Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia

Andrabi, Shaida A.; Spina, Mariarosa; Lorenz, Peter; Ebmeyer, Uwe; Wolf, Gerald; Horn, Thomas F.W.

doi:10.1016/j.brainres.2004.05.038

Cited by 120 publications

(99 citation statements)

References 49 publications

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“…These results indicate that KRG, which is a potent antioxidant, prevents the neurobehavioral deficits in the animals by scavenging free radicals. Several authors have also reported that certain antioxidants, including oxyresveratrol and rutin, promote the improvement of neurological deficits by diminishing the level of oxidative stress (35,36). Moreover, it has been reported that glutathione depletion in the rat brain affects neurobehavioral activity (37), indicating a correlation between oxidative stress and behavioral impairment following MCAO injury.…”

Section: Discussionmentioning

confidence: 99%

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

Ban

Kang

Lee

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. In the present study, we investigated the neuroprotective effect of Korean red ginseng (KRG) following focal brain ischemia/reperfusion injury, in relation to its antioxidant activities. The middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats was employed. The KRG extract (100 mg/kg, perorally) was administered once daily for 7 days following MCAO/R. The elevated levels of lipid peroxidation in the MCAO/R group were attenuated significantly in the KRG-administered group. The significantly depleted activity of the antioxidant enzymes glutathione peroxidase, superoxide dismutase and catalase was prevented in the KRG-administered group. In the neurobehavioral evaluation expressed as the modified neurological severity score and corner-turn test, the daily intake of KRG showed consistent and significant improvement in the neurological deficits for 7 days following MCAO/R injury. These results indicate that KRG has a neuroprotective effect against ischemia/reperfusion brain injury by reducing the level of lipid peroxidation and increasing the endogenous antioxidant enzymatic activity.

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Section: Discussionmentioning

confidence: 99%

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

Ban

Kang

Lee

et al. 2012

Experimental and Therapeutic Medicine

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“…In addition, downregulation of these proteins is involved in regulation of apoptosis via mitochondiral cytochrome c expression/release [26][27][28][29]. We, therefore, postulated that cytochrome c might be a major regulator of the capacitation mechanism or may be involved in regulation in some manner.…”

Section: Localization Of Differentially-expressed Proteins In Sperm Cmentioning

confidence: 99%

Cytochrome c Upregulation during Capacitation and Spontaneous Acrosome Reaction Determines the Fate of Pig Sperm Cells: Linking Proteome Analysis

Choi

Uhm

Song

et al. 2008

Journal of Reproduction and Development

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Abstract.To identify the mechanisms underlying capacitation, we undertook a high-resolution differential proteomic analysis of pig sperm cells. Two-dimensional gel electrophoresis and subsequent MALDI-TOF mass spectrometry analyses led to identification of 56 differentially expressed proteins. After induction of capacitation in vitro, the wellestablished markers of the capacitation (lactadherin P47, acrosomal protein SP-10 precursor, prohibitin, proteasomes, DJ-1 protein and arylsulfatase-A) and TCA cycle proteins (isocitrate dehydrogenase, malate dehydrogenase and pyruvate dehydrogenase) were identified. During induction, cytochrome c expression via the p53 pathway increased, however apoptotic executors, such as caspase-3, decreased significantly. Therefore, we tested the hypothesis that cytochrome c upregulation in spermatozoa is capable of activating tyrosine phosphorylation for capacitation, rather than apoptosis. Exposure of sperm cells to soluble Na2CrO4 [Cr (VI)], which induces cytochrome c upregulation, caused a dose-and time-dependent increase in tyrosine phosphorylation of sperm proteins in non-capacitating medium. In contrast, supplementation of cyclosporin A, which blocks cytochrome c upregulation, inhibited tyrosine phosphorylation of sperm proteins. Furthermore, spermatozoa in capacitation medium or non-capacitation media supplemented with soluble Cr (VI) showed similar levels of capacitation. These findings indicate that differential expression of many of these proteins has previously been unrecognized in sperm cells incubated in capacitation medium also suggest that a gradual increase of cytochrome c during incubation to induce capacitation determines sperm cell fate, i.e., apoptosis or further development for fertilization. Key words: Capacitation, Cytochrome c upregulation, 2-dimensional gel electrophoresis, Pig, Sperm maturation (J. Reprod. Dev. 54: [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83] 2008) permatozoa are terminally differentiated and specialized cells [1]. The deficiencies of major transcriptional and translational activities of sperm are generally known [2] however, recent published evidence shows that sperm are capable of producing major nuclear gene expressions using 55S mitochondrial ribosomes during their residence in the female reproductive tract until fertilization [3]. Mature sperm cells are released from the testis with tightly supercoiled, transcriptionally inert DNA [4]. In addition, they do not exhibit progressive motility, but acquire this ability during passage through the epididymis. These processes are referred to as maturation; other maturational changes include completion of nuclear condensation and changes in the expression and distribution of molecules on the cell surface [1]. Therefore, freshly ejaculated sperm cells are incapable of fertilization and must spend some time in a suitable environment in order to capacitate.Capacitation in all mammals involves shedding of the sperm plasma membrane followed by hyperactivity of the tail, attachme...

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“…High resolution mass spectra were taken on a MicroTOF instrument (APCI or ESI) in positive or negative mode. 1 H and 13 C-NMR were recorded on a Bruker Avance III 300 MHz spectrometer or Bruker 400 spectrometer. All chemical shift values were reported as  (ppm) with the solvent signal as reference, and coupling constant values J were measured in Hz.…”

Section: Experimental Generalmentioning

confidence: 99%

“…Studies have shown that 1 could protect cultured neurons from β-amyloid-induced toxicity and defend neuroblastoma cells against 6-hydroxydopamine, suggesting potential applications for AD and PD, respectively [11,12]. The compound was also studied for protective effects against cerebral ischemia in vivo [13], and traumatic injury in vitro [14]. Its antioxidant activity has been investigated in several models [7,15,16].…”

Section: Introductionmentioning

confidence: 99%

Effects of oxyresveratrol and its derivatives on cultured P19-derived neurons

Tadtong¹,

Chatsumpun²,

Sritularak³

et al. 2017

Trop. J. Pharm Res

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Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia

Cited by 120 publications

References 49 publications

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

Cytochrome c Upregulation during Capacitation and Spontaneous Acrosome Reaction Determines the Fate of Pig Sperm Cells: Linking Proteome Analysis

Effects of oxyresveratrol and its derivatives on cultured P19-derived neurons

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