Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum

Schorr, Melanie; Marengi, Dean A.; Pulumo, Reitumetse; Yu, Elaine W.; Eddy, Kamryn T.; Klibanski, Anne; Miller, Karen K.; Lawson, Elizabeth A.

doi:10.1210/jc.2016-3963

Cited by 51 publications

(53 citation statements)

References 42 publications

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“…Thus, a true comparison between results originating from different investigational procedures seems challenging. It would have been stimulating to test non-extracted oxytocin in our subjects to thoroughly compare our results with findings previously described by others [24]. In a search for potential explanatory mechanisms related to our findings, we noted a robust inverse correlation between oxytocin and leptin levels.…”

Section: Discussionsupporting

confidence: 78%

“…In this regard, we hypothesize that the high BMI values of our obese patients could have yielded a broad bulky effect on oxytocin secretion. To date, oxytocin levels in obesity have been found decreased [18], unchanged [41], or even increased [24] as compared to controls. Several reasons could contribute to explain these discrepancies, such as differences in study cohorts, gender prevalence, degree of obesity, sampling procedures, and analytical methodologies [21,28].…”

Section: Discussionmentioning

confidence: 99%

“…Several reasons could contribute to explain these discrepancies, such as differences in study cohorts, gender prevalence, degree of obesity, sampling procedures, and analytical methodologies [21,28]. In a recent cross-sectional investigation on premenopausal women, mean nocturnal concentrations of non-extracted oxytocin were found to be higher in mildly obese compared to lean eumenorrhoic women [24]. The elaborated sampling procedure associated with this investigation significantly expands current knowledge on premenopausal oxytocin secretion [24].…”

Section: Discussionmentioning

confidence: 99%

“…In a recent cross-sectional investigation on premenopausal women, mean nocturnal concentrations of non-extracted oxytocin were found to be higher in mildly obese compared to lean eumenorrhoic women [24]. The elaborated sampling procedure associated with this investigation significantly expands current knowledge on premenopausal oxytocin secretion [24]. However, it is worth mentioning that obesity alters nocturnal secretory orderliness of feeding-related hormones [42], and mean nighttime levels only partially reflect the nocturnal dynamics of hormone secretion [42,43,44].…”

Section: Discussionmentioning

confidence: 99%

“…In line with these evidences, cohort studies investigating oxytocin concentration additionally found an inverse association between oxytocin and obesity, HbA1C levels, insulin resistance as well as T1DM or T2DM, thus emphasizing the potential negative influence of positive energy states on circulating oxytocin [21,22,23]. However, this inference has been recently challenged in a study in premenopausal women with different energy states [24]. …”

Section: Introductionmentioning

confidence: 97%

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Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

et al. 2018

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Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post- than in premenopausal women (NW: p < 0.05; OB: p < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

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Section: Discussionsupporting

confidence: 78%