Oxytocin and Vasopressin: Genetics and Behavioral Implications

Caldwell, Heather K.

doi:10.1007/0-387-30395-2_25

Cited by 25 publications

(41 citation statements)

References 365 publications

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“…Ishizaki et al [11] reported that intracerebroventricular (icv) and intravenous (iv) injection of ghrelin increased plasma arginine vasopressin (AVP) levels in conscious rats. AVP is well known as an important hormone involved in body fluid balance [12]. Thus, it is possible that ghrelin may have a potent effect on drinking behavior and body fluid balance in mammals.…”

Section: Introductionmentioning

confidence: 99%

Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats

et al. 2009

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Ghrelin is a potent, centrally acting orexigenic hormone. Recently, we showed that centrally administered ghrelin is a potent antidipsogenic hormone in 24-h water deprived rats. In this study, we examined the effect of intracerebroventricular (icv) injection of ghrelin on angiotensin II (AII)-induced water intake in rats. We also examined the effects of icv injection of ghrelin on drinking induced by intraperitoneal injection of an isotonic polyethylene glycol (PEG) solution that causes isotonic hypovolemia. Water intake induced by the icv injection of AII or ip injection of PEG was significantly reduced after icv injection of ghrelin, although food intake was stimulated by the hormone. The drinking induced by AII was also inhibited by the icv administration of 4alpha-phorbol 12, 13-didecanoate, an agonist of the osmosensitive TRPV4 channel. This study showed that ghrelin is a potent antidipsogenic peptide by antagonizing general dipsogenic mechanisms including those activated by AII and hypovolemia in rats.

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Section: Introductionmentioning

confidence: 99%

Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats

et al. 2009

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Section: Introductionmentioning

confidence: 99%

“…OT is an acknowledged hormone for uterine contractions during labor and for milk ejection during lactation in mammals [1][2][3][4]. The hormone synthesized in magnocellular neurons is secreted into capillaries in the posterior lobe of the pituitary, whereas the hormone synthesized in parvocellular neurons is transported to various areas of the brain in addition to the pituitary [1]. The OT receptor (OTR), a member of the G protein-coupled receptor family, is expressed widely in the central nervous system (CNS), especially in the ventromedial nucleus of the hypothalamus, the central nucleus of the amygdala, the head of the caudate-putamen and the hippocampus [2,5].…”

Section: Introductionmentioning

confidence: 99%

“…The OT receptor (OTR), a member of the G protein-coupled receptor family, is expressed widely in the central nervous system (CNS), especially in the ventromedial nucleus of the hypothalamus, the central nucleus of the amygdala, the head of the caudate-putamen and the hippocampus [2,5]. Therefore, OT acts as a neurotransmitter/neuromodulator to regulate a range of CNS functions in males and females, including emotional [6,7], parental [8][9][10], affiliative [11,12], and sexual [2] behaviors, as well as spatial and social memories [1,5].…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin: a therapeutic target for mental disorders

et al. 2012

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We review here that oxytocin (OT) is released into blood and within distinct brain regions in response to stressful and social stimuli, and has been shown to have an antidepressant-like effect in animal studies. Clinical reports suggest OT to be a promising drug for psychiatric diseases such as depression, anxiety disorders, schizophrenia, and autism. OT may also have therapeutic potential in the treatment of major depressive disorders, even though OT administered into blood does not readily cross the blood-brain barrier. Physiological functions such as sexual activity and mating induce the release of OT in the central nervous system. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. This drug has antidepressant-like effects through activation of an OT signaling pathway. These results suggest that sildenafil may have promise as a potential antidepressant.

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“…As it is well known, oxytocin (OXT) and arginine-vasopressin (AVP) strongly affect human behavior and physiology [1]. There is a close structure homology between these two nonapeptides which both contain a disulphide bridge and differ at only two amino acid positions.…”

Section: Introductionmentioning

confidence: 99%