Oxytocin can impair memory for social and non-social visual objects: A within-subject investigation of oxytocin's effects on human memory

Herzmann, Grit; Young, Brent R.; Bird, Christopher; Curran, Tim

doi:10.1016/j.brainres.2012.02.049

Cited by 44 publications

(44 citation statements)

References 51 publications

(97 reference statements)

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“…Similarly, four of the five published studies on face recognition memory show positive effects in the predicted direction (Di Simplicio et al, 2009; Guastella et al, 2008b; Rimmele et al, 2009; Savaskan et al, 2008). A reverse effect was reported by Herzmann et al (2012). Thus, the over all pattern of result shows that OT enhances face processing and recognition.…”

Section: Introductionmentioning

confidence: 58%

Oxytocin eliminates the own-race bias in face recognition memory

et al. 2014

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The neuropeptide Oxytocin influences a number of social behaviors, including processing of faces. We examined whether Oxytocin facilitates the processing of out-group faces and reduce the own-race bias (ORB). The ORB is a robust phenomenon characterized by poor recognition memory of other-race faces compared to the same-race faces. In Experiment 1, participants received intranasal solutions of Oxytocin or placebo prior to viewing White and Black faces. On a subsequent recognition test, whereas in the placebo condition the same-race faces were better recognized than other-race faces, in the Oxytocin condition Black and White faces were equally well recognized, effectively eliminating the ORB. In Experiment 2, Oxytocin was administered after the study phase. The ORB resulted, but Oxytocin did not significantly reduce the effect. This study is the first to show that Oxytocin can enhance face memory of out-group members and underscore the importance of social encoding mechanisms underlying the own-race bias.

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Section: Introductionmentioning

confidence: 58%

Oxytocin eliminates the own-race bias in face recognition memory

et al. 2014

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“…While computational models of fear conditioning (i.e., Rescorla & Wagner, 1972) might suggest that enhancement of recall could be due to enhanced startle in the OT group during early extinction training, early extinction responses did not significantly correlate with recall scores, arguing against this explanation. Pro-cognitive effects of OT on other forms of memory are emerging, including facilitation of social memory (Striepens et al, 2011; Herzmann et al, 2012) and verbal learning in some cases (Feifel et al 2012; but see Heinrichs et al, 2004). …”

Section: Discussionmentioning

confidence: 99%

The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample

et al. 2013

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Rationale To improve outcomes for patients undergoing extinction-based therapies (e.g. exposure therapy) for anxiety disorders such as post-traumatic stress disorder, there has been interest in identifying pharmaceutical compounds which might facilitate fear extinction learning and recall. Oxytocin (OT) is a mammalian neuropeptide that modulates activation of fear extinction-based neural circuits and fear responses. Little is known however about the effects of OT treatment on conditioned fear responding and extinction in humans. Objectives The purpose of the present study was to assess the effects of OT in a fear-potentiated startle task of fear conditioning and extinction. Methods A double-blind, placebo-controlled study of 44 healthy human participants was conducted. Participants underwent a conditioned fear acquisition procedure, after which they were randomized to treatment group and delivered OT (24 IU) or placebo via intranasal spray. Forty-five min after treatment, participants underwent extinction training. Twenty-four hrs later subjects were tested for extinction recall. Results Relative to placebo, the OT group showed increased fear potentiated startle responding during the earliest stage of extinction training relative to placebo, however all treatment groups showed the same level of reduced responding by the end of extinction training. Twenty-four hours later the OT group showed significantly higher recall of extinction relative to placebo. Conclusions The current study provides preliminary evidence that OT may facilitate fear extinction recall in humans. These results support further study of OT as a potential adjunctive treatment for extinction-based therapies in fear-related disorders.

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“…In another, INOT improved “mind–reading” (Domes et al, 2007b). A third study found INOT to impair memory for social and non-social visual objects (Herzmann et al, 2012). A fourth study showed that INOT attenuated empathy-related activation within the neural circuitry of pain (Bos et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions

Chen

Gautam

Haroon

et al. 2017

Psychoneuroendocrinology

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The neuropeptide oxytocin (OT) plays a critical role in modulating social behavior across a wide range of vertebrate species. In humans, intranasal oxytocin (INOT) has been shown to modulate various aspects of social behavior, such as empathy, trust, in-group preference, and memory of socially relevant cues. Most INOT studies employ cross-sectional designs despite the enhanced statistical power and reduction in error variance associated with individual differences characteristic of within-subject designs. Using the Prisoner Dilemma task, which models a real-life dyadic social interaction, our group has systematically explored the effect of INOT on social cooperation and non-cooperation using a cross-sectional design. In the current study, we investigated if the main findings from our cross-sectional study could be replicated in a within-subject design using the same paradigm and whether new findings would emerge. We found OT to attenuate the ventral tegmental area response to reciprocated cooperation in women, an effect that is also present in our cross-sectional sample. However, other cross-sectional findings, especially those found in men, were not observed in this within-subject study. We hypothesize that the discrepancy can be explained by differing OT effects based on the degree of stimulus novelty/familiarity. Our within-subject study also revealed new effects not found previously in our cross-sectional study. Most importantly, OT treatment on scan 2 blocked amygdala habituation to unreciprocated cooperation found in a group that received placebo on both scans among men. Our results suggest that exogenous OT reduces the salience of positive social interactions among women and prevents habituation to negative social interactions among men. These findings may have implications for the potential clinical utility of OT as a treatment for psychiatric disorders.

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Oxytocin can impair memory for social and non-social visual objects: A within-subject investigation of oxytocin's effects on human memory

Cited by 44 publications

References 51 publications

Oxytocin eliminates the own-race bias in face recognition memory

Oxytocin eliminates the own-race bias in face recognition memory

The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample

Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions

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