Oxymatrine liposome attenuates hepatic fibrosis<i>via</i>targeting hepatic stellate cells

Chai, Ningli; Fu, Qiang; Shi, Hui; Cai, Chao; Wan, Jun; Xu, Shi-Ping; Wu, Bing

doi:10.3748/wjg.v18.i31.4199

Cited by 77 publications

(47 citation statements)

References 32 publications

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“…CHM has been used as a complementary and alternative therapy in disease prevention for centuries and is potent for preventing liver fibrosis. Currently, a number of anti-liver fibrosis compounds have been discovered from CHM in various forms such as oxymatrine [21], matrine [22], tetrandrine [23], silybin [24], puerarin [25], quercetin [26], salvianolic acid B [27], curcumin [28] and so on. Paeoniflorin, serving as an effective anti-liver fibrosis compound, displays its function via a variety of signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Yan

Wang

et al. 2014

Fitoterapia

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Section: Discussionmentioning

confidence: 99%

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Yan

Wang

et al. 2014

Fitoterapia

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“…OMT has been reported to have various medicinal qualities, including antiviral [7], antifibrotic [8], anti-inflammatory [9], and antiarrhythmic [10] effects, and is also widely used in China for the treatment of chronic hepatitis B. Previous in vitro and in vivo studies have shown that OMT inhibits cell proliferation and induces apoptosis in various types of cancers [11–15].…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

Liu

Wang

et al. 2016

BioMed Research International

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Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer cells. In this study, we investigate the anticancer properties of OMT on human glioblastoma (GBM) cells and evaluate their underlying mechanisms. MTT assays were performed and demonstrated that OMT significantly inhibits the proliferation of GBM cells. Flow cytometry suggested that OMT at a concentration of 10−5 M may induce apoptosis in U251 and A172 cells. Western blot analyses demonstrated a significant increase in the expression of Bax and caspase-3 and a significant decrease in expression of Bcl-2 in both U251 and A172 cells. Additionally, OMT was found by transwell and high-content screening assays to decrease the migratory ability of the evaluated GBM cells. These findings suggest that the antitumor effects of OMT may be the result of inhibition of cell proliferation and migration and the induction of apoptosis by regulating the expression of apoptosis-associated proteins. OMT may represent a novel anticancer therapy for the treatment of GBM.

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“…et al, 2013;Pan et al, 2015). In the past few years, much more attention has been paid to the analysis of alkaloids in RST, including matrine, oxymatrine, and sophocarpine, due to their various pharmacological activities, which include ameliorating throat inflammation (Li et al, 2012;Yoo et al, 2014;Lee et al, 2015) and suppressing in vitro cancer cell proliferation (Chui et al, 2005;Liu et al, 2006) as well as hepatoprotective effects (Cho et al, 1986;Long et al, 2004;Chai et al, 2012). Unfortunately, some of the alkaloids extracted from RST have been shown to be highly toxic to humans and livestock in ways that damage the nervous system, digestive system, and respiratory system, affecting cardiovascular and liver functions.…”

Section: Introductionmentioning

confidence: 99%

Toxicity comparison of different active fractions extracted from radix Sophorae tonkinensis in zebrafish

Liu

Zhu²,

Chen

et al. 2017

J. Zhejiang Univ. Sci. B

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Abstract:Radix Sophorae tonkinensis (RST) is a widely used herb in Traditional Chinese Medicine (TCM) for treating infectious and inflammatory diseases. However, the toxicity data for RST are limited. The aim of this work is to assess and compare the toxicity of the whole RST extract and its five active fractions using the zebrafish model. Five active fractions of RST were prepared using five different types of solvents, which included dealkalized water, ethanol, n-butyl ethanol, dichloromethane, and diethyl ether. The chemical profiles of the active fractions were determined by high-performance liquid chromatography (HPLC), and the toxicity observed in the zebrafish model was confirmed using mouse models. In the zebrafish model, cardiovascular toxicity was observed for the fraction extracted using diethyl ether, and hepatotoxicity was observed for the whole RST extract and the fractions extracted using water and ethanol, whereas both cardiovascular and hepatic toxicities were observed for the fractions extracted using n-butyl ethanol and dichloromethane. The hepatotoxicity of the fractions extracted using n-butyl ethanol and dichloromethane was also observed in mice. Our findings provide the toxicity data for RST and its five active fractions through modeling in a zebrafish, and indicate that the different fractions may each have a different toxicity, which is helpful for the optimal use of RST in clinical practice.

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Oxymatrine liposome attenuates hepatic fibrosisviatargeting hepatic stellate cells

Abstract: OM attenuated hepatic fibrosis by inhibiting viability and inducing apoptosis of HSCs. The RGD-labeled formulation enhanced the targeting efficiency for HSCs and the therapeutic effect.

Cited by 77 publications

References 32 publications

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

Toxicity comparison of different active fractions extracted from radix Sophorae tonkinensis in zebrafish

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