2012
DOI: 10.3748/wjg.v18.i31.4199
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Oxymatrine liposome attenuates hepatic fibrosisviatargeting hepatic stellate cells

Abstract: OM attenuated hepatic fibrosis by inhibiting viability and inducing apoptosis of HSCs. The RGD-labeled formulation enhanced the targeting efficiency for HSCs and the therapeutic effect.

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Cited by 77 publications
(47 citation statements)
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“…CHM has been used as a complementary and alternative therapy in disease prevention for centuries and is potent for preventing liver fibrosis. Currently, a number of anti-liver fibrosis compounds have been discovered from CHM in various forms such as oxymatrine [21], matrine [22], tetrandrine [23], silybin [24], puerarin [25], quercetin [26], salvianolic acid B [27], curcumin [28] and so on. Paeoniflorin, serving as an effective anti-liver fibrosis compound, displays its function via a variety of signaling pathways.…”
Section: Discussionmentioning
confidence: 99%
“…CHM has been used as a complementary and alternative therapy in disease prevention for centuries and is potent for preventing liver fibrosis. Currently, a number of anti-liver fibrosis compounds have been discovered from CHM in various forms such as oxymatrine [21], matrine [22], tetrandrine [23], silybin [24], puerarin [25], quercetin [26], salvianolic acid B [27], curcumin [28] and so on. Paeoniflorin, serving as an effective anti-liver fibrosis compound, displays its function via a variety of signaling pathways.…”
Section: Discussionmentioning
confidence: 99%
“…OMT has been reported to have various medicinal qualities, including antiviral [7], antifibrotic [8], anti-inflammatory [9], and antiarrhythmic [10] effects, and is also widely used in China for the treatment of chronic hepatitis B. Previous in vitro and in vivo studies have shown that OMT inhibits cell proliferation and induces apoptosis in various types of cancers [1115].…”
Section: Introductionmentioning
confidence: 99%
“…et al, 2013;Pan et al, 2015). In the past few years, much more attention has been paid to the analysis of alkaloids in RST, including matrine, oxymatrine, and sophocarpine, due to their various pharmacological activities, which include ameliorating throat inflammation (Li et al, 2012;Yoo et al, 2014;Lee et al, 2015) and suppressing in vitro cancer cell proliferation (Chui et al, 2005;Liu et al, 2006) as well as hepatoprotective effects (Cho et al, 1986;Long et al, 2004;Chai et al, 2012). Unfortunately, some of the alkaloids extracted from RST have been shown to be highly toxic to humans and livestock in ways that damage the nervous system, digestive system, and respiratory system, affecting cardiovascular and liver functions.…”
Section: Introductionmentioning
confidence: 99%