Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama

Cardoso-Martínez, Faviola; Rosa, José M. de la; Dárias, José; D’Croz, Luis; Jiménez-Antón, María Dolores; Corral, María Jesús; García, Rocío; Alunda, José María; Cueto, Mercedes

doi:10.1039/c6ra04521a

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…[ 84 ]; a new oxysterol ( 91 ), isolated from a Panamanian octocoral Gorgonia sp. that moderately reduced the multiplication of L. infantum promastigotes thus suggesting “antileishmanial efficacy against intracellular amastigotes” [ 91 ]; two linear furanosesterterpenoids ircinin-1 and -2 ( 92 , 93 ) from the Turkish sponge Ircinia oros with moderate activity against L. donovani , suggesting the compounds’ “bifuran terminus… positively influences the in vitro antiprotozoal activity” [ 92 ]; a new cyclic polyketide-peptide hybrid janadolide ( 94 ) from the Japanese marine cyanobaterium Okeania sp. which demonstrated very potent activity against T. brucei brucei, thus revealing potential for development as “new antitrypanosomal drugs” [ 93 ]; the cyclic pentapeptide malformin A1 ( 95 ) isolated from the Philippine marine seagrass-derived fungus Aspergillus tubingensis IFM 63452 highly active towards the parasite T. congolense and recommended as ”an antiprotozoal agent” [ 94 ]; a novel azepino-diindole alkaloid rhodozepinone ( 96 ) isolated from a Red Sea marine sponge-derived bacterium Rhodococcus sp.…”

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

“…[84]; a new oxysterol (91), isolated from a Panamanian octocoral Gorgonia sp. that moderately reduced the multiplication of L. infantum promastigotes thus suggesting "antileishmanial efficacy against intracellular amastigotes" [91]; two linear furanosesterterpenoids ircinin-1 and -2 (92, 93) from the Turkish sponge Ircinia oros with moderate activity against L. donovani, suggesting the compounds' "bifuran terminus . .…”

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

“…Niger fatty acids ( 89 , 90 )/sponge Lipid e L. infantum inhibition 0.17, 0.34 mg/mL TopIB inhibition ESP, USA [ 90 ] Antileishmanial dudawalamide D ( 82 )/cyanobacterium Peptide f L. donovani inhibition 2.6 μM Undetermined JOR, PAN, USA [ 84 ] Antileishmanial Gorgonia sp. sterol ( 91 ) sponge Terpenoid e L. infantum inhibition >10 μM * Undetermined ESP, PAN [ 91 ] Antileishmanial ircinin-1 and 2 ( 92 , 93 )/sponge Terpenoid e L. donovani inhibition 28–31 μM Undetermined CHE, DEU, ITA, TUR [ 92 ] Antitrypanosomal janadolide ( 94 )/cyanobacterium Peptide f T. b. brucei inhibition 0.047 μM Undetermined JPN [ …”

Section: Introductionmentioning

confidence: 99%

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Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

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The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

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Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

Section: Antiprotozoal and Antituberculosis Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

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“…Steroid named crassarosteroside A (104) was obtained from Sinularia granosa and S. crassa soft coral extracts [251,252], compound 105 has been isolated from Sinularia conferta and S. nanolobata [253,254], and metabolite 106 was detected in MeOH extract of the soft coral S. cruciata [255]. Oxysterol (107) was detected in extracts of octocoral of the genus Gorgonia from the eastern Pacific, Panama [256].…”

Section: Miscellaneous Steroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

Dembitsky

2021

Marine Drugs

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This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid phosphate esters, highly oxygenated steroids such as steroid endoperoxides and hydroperoxides, α,β-epoxy steroids, and secosteroids. In addition, subgroups of carbon-bridged steroids, neo steroids, miscellaneous steroids, as well as synthetic steroids containing heteroatoms S (epithio steroids), Se (selena steroids), Te (tellura steroids), and At (astatosteroids) were presented. Natural steroids and triterpenoids have been found and identified from various sources such as marine sponges, soft corals, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in fungi, fungal endophytes, and plants. The pharmacological profile of the presented steroids and triterpenoids was determined using the well-known computer program PASS, which is currently available online for all interested scientists and pharmacologists and is currently used by research teams from more than 130 countries of the world. Our attention has been focused on the biological activities of steroids and triterpenoids associated with the regulation of cholesterol metabolism and related processes such as anti-hyperlipoproteinemic activity, as well as the treatment of atherosclerosis, lipoprotein disorders, or inhibitors of cholesterol synthesis. In addition, individual steroids and triterpenoids were identified that demonstrated rare or unique biological activities such as treating neurodegenerative diseases, Alzheimer’s, and Parkinson’s diseases with a high degree of certainty over 95 percent. For individual steroids or triterpenoids or a group of compounds, 3D drawings of their predicted biological activities are presented.

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“…austera [159]. Oxysterols (176)(177)(178)(179)(180)(181) were detected and identified from an octocoral of the genus Gorgonia from the eastern Pacific of Panama [160]. The structures of the steroids (178)(179)(180)(181)(182)(183)(184)(185)(186)(187) are shown in Figure 9 and the potential biological activities are shown in Table 10.…”

Section: Steroids Derived From the Other Coral's Generamentioning

confidence: 99%

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

et al. 2020

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The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated steroids and steroids containing sulfur or nitrogen heteroatoms. Of greatest interest is the pharmacological activity of these steroids. More than 40 steroids exhibit antitumor and related activity with a confidence level of over 90 percent. A group of 32 steroids shows anti-hypercholesterolemic activity with over 90 percent confidence. Ten steroids exhibit anti-inflammatory activity and 20 steroids can be classified as respiratory analeptic drugs. Several steroids exhibit rather rare and very specific activities. Steroids exhibit anti-osteoporotic properties and can be used to treat osteoporosis, as well as have strong anti-eczemic and anti-psoriatic properties and antispasmodic properties. Thus, this review is probably the first and exclusive to present the known as well as the potential pharmacological activities of 200 marine steroids.

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Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama

Abstract: Eighteen new oxysterols were isolated from a previously undescribed octocoral of the genusGorgonia. Antimicrobial and antileishmanial properties of these compounds have been evaluated.

Cited by 9 publications

References 25 publications

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

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