Oxytocin antiserum delays onset of ovarian steroid-induced maternal behavior

Pedersen, Cort A.; Caldwell, Jack D.; Johnson, Michael F.; Fort, S.; Prange, Arthur J.

doi:10.1016/0143-4179(85)90108-8

Cited by 135 publications

(61 citation statements)

References 13 publications

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“…Because estrogen receptors are not colocalized with oxytocin immunoreactivity with the MPOA (Cruttwell et al, 1995), the estrogenic regulation of oxytocin activity is likely trans-synaptic. Nevertheless, infusion of an oxytocin antisera or receptor antagonism blocks the effect of estrogen on maternal behavior (Fahrbach et al, 1985;Pedersen et al 1985). High-LG females show increased estrogen receptor ␣ expression and higher levels of oxytocin receptor binding in the MPOA by comparison with low-LG dams Champagne et al, 2001Champagne et al, , 2003b and intracerebroventricular infusion of a selective oxytocin receptor antagonist reduces LG in high-LG dams to levels comparable with those of low-LG dams.…”

Section: Discussionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

329

257

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Section: Discussionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

329

257

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“…Oxytocin is an important neuroendocrine system implicated in normal maternal behavior onset in rats (Fuchs, 1983;Pedersen et al, 1982;Pedersen, Caldwell, Johnson, Fort, & Prange, 1985;Pedersen et al, 1994) and therefore likely to be implicated when this behavior is disrupted (Pedersen et al, 1985; Van Leengoed, Kerker, & Swanson, 1987). One study looking at rodent maternal behavior suggested that differences in oxytocin levels in brain regions implicated in maternal behavior may be affected intergenerationally (Pedersen & Boccia, 2002).…”

Section: Introductionmentioning

confidence: 99%

Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats.

Johns¹,

Elliott²,

Hofler³

et al. 2005

Behavioral Neuroscience

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The link between impaired maternal behavior (MB) and cocaine treatment could result from druginduced decreases in maternal reactivity to offspring, prenatal drug exposure (PDE) in offspring that could alter their ability to elicit MB, or the interaction of both, which could subsequently impair MB of the 1st-generation dams. Following chronic or intermittent cocaine or saline treatment during gestation, rat dams rearing natural or cross-fostered litters were compared along with untreated dams for MB. Untreated 1st-generation females with differentially treated rearing dams and PDE were tested for MB with their natural litters. The authors report disruptions in MB in dams and their 1st-generation offspring, attributable to main and interaction effects of maternal treatment, litter PDE, and rearing experience. Pregnant women who use cocaine perpetrate child abuse and neglect more often than women who do not use cocaine during pregnancy (Hawley, Halle, Drasin, & Thomas, 1995; Tyler, Howard, Espinosa, & Doakes, 1997; Wasserman & Leventhal, 1993). Maternal cocaine abuse during pregnancy has also been strongly associated with deficits in maternalinfant bonding (Burns, Chethik, Burns, & Clark, 1991), and mothers with a history of substance abuse often exhibit poor mother-infant interactions (Bauman & Dougherty, 1983;Bays, 1990; Howard, Beck-with, Espinosa, & Tyler, 1995;Johnson & Rosen, 1990). Though studies with human participants are helpful in understanding the connection between cocaine use and maternal neglect, these experiments are correlational. There is a necessary lack of control over many important variables that could confound the results, such as socioeconomic issues, lack of family support, multidrug abuse, and poor general prenatal care (Chasnoff et al., 1998;Koren et al., 1998). Studies that use numerous controls have shown a strong correlation between reported history of child maltreatment and the perpetration of maltreatment and/or neglect in next-generation mothers (Egeland, Jacobvitz, & Papatola, 1987;Hunter, Kilstrom, Kraybill, & Loda, 1978).In order to appropriately investigate and describe the characteristics of cocaine-induced disruption of maternal behavior and potential neglect, as well as possible intergenerational effects of such disruptions, a nonhuman cocaine abuse model offers several advantages. The laboratory rat is a particularly good model for the study of maternal behavior. Their offspring are born blind, unable to thermoregulate, defecate, urinate, or protect themselves from attack (Numan, 1994), thus needing considerable maternal care to survive (Stern, 1997). Behaviorally and neurologically, maternal behavior in the rat has also been relatively well characterized (Numan, 1994;Pedersen, Ascher, Monroe, & Prange, 1982;Pedersen, Caldwell, Walker, Ayers, & Mason, 1994) so that any insult to normal maternal behavior can be easily determined.Maternal separation studies also support a rat intergenerational model of behavior showing that cross-fostering results in behavior of offsp...

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“…infusions of oxytocin antagonists or antiserum block or delay the onset of maternal behavior of parturient rats. [4][5][6] It has also been shown that oxytocin infused into the central nucleus of the amygdala of hamsters markedly increases postpartum aggression. 7 All of these reports support the hypothesis that the onset of maternal behavior, and subsequently maternal aggression, is at least partially regulated by oxytocin.…”

Section: Introductionmentioning

confidence: 99%

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

et al. 1997

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SummaryWe examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of delivery (PPD 1), but had no significant effect on the other brain areas. Oxytocin was significantly reduced in the HIP and VTA but not in the AMY or MPOA on PPD 2. These data provide the first evidence for the reduction of oxytocin levels in the VTA, HIP and MPOA as a result of gestational cocaine treatment.

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Oxytocin antiserum delays onset of ovarian steroid-induced maternal behavior

Cited by 135 publications

References 13 publications

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats.

Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

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