Oxymetazoline vs ofloxacin vs ciprofloxacin/dexamethasone- effects of drops on tympanostomy tube postoperative otorrhea

McManus, Brian; Townsend, William; Stuart, Kinsley; Paul, Oishika; Spankovich, Christopher; Carron, Jeffrey D.

doi:10.1016/j.amjoto.2022.103580

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Lomefloxacin (see Figure 1) is a third-generation difluorinated quinolone antibacterial agent. 1,2 Lomefloxacin hydrochloride ear drops are indicated for the treatment of otitis media, otitis externa and tympanites caused by sensitive bacteria. 3,4 This product is very unstable to light, easily producing photodegradation impurities.…”

Section: Introductionmentioning

confidence: 99%

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Study of the impurity profile of photodegradation in lomefloxacin hydrochloride ear drops using liquid chromatography combined with ion trap/time‐of‐flight mass spectrometry

Zeng,

Yang,

Gao

et al. 2024

Rapid Comm Mass Spectrometry

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RationaleLomefloxacin hydrochloride ear drops are highly unstable to light and prone to produce photodegradation impurities. These impurities might be related to the phototoxicity of lomefloxacin, which could seriously threaten the health of patients. In this article, the photodegradation impurity profile in lomefloxacin hydrochloride ear drops was studied for further improvement of quality control of the drug.MethodsBy studying the chromatographic behavior of photodegradation impurities, the photodegradation impurities in lomefloxacin hydrochloride ear drops were separated and detected effectively. Liquid chromatography combined with ion trap/time‐of‐flight mass spectrometry was applied to characterize the structures of the photodegradation impurities in lomefloxacin hydrochloride ear drops.ResultsThe structures of 17 impurities in lomefloxacin hydrochloride ear drops were elucidated based on high‐resolution MSn data in positive ion mode, 12 of them being unknown impurities.ConclusionsThe structural characteristics and fragmentation patterns of the photodegradation impurities were also studied. The study of the photodegradation impurity profile in lomefloxacin hydrochloride ear drops provides a scientific basis for quality control of these ear drops and ensures the safety of drug use by the public.

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Section: Introductionmentioning

confidence: 99%

“… Figure S1. The known impurities of lomefloxacin hydrochloride (A) in literature 1, 1 and (B) in literature 2 2 …”

mentioning

confidence: 99%

Study of the impurity profile of photodegradation in lomefloxacin hydrochloride ear drops using liquid chromatography combined with ion trap/time‐of‐flight mass spectrometry

Zeng,

Yang,

Gao

et al. 2024

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic

Pelton,

Hullegie,

Leach

et al. 2024

International Journal of Pediatric Otorhinolaryngology

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Study on the impurity profile and influencing factors of photodegradation in non-aqueous ofloxacin ear drops using liquid chromatography combined with ion trap/time-of-flight mass spectrometry

Gao

Zhu

et al. 2023

Journal of Pharmaceutical and Biomedical Analysis

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Oxymetazoline vs ofloxacin vs ciprofloxacin/dexamethasone- effects of drops on tympanostomy tube postoperative otorrhea

Cited by 3 publications

References 18 publications

Study of the impurity profile of photodegradation in lomefloxacin hydrochloride ear drops using liquid chromatography combined with ion trap/time‐of‐flight mass spectrometry

Study of the impurity profile of photodegradation in lomefloxacin hydrochloride ear drops using liquid chromatography combined with ion trap/time‐of‐flight mass spectrometry

ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic

Study on the impurity profile and influencing factors of photodegradation in non-aqueous ofloxacin ear drops using liquid chromatography combined with ion trap/time-of-flight mass spectrometry

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