Oxytocin diminishes heroin tolerance in mice

Kovaćs, Gábor L.; Faludi, Mária; Telegdy, Gyula

doi:10.1007/bf00432233

Cited by 38 publications

(17 citation statements)

References 9 publications

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“…It is possible that the dose of oxytocin utilized in the sub-chronic regimen was not optimal for persistent effects on repetitive behavior. Other studies examining oxytocin effects in animal models have reported bell-shaped dose response curves, with higher doses of oxytocin exhibiting less efficacy than more moderate doses (Arletti and Bertolini, 1987; Kovács et al, 1985). Further, the repetitive behavior analysis after sub-chronic oxytocin treatment was conducted at the 24-hour and 1-week time points, while the strongest prosocial oxytocin effects were observed at the 2-week time point.…”

Section: Discussionmentioning

confidence: 96%

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

et al. 2013

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Clinical evidence suggests that oxytocin treatment improves social deficits and repetitive behavior in autism spectrum disorders (ASDs). However, the neuropeptide has a short plasma half-life and poor ability to penetrate the blood-brain barrier. In order to facilitate the development of more bioavailable oxytocinergic compounds as therapeutics to treat core ASD symptoms, small animal models must be validated for preclinical screens. This study examined the preclinical utility of two inbred mouse strains, BALB/cByJ and C58/J, that exhibit phenotypes relevant to core ASD symptoms. Mice from both strains were intraperitoneally administered oxytocin, using either acute or sub-chronic regimens. Acute oxytocin did not increase sociability in BALB/cByJ; however, sub-chronic oxytocin had significant prosocial effects in both BALB/cByJ and C58/J. Increased sociability was observed 24 hours following the final oxytocin dose in BALB/cByJ, while prosocial effects of oxytocin emerged 1–2 weeks post-treatment in C58/J. Furthermore, acute oxytocin decreased motor stereotypy in C58/J and did not induce hypoactivity or anxiolytic-like effects in an open field test. This study demonstrates that oxytocin administration can attenuate social deficits and repetitive behavior in mouse models of ASD, dependent on dose regimen and genotype. These findings provide validation of the BALB/cByJ and C58/J models as useful platforms for screening novel drugs for intervention in ASDs and for elucidating the mechanisms contributing to the prosocial effects of oxytocin.

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Section: Discussionmentioning

confidence: 96%

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

et al. 2013

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“…In fact, for ethanol, one dose of OT or the administration of OT once tolerance was established, produced no effect on tolerance(80). In contrast, for opiates, a single dose before or after tolerance was established, was sufficient to reduce opiate tolerance to analgesia (62). Although tolerance is not necessary or sufficient for drug or alcohol dependence, the reversal of tolerance is important for the period of withdrawal and the effect of OT on this reversal seems to be drug- and context- dependent.…”

Section: Discussionmentioning

confidence: 99%

“…Intracerebroventricular (ICV) injections of OT reproduced these effects in reducing acute and chronic tolerance more potently as did direct delivery to the HC or NAc or administration of dipeptides derived from the C-terminal OT portion (60). Either single or repeated dosing of OT also inhibits tolerance to the acute and chronic analgesic effects of heroin (62). The effect of OT on heroin self-administration behavior is state dependent and is apparent only in tolerant animals where OT decreases both the acquisition and maintenance of self-administration behavior (63).…”

Section: Evidence That Ot Is Involved In the Response To Drugs Of mentioning

confidence: 99%

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

et al. 2016

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The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning and memory processes. As such there is increasing interest in oxytocin as a potential treatment for addictions. The oxytocin system is itself altered by acute or chronic exposure to drugs of abuse. A large number of preclinical studies in rodents have investigated the effect of oxytocin on various drug-induced behaviors to determine whether oxytocin can reverse the neuroadaptations occurring with repeated drug and alcohol use. In addition, the mechanisms by which oxytocin acts to modify the behavioral response to drugs of abuse are beginning to be understood. More recently, a few small clinical studies have been conducted in cocaine, cannabis and alcohol dependence. This review summarizes the preclinical as well as clinical literature to date on the oxytocin system and its relevance to drug and alcohol addiction.

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“…These findings suggest that oxytocin attenuated the development of heroin tolerance. Support for this idea comes from a follow up study showing that oxytocin pre-treatment diminished heroin tolerance in mice as measured by its anti-nociceptive effects (Kovacs, Faludi, & Telegdy, 1985). …”

Section: Oxytocin Effects On Preclinical Models Of Addictionmentioning

confidence: 99%

Oxytocin and Rodent Models of Addiction

Leong

Cox

King

et al. 2018

International Review of Neurobiology

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Interest for the use of oxytocin as a treatment for addiction began over 40years ago. Better known for its roles in parturition, lactation and pair bonding, oxytocin also has anxiolytic properties, reduces immune and inflammatory responses, and has a role in learning and memory. In this chapter, oxytocin effects on addiction processes are described by highlighting research findings that have used oxytocin within current preclinical animal models of addiction, relapse, or craving. First, we provide a brief background of the endogenous oxytocin system followed by descriptions of the behavioral models used to study addiction, including models of drug taking and seeking. Then we review recent preclinical studies that have used oxytocin as a therapeutic intervention throughout multiple stages of the addiction cycle from a behavioral and neurobiological perspective. These models encompass the entire range of the addiction cycle including acquisition and maintenance of drug taking, withdrawal and craving during periods of drug abstinence, and ultimately relapse. We then posit several theories about how oxytocin interacts with both drug and social reward, as well as presenting a mechanistic account of how specific oxytocin receptor localization may contribute to oxytocin's efficacy as an addiction therapeutic.

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Oxytocin diminishes heroin tolerance in mice

Cited by 38 publications

References 9 publications

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

Oxytocin and Rodent Models of Addiction

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