Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase

Lee, Ju‐Hee; Baek, Su Youn; Jang, Eun Jeong; Ku, Sae Kwang; Kim, Kyu Min; Ki, Sung Hwan; Kim, Chang-Eop; Park, Kwang Il; Kim, Sang Chan; Kim, Young Woo

doi:10.1016/j.cbi.2018.04.023

Cited by 37 publications

(28 citation statements)

References 41 publications

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“…Consistent with the findings in ESRRA null mice, ESRRA inverse agonists, compound 29 (C29) and compound 50 (C50), also show obesity resistance in DIO mouse models [94][95][96]. Recent studies on the ESRRA activator, genistein, have shown beneficial effects in preclinical dietary NAFLD models, as well as in a randomized, controlled clinical trial on NAFLD patients [97][98][99][100][101]. Genistein increases AMPK activity, lipid catabolism, and mitochondrial activity, while reducing de novo lipogenesis.…”

Section: Esrra As a Target For Nafldsupporting

confidence: 64%

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi

Yen

Singh

2020

IJMS

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The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism.ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

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Section: Esrra As a Target For Nafldsupporting

confidence: 64%

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi

Yen

Singh

2020

IJMS

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“…MMP9 (a member of the MMP family, encoded by Mmp9 ) is secreted by adipocytes, and its proteolytic activity was induced during adipocyte differentiation [ 34 ]. The Nr1h3 gene encodes a nuclear receptor, Nuclear Receptor Subfamily 1 Group H Member 3 (NR1H3, also known as LXRα), which is a vital regulator in hepatic de novo lipogenesis and lipid homeostasis [ 35 ]. NR1H3 exhibits ligand-dependent activation activity and is activated primarily by cellular cholesterols, leading to the induction of transcription of a downstream nuclear transcriptional factor, sterol regulatory element binding transcription factor 1 (SREBF1) [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Key Genes Associated with Adipogenesis through Integrated Analysis of Five Mouse Transcriptome Datasets

Zhang

Wang

et al. 2018

IJMS

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Adipose tissue is the most important energy metabolism and secretion organ, and these functions are conferred during the adipogenesis process. However, the cause and the molecular events underlying adipogenesis are still unclear. In this study, we performed integrated bioinformatics analyses to identify vital genes involved in adipogenesis and reveal potential molecular mechanisms. Five mouse high-throughput expression profile datasets were downloaded from the Gene Expression Omnibus (GEO) database; these datasets contained 24 samples of 3T3-L1 cells during adipogenesis, including 12 undifferentiated samples and 12 differentiated samples. The five datasets were reanalyzed and integrated to select differentially expressed genes (DEGs) during adipogenesis via the robust rank aggregation (RRA) method. Functional annotation of these DEGs and mining of key genes were then performed. We also verified the expression levels of some potential key genes during adipogenesis. A total of 386 consistent DEGs were identified, with 230 upregulated genes and 156 downregulated genes. Gene Ontology (GO) analysis showed that the biological functions of the DEGs primarily included fat cell differentiation, lipid metabolic processes, and cell adhesion. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were mainly associated with metabolic pathways, the peroxisome proliferator-activated receptor (PPAR) signaling pathway, regulation of lipolysis in adipocytes, the tumor necrosis factor (TNF) signaling pathway, and the FoxO signaling pathway. The 30 most closely related genes among the DEGs were identified from the protein–protein interaction (PPI) network and verified by real-time quantification during 3T3-L1 preadipocyte differentiation. In conclusion, we obtained a list of consistent DEGs during adipogenesis through integrated analysis, which may offer potential targets for the regulation of adipogenesis and treatment of adipose dysfunction.

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“…Non-alcoholic fatty liver disease (NAFLd) is a stress-induced liver disease, which is characterized by excess accumulation of lipid droplets in hepatocytes and diffused steatosis without excessive alcohol consumption (1,2). The incidence of NAFLD as well as that of metabolic syndrome is on the increase (3,4).…”

Section: Introductionmentioning

confidence: 99%

Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

et al. 2019

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Non-alcoholic fatty liver disease (NAFLd) is characterized by hepatic steatosis, insulin resistance and inflammation; however, the exact pathogenesis of NAFLD is not fully understood. Green tea polyphenols (GTP) exhibit beneficial effects against metabolic syndrome. However, the effect of GTP on NAFLD remains largely unknown. The aim of the present study was to investigate the effects of GTP on NAFLD in high-fat diet (HFD)-induced rats. The NAFLD rat model was induced with a HFD for 8 weeks. A total of 30 adult male Sprague Dawley rats were randomly divided into three groups: i) Normal control group; ii) HFD group; and iii) HFD with GTP group. Hematoxylin and eosin and Oil Red O analyses were performed. The levels of alanine aminotransferase (ALT), aspartate amino transferase (AST) and inflammatory cytokines in the serum, as well as oxidative stress markers and hepatic lipids in the liver were measured. In addition, parameters associated with glucose metabolism were also assessed. Western blotting and RT-qPCR were used to determine the expression levels of 5' adenosine monophosphate-activated protein kinase (AMPK). HFD-induced rats exhibited features associated with NAFLD. GTP intervention significantly reduced serum ALT and AST levels. Fasting serum glucose, insulin resistance and hepatic lipid levels were all decreased in the GTP-treated rats. GTP also significantly decreased the levels of TNF-α, IL-6 and malondialdehyde. In contrast, superoxide dismutase levels were increased in the liver. Furthermore, GTP also significantly increased phosphorylation of AMPK and attenuated histopathological changes indicative of injury in liver tissue. GTP has a protective effect on HFD-induced hepatic steatosis, insulin resistance and inflammation, and the underlying mechanism may involve the AMPK pathway.

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Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase

Cited by 37 publications

References 41 publications

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Identification of Potential Key Genes Associated with Adipogenesis through Integrated Analysis of Five Mouse Transcriptome Datasets

Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

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