1982
DOI: 10.1136/bjo.66.6.386
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Oxytetracycline in the treatment of ocular rosacea: a double-blind trial.

Abstract: Rosacea is a common condition affecting the skin of the face, with less frequent involvement of the eyes. Nonspecific ocular complications are similar to those found in patients with seborrhoea, blepharitis, recurrent chalazia, styes and trichiasis, hyperaemic conjunctivitis, with occasional marginal corneal infiltrates or ulcers. Specific complications include nodular conjunctivitis and episcleritis, which are rare, and the typical progressive keratitis which occurs in 5% of patients with rosacea.I Oxytetracy… Show more

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Cited by 42 publications
(20 citation statements)
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“…In a double-blind, placebo-controlled trial, 35 patients with ocular rosacea who received 250 mg of oxytetracycline twice daily for six weeks had a significantly higher rate of remission than did patients who received a placebo (65 percent vs. 28 percent). 49 In an uncontrolled study of 39 patients with cutaneous rosacea (28 with ocular symptoms), 100 mg of doxycycline daily for 12 weeks improved symptoms of dryness, itching, blurred vision, and photosensitivity. 50 After ocular symptoms subside, the maintenance of lid hygene and the use of artificial tears are usually recommended.…”
Section: Subtypementioning
confidence: 99%
“…In a double-blind, placebo-controlled trial, 35 patients with ocular rosacea who received 250 mg of oxytetracycline twice daily for six weeks had a significantly higher rate of remission than did patients who received a placebo (65 percent vs. 28 percent). 49 In an uncontrolled study of 39 patients with cutaneous rosacea (28 with ocular symptoms), 100 mg of doxycycline daily for 12 weeks improved symptoms of dryness, itching, blurred vision, and photosensitivity. 50 After ocular symptoms subside, the maintenance of lid hygene and the use of artificial tears are usually recommended.…”
Section: Subtypementioning
confidence: 99%
“…The treatments could be categorized into 5 groups: topical metronidazole (15 trials), [21][22][23]27,29,30,32,33,36,38,39,42,43,48,50 oral antibiotics (8 trials), 23,26,28,40,44,45,47,50 topical azelaic acid (6 trials), 22,31,35,36,49 topical benzoyl peroxide combined with topical antibiotics (2 trials), 34,43 and other therapies (4 trials). 37,41,44,46 Five trials included comparisons in more than one category.…”
Section: Description Of Studies and Methodologic Quality Of Included mentioning
confidence: 99%
“…27,43 Intention-to-treat analysis was used in 17 of the 29 trials. [21][22][23]26,[28][29][30][31][32][34][35][36][37][38][39]49 For 14 studies the variability (SD or SE) of continuous measurements were completely or partially lacking, making these data unusable in a metaanalysis. 21,30,[32][33][34][36][37][38][41][42][43]46,48,50 Analysis…”
Section: Description Of Studies and Methodologic Quality Of Included mentioning
confidence: 99%
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