Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats

Zhao, Jingwen; Sato, Yu; Tong, Lei; Zhang, Feng; Jiang, Xian; Pan, Shangha; Jiang, Hongchi; Sun, Xueying

doi:10.1007/s00595-008-3785-8

Cited by 46 publications

(31 citation statements)

References 34 publications

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“…It is proven to protect ischemic and reperfusion injury in liver, intestine and heart via anti-inflammation and antiapoptosis [12,21,22]. Recently, several studies have confirmed that OMT protects the brain from ischemic injury by an inhibition of the inflammatory reaction.…”

Section: Discussionmentioning

confidence: 99%

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Dong

et al. 2010

Inflamm. Res.

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Section: Discussionmentioning

confidence: 99%

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Dong

et al. 2010

Inflamm. Res.

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“…OMT has been proved to have a variety of biological effects in treatment of viral hepatitis 8 , bronchial asthma 9 and ischemic injuries [10][11][12][13][14][15][16]22 , and plays a role in scavenging activity against reactive oxygen species 18 . In view of these considerations, we tested the therapeutic potentials of OMT on renal I/R injury rat model.…”

Section: Discussionmentioning

confidence: 99%

“…, liver 12 , intestinal 13 and brain [14][15][16] ischemia/reperfusion injury in animal models. OMT also have a protective role in adriamycin-induced chronic renal fibrosis 17 .…”

mentioning

confidence: 99%

Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway

et al. 2015

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PURPOSE:To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway. METHODS:Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed. RESULTS:Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins. CONCLUSION:Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway.

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“…(Kushen) that has been approved by the State Food and Drug Administration of China for treating hepatitis B (7,8). Cumulative evidence has suggested that OM possesses multiple biological and pharmacological properties, such as anti-inflammatory (9)(10)(11), antitumor (12,13), anti-apoptotic (14), antifibrotic (15), antioxidant (16), and antiarrhythmic activities (17). Chen et al (18) demonstrated that…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Liu

Lü

et al. 2012

Int J Mol Med

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Abstract. Oxymatrine (OM) is an alkaloid extracted from the Chinese herb Sophora flavescens Ait. with a variety of pharmacological activities. The aim of this study was to investigate the preventive effects of OM on bleomycin (BLM)-induced pulmonary fibrosis (PF) and to further explore the underlying mechanisms. C57BL/6 mice were randomly assigned to five groups: the saline sham group; the BLM group, in which mice were endotracheally instilled with BLM (3.0 mg/kg); and the BLM plus OM groups, in which OM was given to mice daily (10, 20 or 40 mg/kg) one day after BLM instillation for 21 days. The bronchoalveolar lavage fluid (BALF) and lung tissues were collected at 15 and 22 days post BLM administration, respectively. Lung tissues were stained with hematoxylin and eosin (H&E) for histological evaluation. Levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6) and nitric oxide (NO) in mouse BALF were measured, as well as myeloperoxidase (MPO) activity and malondialdehyde (MDA) content in lung homogenates. The inducible nitric oxide synthase (iNOS) expression in the lung tissues was determined by immunohistochemical staining, quantitative real-time PCR and western blot analysis. Moreover, the expression of transforming growth factor (TGF)-β1, Smad2, Smad3, p-Smad2 and p-Smad3 were also detected. We found that OM improved BLM-induced lung pathological changes, inhibited MPO activity and reduced MDA levels in a dose-dependent manner. OM also dose-dependently inhibited the release of TNF-α and IL-6, and decreased the expression of iNOS in lung tissues and thus prevented NO release in response to BLM challenge. In addition, OM decreased the expression of TGF-β1, p-Smad2 and p-Smad3, which are all important members of the TGF-β/ Smad signaling pathway. Our study provides evidence that OM significantly ameliorated BLM-induced PF in mice via the inhibition of iNOS expression and the TGF-β/Smad pathway.

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Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats

Abstract: These results provide further evidence of the anti-inflammatory and anti-apoptotic activities of oxymatrine, which may become a potent drug for protecting the intestines against I/R injury.

Cited by 46 publications

References 34 publications

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

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