Oxytocin in the Circadian Timing of Birth

Roizen, Jeffrey D.; Luedke, Christina; Herzog, Erik D.; Muglia, Louis J.

doi:10.1371/journal.pone.0000922

Cited by 45 publications

(35 citation statements)

References 14 publications

(17 reference statements)

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“…OT is released in a circadian fashion. This rhythmicity of secretion is not altered in wild-type gravid females upon change in light:dark cycle although both wild-type and OT Ϫ/Ϫ dams shift their locomotor activity patterns in response to the disturbance (75). Therefore, it seems OT secretion may maintain the onset of labor with original circadian entrainment of pregnancy (75).…”

Section: Circadian Influence On Labormentioning

confidence: 90%

“…The Clock mutant mouse, which has a deletion in Clock's transcriptional activation domain, has been noted to have a high incidence of extended but nonproductive labor indicating a role for genes of the molecular clock in the parturition process (74). In addition, we recently reported a possible role for OT in maintaining the normal circadian gating of labor in mice (75). A 6-h phase advance or delay in wild-type dams starting on d 4.5 of gestation precipitated no overall change in birth timing, whereas the same 6-h phase advance or delay in OT Ϫ/Ϫ dams leads to a random scattering of the time of birth throughout the day (75).…”

Section: Circadian Influence On Labormentioning

confidence: 94%

“…In addition, we recently reported a possible role for OT in maintaining the normal circadian gating of labor in mice (75). A 6-h phase advance or delay in wild-type dams starting on d 4.5 of gestation precipitated no overall change in birth timing, whereas the same 6-h phase advance or delay in OT Ϫ/Ϫ dams leads to a random scattering of the time of birth throughout the day (75). OT is released in a circadian fashion.…”

Section: Circadian Influence On Labormentioning

confidence: 99%

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Insights Into Parturition Biology From Genetically Altered Mice

Ratajczak

Muglia

2008

Pediatr Res

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ABSTRACT:With the growing frequency of preterm birth, increased effort has been made to elucidate the physiology of normal and aberrant parturition. As with many developmental processes, the study of genetically altered mice has led to an increased understanding of mechanisms controlling the maintenance and resolution of pregnancy. Studies in genetically altered mice have implicated critical roles for both prostaglandin synthesis and degradation in luteolysis and the progression of labor. The importance of local modulation of progesterone activity to cervical ripening has also been demonstrated. Although a decline in levels of serum progesterone is a part of normal labor initiation in mice but not humans, murine labor without progesterone withdrawal has been reported in some cases. These findings emphasize the importance of other components of the parturition cascade that are shared in mice and humans and highlights the importance of an increased understanding of the physiology of mouse parturition. (Pediatr Res 64: 581-589, 2008) P arturition is the culmination of mammalian reproduction, a task essential for survival of the species. After a period of uterine quiescence to allow fetal growth and development, changes occur in myometrial contractility that result in efficient expulsion of the fetus. These events have likely evolved to enhance survival of both the fetus and the mother. The nature of these pathways, however, is at best incompletely defined.Increased knowledge of the cascade of events that occur at parturition may lead to advances in combating preterm labor (PTL) or optimization of protocols for medically induced labor. As preterm birth is associated with both increased risk of neonatal mortality and chronic sequelae such as respiratory illness, cerebral palsy, and vision and hearing impairment, it is a major public health concern (1). In the United States, 12.7% of births are preterm (2). Although approximately 50% of preterm births are idiopathic (3), genetic factors seem to be important. Women whose mothers or sisters delivered preterm are at increased risk for premature labor (4,5), indicating a genetic component in the timing of labor. In addition, a study of a Utah population indicates greater genetic relatedness between families with preterm deliveries than control families (6). Because the population studied was descended from the people who established Mormonism in Utah and Mormons have low rates of substance abuse and sexually transmitted diseases, the population used in this study may represent individuals with few environmental risk factors for PTL (6). These studies highlight a role for genetic, and not just environmental factors in predisposition to PTL and serves as a call to researchers to identify and study genes important for parturition.The mouse is a useful research tool for dissecting genetic factors involved in developmental processes. Mice are tractable to genetic manipulation, resulting in an array of available and potential knockout and transgenic mice suitable for studying t...

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Section: Circadian Influence On Labormentioning

confidence: 90%

Section: Circadian Influence On Labormentioning

confidence: 94%

Section: Circadian Influence On Labormentioning

confidence: 99%

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Insights Into Parturition Biology From Genetically Altered Mice

Ratajczak

Muglia

2008

Pediatr Res

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“…At the heart of the circadian pacemaker resides a 40 transcriptional feedback loop, whereby the rhythmic transcription, translation and feedback of 41 a series of 'core clock' genes occurs over 24 hours (Shearman et al, 2000). The process 42 begins when the transcription factors CLOCK and BMAL1 heterodimerise, enter the nucleus 43 and by binding to an E-box (CACGTG) in the promoters, drive the transcription of the period 44 (Per1, Per2, Per3) and cryptochrome genes (Cry1, 2012). Together, these interlocked transcriptional feedback loops, which take 24 hours to 7 complete, provide the foundation for the establishment of molecular circadian rhythms 8 ( Figure 1).…”

Section: The Mammalian Circadian Timing System 27mentioning

confidence: 99%

Circadian regulation of reproduction: From gamete to offspring

Boden

Varcoe

Kennaway

2013

Progress in Biophysics and Molecular Biology

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“…Parturition, a key event for the survival of viviparous species, is a complex process involving myometrial activation, cervical ripening and membrane/decidual activation [6,25,30–32,36,74,94,107–109,111,129,134,137,139,148,150,157,177,184,189,190,194]. The myometrium is responsible for the contractile force required to propel the fetus through the birth canal.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor

Chaemsaithong¹,

Madan²,

Romero

et al. 2013

Journal of Perinatal Medicine

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Objective The molecular basis of failure to progress in labor is poorly understood. This study was undertaken to characterize the myometrial transcriptome of patients with an arrest of dilatation (AODIL). Study design Human myometrium was prospectively collected from women in the following groups: 1) spontaneous term labor (TL; n=29); and 2) arrest of dilatation (AODIL; n=14). Gene expression was characterized using Illumina® HumanHT-12 microarrays. A moderated student t-test and false discovery rate adjustment were used for analysis. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) of selected genes was performed in an independent sample set. Pathway analysis was performed on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database using Pathway Analysis with Down-weighting of Overlapping Genes (PADOG). The Metacore knowledge base was also mined for pathway analysis. Results 1) 42 genes differentially expressed were identified in women with an AODIL; 2) gene ontology analysis indicated enrichment of biological processes, which included: regulation of angiogenesis, response to hypoxia, inflammatory response, and chemokine-mediated signaling pathway. Enriched molecular functions included: transcription repressor activity, Heat shock protein (Hsp) 90 binding, and nitric oxide synthase (NOS) activity; 3) Metacore analysis identified immune response chemokine (C-C motif) ligand 2 (CCL2) signaling, muscle contraction regulation of eNOS activity in endothelial cells, and Triiodothyronine and Thyroxine signaling as significantly over-represented (FDR<0.05); 4) qRT-PCR confirmed overexpression of Nitric oxide synthase 3 NOS3; hypoxic ischemic factor (HIF1A), Chemokine (C-C motif) ligand 2 (CCL2); angiopoietin-like 4 (ANGPTL4), ADAM metallopeptidase with thrombospondin type 1, motif 9 (ADAMTS9), G protein-coupled receptor 4 (GPR4), metallothionein 1A (MT1A), MT2A, selectin E (SELE) in an AODIL. Conclusion The myometrium of women with arrest of dilatation have a stereotypic transcriptome profile. This disorder was associated with a pattern of gene expression involved in muscle contraction, an inflammatory response, and hypoxia. This is the first comprehensive and unbiased examination of the molecular basis of an AODIL.

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Oxytocin in the Circadian Timing of Birth

Cited by 45 publications

References 14 publications

Insights Into Parturition Biology From Genetically Altered Mice

Insights Into Parturition Biology From Genetically Altered Mice

Circadian regulation of reproduction: From gamete to offspring

Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor

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