Oxytocin and serotonin make it worthwhile

Flight, Monica Hoyos

doi:10.1038/nrn3610

Cited by 3 publications

(3 citation statements)

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“…These neurons seem to promote avoidance behavior at high-salt concentrations, and one model proposes that CTA increases their sensitivity to lower salt concentrations (Hukema et al, 2006) and that this requires nematocin signaling (Beets et al, 2013). Interestingly, nematocin signaling interacts with serotonergic and dopaminergic neurotransmission, two signaling pathways that are also affected by AVP and OT in vertebrates, especially mammals (Dö len and Malenka, 2014;Flight, 2013;Insel, 2010;Love, 2014;Morrison and Melloni, 2014). In rodents, CTA has been linked to synaptic plasticity in the amygdala, and in mice OT has indeed been found to affect acquisition of CTA (Olszewski et al, 2013).…”

Section: Ot and Gustatory Systemmentioning

confidence: 99%

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

Grinevich

Stoop

2018

Neuron

115

108

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The neuropeptide oxytocin (OT) attracts the interest of neuroscientists, psychologists, and psychiatrists due to its capacity to modulate emotional and social behavior. Although much has been published on the effects of OT on brain regions and mechanisms at the core of these processes, its role in sensory processing, so important for detecting social context with sufficient accuracy and sensitivity, has been much less studied. In the present review, we summarize evidence for OT modulation of sensory processing and, conversely, effects of sensory input on endogenous OT signaling. We concentrate on mammals, aiming to provide a systematic analysis of the current knowledge on this reciprocal regulation and the role it may play in social and emotional behaviors.

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Section: Ot and Gustatory Systemmentioning

confidence: 99%

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

Grinevich

Stoop

2018

Neuron

115

108

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“…Further experimentation with tryptophan loading protocols (Murphy et al 2006, 2009), single or sub-chronic treatments with anti-depressants could indicate whether the accuracy of Neuroticism inferences from the face can be improved by enhancing serotonergic activity and other personality inferences in treated and untreated depressed patients. Similarly, trait inferences about potential social partners may regulate approach and withdrawal behaviours, highlighting the issue of how serotonergic modulation of these judgements relates to the activity of the inter-dependent peptide systems implicated in both mood and social bonding, such as oxytocin (Dolen 2015; Flight 2013). …”

Section: Discussionmentioning

confidence: 99%

The role of serotonin in personality inference: tryptophan depletion impairs the identification of neuroticism in the face

et al. 2017

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Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signals. Faces with neutral expressions signal a variety of socially relevant information, such that inferences about the big five personality traits, including Neuroticism, Extraversion and Agreeableness, can be accurately made on the basis of emotionally neutral facial photographs. Given the close link between Neuroticism and psychological distress, we investigated the effects of diminished central serotonin activity (achieved by tryptophan depletion) upon the accuracy of 52 healthy (non-clinical) adults’ discriminations of personality from facial characteristics. All participants were able to discriminate reliably four of the big five traits. However, the tryptophan-depleted participants were specifically less accurate in discriminating Neuroticism than the matched non-depleted participants. These data suggest that central serotonin activity modulates the identification of not only negative facial emotional expression but also a broader class of signals about personality characteristics linked to psychological distress.

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“…Oxytocin is a nonapeptide hormone that acts as an endocrine chemical messenger, playing roles in numerous functions, including parturition, lactation, pair-bonding, maternal care, sexual behavior, social attachment, and the relief of fear and anxiety . In the mammalian brain, oxytocin is synthesized mainly in the hypothalamic periventricular nucleus (PVN) and the magnocellular hypothalamic supraoptic nucleus (SON). ,− Oxytocin influences the release of multiple neurotransmitters, including dopamine, serotonin, and GABA through its interactions with receptors in several brain regions, including the thalamus, hypothalamus, brainstem, basal ganglia, limbic system, and select cortical areas. , Thus, given its specific functions in regulating neurotransmitter systems, understanding the dynamics of oxytocin release on relevant timescales and with sufficient sensitivity in living brain tissue is a critical need.…”

mentioning

confidence: 99%

Optimized Sawhorse Waveform for the Measurement of Oxytocin Release in Zebrafish

2022

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Oxytocin is a nonapeptide hormone involved in numerous physiological functions. Real-time electrochemical measurements of oxytocin in living tissue are challenging due to electrode fouling and the large potentials needed to oxidize the tyrosine residue. Here, we used fast-scan cyclic voltammetry at carbon-fiber microelectrodes and flow injection analysis to optimize a waveform for the measurement of oxytocin. This optimized waveform employed an accumulation potential of −0.6 V, multiple scan rates, and a 3 ms holding potential at a positive, oxidizing potential of +1.4 V before linearly scanning the potential back to −0.6 V (versus Ag/AgCl). We obtained a limit of quantitation of 0.34 ± 0.02 μM, and our electrodes did not foul upon multiple injections. Moreover, to demonstrate the utility of our method, we measured the release of oxytocin, evoked by light application and mechanical perturbation, in whole brains from genetically engineered adult zebrafish that express channelrhodopsin-2 selectively on oxytocinergic neurons. Collectively, this work expands the toolkit for the measurement of peptides in living tissue preparations.

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Oxytocin and serotonin make it worthwhile

Cited by 3 publications

References 1 publication

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

The role of serotonin in personality inference: tryptophan depletion impairs the identification of neuroticism in the face

Optimized Sawhorse Waveform for the Measurement of Oxytocin Release in Zebrafish

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