Oxysterol metabolism dictates macrophage influx during SARS-CoV-2 infection

Abstract

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Exploring the Activation Mechanism of the GPR183 Receptor

“…Furthermore, GPR183 receptor ligands have exhibited direct antiviral properties and have been reported in the context of SARS-CoV-2 infection . Inflammatory responses in the lung driven by oxysterols via GPR183 have also been demonstrated, supporting the therapeutic potential of targeting GPR183 during severe viral respiratory infections. , Moreover, GPR183 plays a cell-intrinsic role in the organization and survival of hepatic dendritic cells in the liver, making it a potential therapeutic target for liver diseases . Overall, these findings underscore the significant therapeutic potential of the GPR183 receptor.…”