2010
DOI: 10.1038/npp.2010.123
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Abstract: Patients with generalized social anxiety disorder (GSAD) exhibit heightened activation of the amygdala in response to social cues conveying threat (eg, fearful/angry faces). The neuropeptide oxytocin (OXT) decreases anxiety and stress, facilitates social encounters, and attenuates amygdala reactivity to threatening faces in healthy subjects. The goal of this study was to examine the effects of OXT on fear-related amygdala reactivity in GSAD and matched healthy control (CON) subjects. In a functional magnetic r… Show more

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Cited by 433 publications
(334 citation statements)
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“…Notably, OT administration dampened left amygdala reactivity toward all emotional faces in PTSD patients, independent of stimulus valence and participants' sex. This finding corresponds with previous intranasal OT administration studies in healthy individuals (Kirsch et al, 2005) and psychiatric patients with GSAD and BPD (Bertsch et al, 2013;Labuschagne et al, 2010). Our findings extend accumulating evidence that OT may have anxiolytic properties, possibly by inhibiting fear-associated output of the central amygdala to the brainstem and hypothalamus (Huber et al, 2005).…”
Section: Discussionsupporting
confidence: 91%
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“…Notably, OT administration dampened left amygdala reactivity toward all emotional faces in PTSD patients, independent of stimulus valence and participants' sex. This finding corresponds with previous intranasal OT administration studies in healthy individuals (Kirsch et al, 2005) and psychiatric patients with GSAD and BPD (Bertsch et al, 2013;Labuschagne et al, 2010). Our findings extend accumulating evidence that OT may have anxiolytic properties, possibly by inhibiting fear-associated output of the central amygdala to the brainstem and hypothalamus (Huber et al, 2005).…”
Section: Discussionsupporting
confidence: 91%
“…An anatomical scan was first acquired, followed by an emotional face-matching task, which began on average 44.68 (±3.74) minutes after intranasal spray application. This is in line with previous intranasal fMRI studies (Kirsch et al, 2005;Labuschagne et al, 2010), and coincides with the pharmacodynamic peak response of intranasal OT in healthy individuals (Paloyelis et al, 2014).…”
Section: Methodssupporting
confidence: 92%
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