Oxyphil Cells of Parathyroid Glands in Chronic Renal Failure May Not Secrete Parathyroid Hormone

Suzuki, Yuichi; Suzuki, Masashi; Hirasawa, Yoshihei; Morita, Takashi; Shimizu, Takahiro; Arakawa, Masaaki

doi:10.1159/000186102

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Many points remain unclear, however, with respect to the significance of this findil~g, and consensus has not been obtained. The cells were suggested not to produce parathyroid hormone in an earlier report [22], but more recent reports have indicated they may produce the hormone [23,24]. Generally, proliferation of oxyphilic cells is considered to increase along with increased hyperplasia [21].…”

Section: Discussionmentioning

confidence: 99%

Expression of basic fibroblast growth factor in hyperplastic parathyroid glands from patients with multiple endocrine neoplasia type I

Komatsu

Tsuchiya²,

Matsuyama³

et al. 1994

World j. surg.

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Primary hyperparathyroidism was investigated using the presence of basic fibroblast growth factor (bFGF) from the immunohistochemical viewpoint with an anti-bFGF antibody in hyperplastic parathyroid glands of patients with multiple endocrine neoplasia type I (MEN-I) and of patients with non-MEN. The results corresponded well with the data from the DNA analysis. Twenty-five hyperplastic parathyroid glands from 11 patients with MEN-I and 38 glands from 20 patients with non-MEN primary hyperparathyroidism were stained immunohistochemically according to the avidin-biotin-peroxidase complex procedure. When 50% or more of the cells appeared uniformly stained, it was judged positively stained. In addition, 18 hyperplastic parathyroid glands from patients with MEN-I patients and 24 hyperplastic parathyroid glands from non-MEN patients were also analyzed for DNA using flow cytometry. The ratio of positively stained hyperplastic parathyroid glands was 72% in MEN-I patients and 18% in non-MEN patients. The difference between the two groups was significant (p < 0.01). The nodules consisted of oxyphilic cells in 7 of 25 hyperplastic parathyroid glands from MEN-I patients and in 10 of 38 hyperplastic parathyroid glands from non-MEN patients, and all the cells were positive for bFGF. There was no significant correlation between bFGF staining and the DNA ploidy pattern. bFGF possibly plays a role in the development of parathyroid gland hyperplasia, especially in MEN-I patients. The increase of oxyphilic cells may be correlated with the expression of bFGF.

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Section: Discussionmentioning

confidence: 99%

Expression of basic fibroblast growth factor in hyperplastic parathyroid glands from patients with multiple endocrine neoplasia type I

Komatsu

Tsuchiya²,

Matsuyama³

et al. 1994

World j. surg.

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“…Tominaga et al [19] and Roth [23] reported that there is a remarkable increase in mitochondria with suppression of the surrounding structures in the oxyphilic cells of hemodialysis patients. Moreover, Suzuki et al [24] showed that lack of oxyphilic cell secretion in normal tissue was due to deficient protein synthesis. However, secretion of oxyphilic cells associated with tumorous change has been shown [25,26], and Ron do et al [27] confirmed the existence of rough-surfaced endoplasmic reticulum, Golgi's apparatus and secretory granules in oxyphilic cells.…”

Section: Discussionmentioning

confidence: 99%

Cellular Proliferation and Secretion in Secondary Hyperparathyroidism during Renal Failure

Fujisaki¹,

Hida²,

Hiraga³

et al. 1997

Nephron

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Secondary hyperparathyroidism is one of the severe complications of chronic renal failure. In this study, we investigated the cellular components of parathyroid tissue, with measurements of various serum parathyroid hormone (PTH) types in the circulation, and evaluated their clinical significance in hemodialysis patients. Thirty-eight patients who underwent both subtotal parathyroidectomy and autotransplantation in Tokai University Hospital from 1979 to 1994 were divided into two groups. Group 1 (G-1) was not administered active-type vitamin D₃ (VD; 19 patients; 15 males and 4 females), and group 2 (G-2) was administered VD (19 patients; 10 males and 9 females). The parathyroid tissues which were obtained from G-1 and G-2 patients were classified into three classes based on the size of the oxyphilic cell area (class I < 25%, class II25-50% and class III > 50%). Our results showed that the proliferation index of parathyroid tissues in the oxyphilic cell area was higher in G-2 than that in G-1. Immunohistochemically, MIB-1 staining was more intense than that in the chief cell area in G-2 patients. Moreover, the proliferative index in the same specimen was also higher in the oxyphilic cell area than in the chief cell area. It was suggested that the oxyphilic cells proliferated independently. Furthermore, synthesis of PTH in the oxyphilic cell area was revealed immunohistochemically by the presence of PTH and was confirmed by positive staining of PTH mRNA in the oxyphilic cell area with in situ hybridization. HS(M-terminal)- and C-PTH levels in the serum were significantly higher in class III than in class I (p < 0.01). No significant difference of HS- and C-PTH levels between class II and class III was noted. Moreover, no significant difference of intact-PTH levels was found in all three classes. From the above findings, it was suggested that proliferation of the parathyroid tissues or secretory state of PTH in hemodialysis-maintained patients with secondary hyperparathyroidism, which was closely related to the proliferation of oxyphilic cells, can be more accurately reflected by HS- and C-PTH levels than by the intact-PTH level. Therefore, it was suggested that HS- and C-PTH levels in the serum are important indices for accurate evaluation of the pathology and suitable therapy of secondary hyperparathyroidism, as well as observation of the clinical course.

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“…Additionally, it has been reported that serum PTH levels do not have a statistically significant relationship with age and the dialysis duration; however, the total tissue size is positively correlated with PTH release. Based on the results, they concluded that the oxyphil cell/total tissue area was not effective in PTH release in patients with chronic renal failure [41].…”

Section: Oxyphil Cellsmentioning

confidence: 99%

Evaluation of Parathyroid Pathophysiology via Cell Distribution and Expression Patterns

Göncü¹

2023

Parathyroid Glands - New Aspects

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The parathyroid tissue is composed of the chief, oxyphil, and water-clear cells. The cell type in each parathyroid gland is highly heterogeneous between different pathologies. The parathyroid oxyphil cells are markedly increased in secondary hyperparathyroidism due to chronic kidney diseases. These cells include more eosinophil than oxyphil cells, but they are closer in size to the chief cells. Studies reported that the oxyphil cells are derived from chief cells, and this presents another cell type that occurs as “transitional oxyphilic cells.” As is known, calcium-sensing receptor (CaSR) is expressed abundantly in the chief cells. Expression of CaSR is elevated in disparate parathyroid tissues, which is possibly related to differential expression levels of parathyroid-specific transcription factors including GCM2 (Glial Cells Missing Transcription Factor 2), MAFB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B), GATA3 (GATA Binding Protein 3), RXR (The retinoid X receptor), and even VDR (Vitamin D Receptor). The pathways that connect CaSR to parathyroid cell proliferation are precisely not known yet. Evaluation of oxyphil and chief cells of parathyroid glands and their differential expression patterns are important to understand the parathyroid function and its behavioral changes due to related diseases. This chapter presents a summary of the current literature on the cell type distribution of parathyroid and pathophysiology by comparing the expression patterns.

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Oxyphil Cells of Parathyroid Glands in Chronic Renal Failure May Not Secrete Parathyroid Hormone

Cited by 4 publications

References 14 publications

Expression of basic fibroblast growth factor in hyperplastic parathyroid glands from patients with multiple endocrine neoplasia type I

Expression of basic fibroblast growth factor in hyperplastic parathyroid glands from patients with multiple endocrine neoplasia type I

Cellular Proliferation and Secretion in Secondary Hyperparathyroidism during Renal Failure

Evaluation of Parathyroid Pathophysiology via Cell Distribution and Expression Patterns

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