Oxytocin and vasopressin in the medial amygdala differentially modulate approach and avoidance behavior toward illness-related social odor

Arakawa, Hiroyuki; Arakawa, Keiko; Deak, Terrence

doi:10.1016/j.neuroscience.2010.10.013

Cited by 106 publications

(84 citation statements)

References 66 publications

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“…Conspecific olfactory cues are processed through main and accessory olfactory bulbs then directly and indirectly to the medial amygdala [63,64]. OT synthesis in the medial amygdala plays a significant role in the reception of social odorant cues and the expression of approach behavior to social stimuli [65,66]. This is consonant with the present result that an OT antagonist blocks reception of OTassociated odorant cues that reduces or suppresses scent marking in odor recipients.…”

Section: Oxytocin Effect On Scent Marking Behaviorsupporting

confidence: 82%

Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

Arakawa

Blanchard

2015

Physiology & Behavior

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Section: Oxytocin Effect On Scent Marking Behaviorsupporting

confidence: 82%

Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

Arakawa

Blanchard

2015

Physiology & Behavior

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“…Within the central amygdala, OT exerts anxiolytic effects and regulates social interactions after stress (Bale et al, 2001;Lee et al, 2007;Neumann, 2002). Moreover, the medial amygdala is prominent for its OTdependent role in social recognition (Choleris et al, 2007;Ferguson et al, 2001) and social odor approach (Arakawa et al, 2010), and OT receptors were described in relatively high density in the central, but also the medial, and basolateral amygdala Tribollet et al, 1988). Additionally, within the central amygdala, increased OT release has been demonstrated during social stimuli, that is, during mother-offspring interactions (Bosch et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

Lukas

Toth

Reber

et al. 2011

Neuropsychopharmacol

347

260

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Social avoidance and social phobia are core symptoms of various psychopathologies but their underlying etiology remains poorly understood. Therefore, this study aims to reveal pro-social effects of the neuropeptide oxytocin (OT), under both basal and stressinduced social avoidance conditions in rodents using a social preference paradigm. We initially show that intracerebroventricular (i.c.v.) application of an OT receptor antagonist (OTR-A) in naïve male rats (0.75 mg/5 ml), or mice (20 mg/2 ml), reduced social exploration of a novel con-specific indicative of attenuated social preference. Previous exposure of male rats to a single social defeat resulted in loss of their social preference and social avoidance, which could be restored by i.c.v. infusion of synthetic OT (0.1 mg/5 ml) 20 min before the social preference test. Although the amygdala has been implicated in both social and OT-mediated actions, bilateral OTR-A (0.1 mg/1 ml) or OT (0.01 mg/1 ml) administration into various subnuclei of the amygdala did not affect basal or stress-induced social preference behavior, respectively. Finally, we demonstrate the social specificity of these OT-mediated effects by showing that neither an arginine vasopressin V1a receptor antagonist (0.75 mg/5 ml, i.c.v.) nor the anxiogenic drug pentylenetetrazol (15 mg/kg, i.p.) altered social preference, with OTR-A not affecting non-social anxiety on the elevated plus-maze. Overall, the data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.

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“…Furthermore, Arakawa and colleagues (2010) found that OT modulates social approach behaviors, via odor communication. Specifically, infusion of OT receptor antagonists into the medial amygdala of male rats inhibited approach behavior (sniffing) toward odor cues from healthy rats (placed in a wiremesh basket) (Arakawa et al, 2010).…”

Section: Ot In Animal Social Behaviormentioning

confidence: 99%

A general approach-avoidance hypothesis of Oxytocin: Accounting for social and non-social effects of oxytocin

Harari-Dahan

Bernstein

2014

Neuroscience & Biobehavioral Reviews

116

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Oxytocin and vasopressin in the medial amygdala differentially modulate approach and avoidance behavior toward illness-related social odor

Cited by 106 publications

References 66 publications

Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

A general approach-avoidance hypothesis of Oxytocin: Accounting for social and non-social effects of oxytocin

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