Oxytocin Given as Iv Bolus Versus Iv Infusion in Women Undergoing Caesarean Sectiona Randomised, Controlled, Double-Blind Study

Abstract

BACKGROUNDOxytocin is the uterotonic of choice in the prevention of uterine atony. It reduces blood loss during both vaginal deliveries (1) and caesarean sections. Its prophylactic and therapeutic administration is justified, because it is said to reduce the incidence of PPH by about 40%. However, bolus use of oxytocin is known to cause cardiovascular effects including tachycardia, hypotension and ST changes. Aims and Objectives-To compare the uterine tone, blood loss and haemodynamic responses on intravenous administration of oxytocin 5 units given as IV bolus or IV infusion in women undergoing Caesarean section under sub-arachnoid block.

<p>A Randomized Control Trial of 3 IU IV Oxytocin Bolus with 7 IU Oxytocin Infusion versus 10 IU Oxytocin Infusion During Cesarean Section for Prevention of Postpartum Hemorrhage</p>

“…Studies conducted with the use of 5 IU have shown significant hemodynamic changes. 20 However, doses of 3 IU have not shown to cause statistically significant hemodynamic changes. 4 Various studies have used higher doses of Oxytocin infusion of 40 IU.…”

Randomised Control Trial of 3 IU Intravenous Oxytocin Bolus With 7 IU Oxytocin Infusion Versus 10 IU Intramuscular Oxytocin in the Third Stage of Labour in the Prevention of Postpartum Hemorrhage

“…The IV bolus dose of oxytocin is quicker in action in comparison to the IM route. The applied dose of IV bolus oxytocin in cesarean section (C-section) has been variable, including 10, 5, 3, 2, and 1 IU of IV oxytocin bolus (4)(5)(6)(7)(8).…”