Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.

Louvel, Dominique; Delvaux, Michel; Felez, A; Fioramonti, Jean; Buéno, Lionel; Lazorthes, Y; Frexinos, Jacques

doi:10.1136/gut.39.5.741

Cited by 95 publications

(91 citation statements)

References 36 publications

(15 reference statements)

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“…For instance, intranasal OXY can reduce the pain from chronic constipation, 26 and intravenous OXY increases the pain threshold to colonic distention in irritable bowel syndrome. 27 In addition, in somatic studies, both chronic and acute low back pain were significantly relieved following the intrathecal administration of OXY. 8 While these data indicate that OXY may be an effective analgesic in humans, the report is lacking in a number of important details, including a description of the participants' back pain and the duration of the OXY effect.…”

Section: Discussionmentioning

confidence: 99%

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Engle

Ness

Robbins

2013

Obstetric Anesthesia Digest

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Section: Discussionmentioning

confidence: 99%

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Engle

Ness

Robbins

2013

Obstetric Anesthesia Digest

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“…(Liu et al, 2002), i.p. (Agren et al, 1997), and intracisternal administration of OT (Arletti et al, 1993), as well as direct injections of OT to the PAG and the nucleus raphe magnus (Robinson et al, 2002), induced antinociceptive effects in animals and humans (Arletti et al, 1993;Lundeberg et al, 1994;Louvel et al, 1996;Petersson et al, 1996;Agren et al, 1997;Caron et al, 1998;Kang and Park, 2000). The involvement of opioid receptors in OT-induced antinociception in the CNS has also been investigated (Wang et al, 2003;Zubrzycka et al, 2005).…”

Section: Modulation Of Serotonin Transmissionmentioning

confidence: 99%

The Endomorphin System and Its Evolving Neurophysiological Role

Fichna

Janecka²,

Costentin³

et al. 2007

Pharmacol Rev

219

171

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“…For instance oxytocin in placebo controlled trials was shown to reduce the severity of headache and colonic visceral perception in irritable bowel syndrome (Louvel et al, 1996) but produced no beneficial effect in fibromyalgia (Mameli et al, 2014) or pain in chronic constipation (Ohlsson et al, 2005). While oxytocin has been reported to reduce pain and unpleasantness in the cold pressor test and acute laser evoked thermal pain (Paloyelis et al, 2016b) other experimental pain models have not shown a clear anti-nociceptive effect (Kessner et al, 2013;Zunhammer et al, 2015).…”

Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

et al. 2017

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Low intensity, non-noxious, stimulation of cutaneous somatosensory nerves has been shown to trigger oxytocin release and is associated with increased social motivation, plus reduced physiological and behavioural reactivity to stressors. However, to date, little attention has been paid to the specific nature of the mechanosensory nerves which mediate these effects. In recent years, the neuroscientific study of human skin nerves (microneurography studies on single peripheral nerve fibres) has led to the identification and characterisation of a class of touch sensitive nerve fibres named C-Tactile afferents. Neither itch nor pain receptive, these unmyelinated, low threshold mechanoreceptors, found only in hairy skin, respond optimally to low force/velocity stroking touch. Notably, the speed of stroking which c-tactile afferents fire most strongly to is also that which people perceive to be most pleasant. The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions. In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive affective value and, under healthy conditions, inhibits responses to painful stimuli. These effects mirror those, we also review, which have been reported following endogenous release and exogenous administration of oxytocin. Taken together this evidence suggests c-tactile afferent stimulation may mediate oxytocin release during affiliative tactile interactions.

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Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.

Cited by 95 publications

References 36 publications

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

The Endomorphin System and Its Evolving Neurophysiological Role

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

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