly increased activation for emotional (mainly fearful and appeasing) faces compared with neutral faces across the faceresponsive regions. OT selectively, and differentially, altered fMRI responses to emotional expressions, significantly reducing responses to both fearful and aggressive faces in face-responsive regions while leaving responses to appeasing as well as neutral faces unchanged. We also found that OT administration selectively reduced functional coupling between the amygdala and areas in the occipital and inferior temporal cortex during the viewing of fearful and aggressive faces, but not during the viewing of neutral or appeasing faces. Taken together, our results indicate homologies between monkeys and humans in the neural circuits mediating the effects of OT. Thus, the monkey may be an ideal animal model to explore the development of OT-based pharmacological strategies for treating patients with dysfunctional social behavior.oxytocin | neuroimaging | nonhuman primate | social stimuli I n the last decade, oxytocin (OT), a mammalian hormone, has become one of the most studied peptides of the neuroendocrine system. In humans, accumulating evidence has demonstrated that OT affects a wide range of social behavior and cognition, including perception, recognition and memory of social stimuli (1-5), socially reinforced learning (6), and more complex sociocognitive behaviors [e.g., trust (7,8), cooperation (9), generosity (10), and empathy (6, but see ref. 11)]. Therefore, it has been proposed that OT may serve as a treatment for various disorders with dysfunctional social behavior, such as autism spectrum disorders, antisocial personality disorder, and schizophrenia (for review, see ref. 12). A recent study found that OT enhances brain activity for socially meaningful stimuli but attenuates activity for nonsocially meaningful stimuli in children with autism spectrum disorders (13). Although these studies suggest very promising prospects of OT for clinical use, the neural mechanisms underlying OT's modulatory effects remain elusive. To understand these mechanisms, it is important to investigate the effect of OT on brain activity, especially in regions involved in social behavior and cognition.Functional magnetic resonance imaging (fMRI) has been the major approach to investigating altered brain activation patterns in response to OT in humans. OT may affect the per...

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“…For instance, in male prairie voles (Microtus ochrogaster), septal VP promotes partner preference via OTRs (10), OT induces analgesia in mice via V1aRs (11), and Ile 3 -VP (vasotocin, the nonmammalian form of VP) promotes oviposition in birds via OTRs (12 (13). No fewer than 14 terms are currently used to identify the numerous VP and OT variants, and thus for clarity, we here use "VP" and "OT" to refer to all known homologs of the canonical mammalian forms.…”

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confidence: 99%

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Kelly

Goodson

2014

Proc. Natl. Acad. Sci. U.S.A.

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Antagonism of oxytocin (OT) receptors (OTRs) impairs the formation of pair bonds in prairie voles (Microtus ochrogaster) and zebra finches (Taenioypygia guttata), and also reduces the preference for the larger of two groups ("gregariousness") in finches. These effects tend to be stronger in females. The contributions of specific peptide cell groups to these processes remain unknown, however. This issue is complicated by the fact that OTRs in finches and voles bind not only forms of OT, but also vasopressin (VP), and >10 cell groups produce each peptide in any given species. Using RNA interference, we found that knockdown of VP and OT production in the paraventricular nucleus of the hypothalamus exerts diverse behavioral effects in zebra finches, most of which are sexually differentiated. Our data show that knockdown of VP production significantly reduces gregariousness in both sexes and exerts sexspecific effects on aggression directed toward opposite-sex birds (increases in males; decreases in females), whereas OT knockdown produces female-specific deficits in gregariousness, pair bonding, and nest cup ownership; reduces side-by-side perching in both sexes; modulates stress coping; and induces hyperphagia in males. These findings demonstrate that paraventricular neurons are major contributors to the effects of VP-OT peptides on pair bonding and gregariousness; reveal previously unknown effects of sex-specific peptide on opposite-sex aggression; and demonstrate a surprising lack of effects on same-sex aggression. Finally, the observed effects of OT knockdown on feeding and stress coping parallel findings in mammals, suggesting that OT modulation of these processes is evolutionarily conserved across the amniote vertebrate classes.vasotocin | mesotocin | social behavior N umerous pharmacological studies, such as those using sitespecific infusions of agonists and antagonists, have demonstrated that the vasopressin (VP)-oxytocin (OT) nonapeptides modulate diverse behaviors, including parental care, aggression, communication, sexual behavior, affiliation, anxiety, pair bonding, and stress response (1-3). Such manipulations do not allow us to infer the functions of specific VP-OT neuronal populations, however, because the peptides are produced in numerous cell groups, at least some of which give rise to widespread and longdistance paracrine modulation, including release from axons, dendrites, and soma (4-6). The various VP-OT cell groups also exhibit overlapping axonal projections, and thus any given brain area potentially receives peptides from many different sources (4). Indeed, there is an extremely high potential for overlapping modulation from the various cell groups, because numerous brain areas produce OT and VP in any given species. For instance, 20 different forebrain areas produce OT in the mustached bat (Pteronotus parnellii) (7), and sites of VP production are comparably numerous (8). Importantly, even the smallest of these populations, such as the accessory VP populations of the anterior hypothalamus (AH)...

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Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse

Cited by 164 publications

References 78 publications

Oxytocin Modulates Social Distance between Males and Females

Oxytocin Modulates Social Distance between Males and Females

Oxytocin modulates fMRI responses to facial expression in macaques

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

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