Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

Goodin, Burel R.; Ness, Timothy J.; Robbins, Meredith T.

doi:10.2174/1381612820666141027111843

Cited by 58 publications

(47 citation statements)

References 154 publications

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“…given that it stores oxytocin. High doses of radiation may redirect the oxytocin towards the dorsal horns of the spinal cord and supraspinal levels which have clear implications on pain modulation of neuropathic and inflammatory origin [17][18][19], and that could also explain the transitory pain relief effects on non-oncological pain such as thalamic pain and orofacial pain [20].…”

Section: Discussionmentioning

confidence: 99%

Automated Stereotactic Gamma Ray Radiosurgery to the Pituitary Gland in Terminally Ill Cancer Patients with Opioid Refractory Pain

Lovo¹,

Campos²,

Caceros³

et al. 2019

Cureus

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Introduction We report our initial series of terminally ill cancer patients treated with radiosurgery to the pituitary gland to alleviate pain. Methods A fully automated rotating gamma ray unit was used to deliver a high dose of radiation (150Gy) using an 8 mm collimator to the neurohypophysis in 11 patients suffering from opioid-refractory pain deriving from cancer. Results From November 2016 to November 2018, 11 patients were treated, and 10 were eligible for follow-up evaluation. Pain from bone metastases was present in 70%; others suffered from neuropathic and visceral pain. The median survival was 119.7 days (range: 32 to 370). The visual analogue scale (VAS) was nine (7-10) and standardized to 10; eight patients (80%) responded. The average VAS at the time of response was three (range: 1-6), and the average time to response was 2.8 days (range: 2-5). In the first week, 40% of the patients categorized the result as 'excellent', 30% deemed the result 'good', and 20% reported the result as 'poor'. One patient (10%) referred to the result as 'regular'. Those who responded were able to reduce their medications by at least 25%. The one-month average VAS score was five (range: 1-6), 60% reported a 'good' effect, 20% reported 'excellent' results, and 20% had no response. Of the study participants, 60% maintained their level of medicine consumption at lower than baseline. At the end of life, five patients (50%) presented substantial pain, two (20%) never had a therapeutic effect, and three (30%) died without substantial pain. There were no clinical complications that could be attributed directly to the treatment. Conclusion Radiosurgery to the pituitary gland is effective and safe and warrants further investigation to understand its potential role in palliative care in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Automated Stereotactic Gamma Ray Radiosurgery to the Pituitary Gland in Terminally Ill Cancer Patients with Opioid Refractory Pain

Lovo¹,

Campos²,

Caceros³

et al. 2019

Cureus

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“…20 Interestingly, oxytocin, with its regulatory effects on pain, mood, and stress responses, has been postulated as a novel analgesic for chronic pain. 21 Breastfeeding brings well-known positive health benefits to the infant, particularly protection against childhood infections, together with claims of higher intelligence, fewer emotional and behavioral difficulties in later life, and protection against obesity and diabetes, although many of these outcomes are confounded by socioeconomic factors and thus may reflect association rather than causation. 22 Ongoing pain can affect breastfeeding in two ways: women may be reluctant to take analgesia for fear of drug transfer to their baby during breastfeeding leading to poorly managed pain, and abdominal pain from the caesarean scar may compromise positioning, making feeding more difficult.…”

Section: Postnatal Depressionmentioning

confidence: 99%

Caesarean delivery: Bringing more than just a bundle of joy

Quinlan

2019

Canadian Journal of Pain

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Background: Chronic postsurgical pain (CPSP) is a potential complication of all surgical procedures, including caesarean delivery (CD). Psychological factors such as anxiety and depression with negative coping strategies are known to increase the risk of the development of CPSP. Aim: This short review will appraise some additional features that are unique to CD and assess the interplay between them and persisting pain. Methods: This is a narrative review with a focus on describing relevant features associated with the development of CPSP after CD. Results: Hormone changes, postpartum depression, breastfeeding, and sleep disturbance each may affect the mother's pain in the short and long term. Together they have the potential to negatively impact the mother-infant bond. Conclusions: In the weeks after delivery, pain, depression, and poor sleep negatively impact the mother's quality of life and her ability to care for, and bond with, her baby. This represents a critical time for the emotional, social, and behavioral development of the infant. Far-reaching benefits for the whole family may be realized by the early identification and management of persisting postoperative pain and postpartum depression. RÉSUMÉContexte: La douleur chronique postopératoire est une complication possible de toutes les interventions chirurgicales, y compris l'accouchement par césarienne. Il est bien connu que certains facteurs psychologiques comme l'anxiété et la dépression, assortis de stratégies d'adaptation négatives, augmentent le risque de souffrir de douleur chronique postopératoire. But: Ce bref examen porte sur certaines caractéristiques particulières de l'accouchement par césarienne et évalue l'interaction entre celles-ci et la douleur persistante. Méthodes: Un examen narratif mettant l'accent sur la description des caractéristiques pertinentes associées au développement de la douleur chronique post-chirurgicale après un accouchement par césarienne. Résultats: Les changements hormonaux, la dépression postpartum, l'allaitement et les perturbations du sommeil peuvent tous affecter la douleur de la mère à court terme et à long terme. Ensemble, ils peuvent avoir un effet négatif sur le lien entre la mère et le nourrisson. Conclusions: Dans les semaines suivant l'accouchement, la douleur, la dépression et les problèmes de sommeil peuvent avoir des répercussions négatives sur la qualité de vie de la mère, ainsi que sur sa capacité à s'occuper de son bébé et à créer un lien avec lui. Il s'agit d'un moment de première importance pour le développement émotionnel, social et comportemental de l'enfant. La détection précoce et la prise en charge de la douleur postopératoire persistante ainsi que de la dépression postpartum peuvent avoir des bienfaits de grande portée pour toute la famille. ARTICLE HISTORY

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“…Additionally, it is considered that OT may interact with the central endogenous opioid system and therefore, produce analgesia and nociceptive effects [1]. There are few studies that evidence the role of OT in pain perception through somatosensory transmission, they suggest that low endogenous OT levels are associated to chronic pain conditions and increased pain sensitivity [2].…”

Section: Oxytocin; Analgesiamentioning

confidence: 99%

Oxytocin: A New Painkiller?

Tay¹,

Yamamoto²

2016

J Pain Relief

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Oxytocin is a peptide hormone released in our body. It plays a very well-known role in pregnancy-related uterine contractions and lactation. But oxytocin does a lot more than just helping women get through labour. Recent studies have shown that it contributes to pain perception and pain physiology. In this short article, we emphasize the potential role it has on pain relief and our aim is to promote the increase of researches about the subject.

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Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

Cited by 58 publications

References 154 publications

Automated Stereotactic Gamma Ray Radiosurgery to the Pituitary Gland in Terminally Ill Cancer Patients with Opioid Refractory Pain

Automated Stereotactic Gamma Ray Radiosurgery to the Pituitary Gland in Terminally Ill Cancer Patients with Opioid Refractory Pain

Caesarean delivery: Bringing more than just a bundle of joy

Oxytocin: A New Painkiller?

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