Oxytetracycline residue levels in chicken eggs after oral administration of medicated drinking water to laying chickens

Omija, B; Mitema, Eric S.; Maitho, Timothy

doi:10.1080/02652039409374265

Cited by 23 publications

(13 citation statements)

References 8 publications

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“…Some studies had induced pharmacokinetic data in poultry [14]- [19]. Tylosin was obeyed a two compartments open model following I.V.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with Vd(area) of 6 L/kg and eliminated with half-life (t1/2β) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (Cmax) was 3.40 µg/ml attained at (tmax) of 1.08 hour. Tylosin was eliminated with half-life (t1/2β) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (µg/ml) and tissue (µg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.

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“…Some studies had induced pharmacokinetic data in poultry [14]- [19]. Tylosin was obeyed a two compartments open model following I.V.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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“…Residues appear more rapidly in egg albumen than yolk following drug administration, but concentrations reach higher levels and persist longer in egg yolk (Yoshida et al ., 1973c; Roudaut et al. , 1989; Omija et al. , 1994; Zurhelle et al.…”

Section: Overview Of the Drug Classesmentioning

confidence: 99%

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Goetting¹,

Lee²,

Tell³

2011

Journal of Veterinary Pharmacology and Therapeutics

148

135

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Goetting, V., Lee, K. A., Tell, L. A. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J. vet. Pharmacol. Therap.34, 521–556. Poultry treated with pharmaceutical products can produce eggs contaminated with drug residues. Such residues could pose a risk to consumer health. The following is a review of the information available in the literature regarding drug pharmacokinetics in laying hens, and the deposition of drugs into eggs of poultry species, primarily chickens. The available data suggest that, when administered to laying hens, a wide variety of drugs leave detectable residues in eggs laid days to weeks after the cessation of treatment.

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“…Egypt had no especial TCs regulation, but it considers the MRLs of the Codex Alimentarius Commission. However, the level of TCs above the MRL have been reported in chicken products in many countries such as Mexico (Vazquez-Moreno et al 1990), Kenya (Omija et al 1994), Belgium (De Wasch et al 1998), Saudi Arabia (Al-Ghamdi et al 1999, Iran (Salehzadeh et al 2006), Pakistan (Shahid et al 2007) and Bulgaria (Pavlov et al 2008).…”

Section: Introductionmentioning

confidence: 95%

Incidence of tetracycline residues in chicken meat and liver retailed to consumers

Salama

Abou-Raya

Shalaby

et al. 2011

Food Additives and Contaminants: Part B

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The incidence of tetracyclines' (TCs) residue (oxytetracycline, tetracycline, chlorotetracycline and doxycycline) in fresh chicken samples (meat and liver) collected during one year was recorded. TC residues were analysed using an HPLC-DAD method. The limit of detection for meat was 4.4, 5, 10 and 7 ng g(-1) for OTC, TTC, CTC and DOC, respectively, compared with 5.5, 6, 12 and 9 ng g(-1) stated for liver. The recovery of the method ranged from 91% to 70% depending upon both matrix type and tetracycline kind. The results revealed that 66 (44%) samples contained TC residues including 21 (42%) breast, 19 (38%) thigh and 26 (52%) liver samples. The corresponding contaminated ranges were 124-5812, 107-6010 and 103-8148 µg kg(-1). A total of 12 (8%), 13 (7.33%) and 20 (13.33%) samples of breast, thigh and liver, respectively, had TC residues above the Codex maximum residue limit (MRL). Liver samples had a higher incidence and level than those found in breast or thigh samples.

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Oxytetracycline residue levels in chicken eggs after oral administration of medicated drinking water to laying chickens

Cited by 23 publications

References 8 publications

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Incidence of tetracycline residues in chicken meat and liver retailed to consumers

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