Oxytocin and Parental Behaviors

Yoshihara, Chihiro; Numan, Michael; Kuroda, Kumi O.

doi:10.1007/7854_2017_11

Cited by 65 publications

(61 citation statements)

References 145 publications

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“…Oxytocin release regulates parental behaviours, whereas kisspeptins control reproduction . However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin.…”

Section: Discussionmentioning

confidence: 78%

“…Additionally, VGLUT3 antibody labels predominantly synaptic terminals in the hypothalamus, although cell bodies can be observed in the paraventricular nucleus of the hypothalamus (J. Donato, unpublished data) and in the brainstem. 50,51 Oxytocin release regulates parental behaviours, 60 whereas kisspeptins control reproduction. 61 However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin.…”

Section: Discussionmentioning

confidence: 99%

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Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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Neurones expressing the melanin‐concentrating hormone (MCH) can be found in the medial preoptic area (mPOA) and ventral aspects of the periventricular preoptic nucleus of rats by mid‐to‐late lactation and this expression disappears after weaning. The transitory expression of MCH in the preoptic area suggests a role for these neurones in the control of the end of lactation. However, the neurochemical identity of mPOA MCH neurones and the regulatory factors that control the transient MCH expression remain largely unknown, especially in the mouse. In the present study, we showed that mice also present the transitory expression of MCH in the mPOA at late lactation. mPOA MCH cells did not colocalise significantly with markers of GABAergic (VGAT), glutamatergic (VGLUT2 and VGLUT3) or dopaminergic (tyrosine hydroxylase) neurones. mPOA MCH cells also did not express Kiss1 or oxytocin. By contrast, approximately 70% and 90% of mPOA MCH neurones colocalised with oestrogen receptor α and prolactin‐induced phosphorylated signal transducer and activator of transcription 5 (STAT5), respectively. Finally, we demonstrated that the number of MCH neurones in the mPOA is significantly higher in females during the first lactation, compared to mice on the second lactation or pregnant mice during the first lactation or brain‐specific STAT5 knockout mice during the first lactation. In summary, our findings indicate that MCH neurones in the mPOA of lactating mice are sensitive to oestrogens and prolactin. Thus, mPOA MCH expression is possibly influenced by hormonal variations. Furthermore, the STAT5 signalling pathway is likely involved in the regulation of MCH expression in the mPOA of lactating mice.

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“…Oxytocin release regulates parental behaviours, whereas kisspeptins control reproduction . However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin.…”

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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“…Mother–infant interactions are the foundation for organising infant neurobiological, sensory, perceptual, physical, emotional and relational systems . Animal models confirm the developmental relevance of early occurring maternal care via postnatal ‘programming’ of behavioural , cardiovascular , neuroendocrine and epigenetic systems underlying stress responding. Parallel studies also exist in the human literature.…”

Section: Introductionmentioning

confidence: 99%

The Welch Emotional Connection Screen: validation of a brief mother–infant relational health screen

et al. 2018

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“…Oxytocin is a known hormonal mediator of maternal behavior [13] . To examine whether L. lactis exposure during pregnancy may increase maternal oxytocin levels, we measured oxytocin in plasma of treated and control dams 1 day after birth (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Prenatal exposure to the probiotic Lactococcus lactis decreases anxiety-like behavior and modulates cortical cytoarchitecture in a sex specific manner

Surzenko

Pjetri

Munson

et al. 2019

Preprint

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24 Development of the cerebral cortex may be influenced by the composition of the maternal gut 25 microbiota. To test this possibility, we administered probiotic Lactococcus lactis in the drinking 26 water to mouse dams from day 10.5 of gestation and until pups reached postnatal day 1 (P1).27 Pups were assessed in a battery of behavioral tests starting at 10 weeks old. We found that 28 females, but not males, exposed to probiotic during prenatal development spent more time in the 29 center of the open field and also displayed decreased freezing time in cue associated learning, 30 compared to controls. Furthermore, we found that probiotic exposure changes the densities of 31 cortical neurons and increases the density of blood vessels in the cortical plate of P1 pups. Sex-32 specific differences were observed in the numbers of mitotic neural progenitor cells, which were 33 increased in probiotic exposed female pups. In addition, we found that probiotics treatment 34 throughout pregnancy significantly increased plasma oxytocin levels in mouse dams, but not in 35 the offspring. These results suggest that exposure of naïve, unstressed dams to probiotic may 36 exert sex-specific long-term effects on cortical development and anxiety related behavior in the 37 offspring. 38 39 40 41 Introduction 42 Neocortical development is influenced by a variety of environmental factors, including maternal 43 nutrition, stress and exposure to pathogens. In terms of cortical patterning and growth, the impact 3 44 of essential micronutrients, such as choline, has been well-characterized; yet less is known on 45 how food-derived microbiota, e.g. probiotics, may be altering cortical development at different 46 stages [1] . While the fetal gut is sterile before birth, it is increasingly clear that factors from the 47 maternal microbiota can induce specific patterns of gene expression in the fetal gut, as well as in 48 the brain [1][2][3] . After birth, microbial colonization of the infant gastrointestinal tract has been 49 shown to have widespread influence on brain development and behavior [4] . For example, mice 50 whose gut microbiota were depleted via antibiotics or who were raised in a germ-free facility 51 demonstrate exaggerated responses to stress and social stimuli, and display neurochemical and 52 brain structural abnormalities [5, 6] . Recently, neonatal exposure to probiotics, such as Bifidus 53 longum and Lactobacillus rhamnosous, have been shown to reverse maladaptive learning 54 behaviors in innately anxious mice [7] . Probiotics have also alleviated behavioral effects in other 55 models of anxiety disorders, such as those induced by maternal separation, social defeat or other 56 types of early life stress [8][9][10] . Mounting data on brain-gut axis has revealed several pathways 57 where probiotic treatment can affect microbiota populations, brain signaling, and subsequently 58 anxiety in mouse models of disease. However, there is less consensus on the behavioral effects 59 of probiotics in naïve, wild type mice which h...

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Oxytocin and Parental Behaviors

Cited by 65 publications

References 145 publications

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

The Welch Emotional Connection Screen: validation of a brief mother–infant relational health screen

Prenatal exposure to the probiotic Lactococcus lactis decreases anxiety-like behavior and modulates cortical cytoarchitecture in a sex specific manner

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