Oxylipins and oxylipin synthesis pathways in fungi

Гесслер, Н. Н.; Filippovich, S. Yu.; Бачурина, Г. П.; Kharchenko, E. A.; Groza, N. V.; Belozerskaya, T. A.

doi:10.1134/s0003683817060060

Cited by 21 publications

(26 citation statements)

References 114 publications

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“…In fungi, oxylipins are responsible for a range of signaling functionalities and act as paracrine hormone-like substances or as so-called 'infochemicals' (Combet et al 2006;Holighaus and Rohlfs 2019). Ascomycota species produce diverse oxylipin compounds (reviewed in (Gessler et al 2017)) and changes in their levels influence development. For example, oxylipins can regulate the yeast-to-hypha transition in dimorphic fungi, as well as immune evasion (Rennemeier et al 2011) and communication with the host in pathogens, while a well-known group of oxylipins called psi (precocious sexual inducer) factors regulates sexual and asexual development in Ascomycota (Tsitsigiannis and Keller 2007).…”

Section: Oxylipinsmentioning

confidence: 99%

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Nagy

Vonk

Künzler

et al. 2021

Preprint

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Fruiting bodies of mushroom-forming fungi (Agaricomycetes) are among the most complex structures produced by fungi. Unlike vegetative hyphae, fruiting bodies grow determinately and follow a genetically encoded developmental program that orchestrates tissue differentiation, growth and sexual sporulation. In spite of more than a century of research, our understanding of the molecular details of fruiting body morphogenesis is limited and a general synthesis on the genetics of this complex process is lacking. In this paper, we aim to comprehensively identify conserved genes related to fruiting body morphogenesis and distill novel functional hypotheses for functionally poorly characterized genes. As a result of this analysis, we report 921 conserved developmentally expressed gene families, only a few dozens of which have previously been reported in fruiting body development. Based on literature data, conserved expression patterns and functional annotations, we provide informed hypotheses on the potential role of these gene families in fruiting body development, yielding the most complete description of molecular processes in fruiting body morphogenesis to date. We discuss genes related to the initiation of fruiting, differentiation, growth, cell surface and cell wall, defense, transcriptional regulation as well as signal transduction. Based on these data we derive a general model of fruiting body development, which includes an early, proliferative phase that is mostly concerned with laying out the mushroom body plan (via cell division and differentiation), and a second phase of growth via cell expansion as well as meiotic events and sporulation. Altogether, our discussions cover 1480 genes of Coprinopsis cinerea, and their orthologs in Agaricus bisporus, Cyclocybe aegerita, Armillaria ostoyae, Auriculariopsis ampla, Laccaria bicolor, Lentinula edodes, Lentinus tigrinus, Mycena kentingensis, Phanerochaete chrysosporium, Pleurotus ostreatus, and Schizophyllum commune, providing functional hypotheses for ~10% of genes in the genomes of these species. Although experimental evidence for the role of these genes will need to be established in the future, our data provide a roadmap for guiding functional analyses of fruiting related genes in the Agaricomycetes. We anticipate that the gene compendium presented here, combined with developments in functional genomics approaches will contribute to uncovering the genetic bases of one of the most spectacular multicellular developmental processes in fungi. Key words: functional annotation; comparative genomics; cell wall remodeling; development; fruiting body morphogenesis; mushroom; transcriptome

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Section: Oxylipinsmentioning

confidence: 99%

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Nagy

Vonk

Künzler

et al. 2021

Preprint

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“…Like SDA, jasmonates are formed from linolenic acid in plant chloroplasts. Some oxylipins are distasteful to insect predators, and others can elicit a signal of cell damage throughout the plant to coordinate a comprehensive response (Gessler et al 2017). Linolenic and linoleic acid production was also found to increase in tomato plants parasitized by the parasitic plant, Cuscuta pentagona Engelm., similar to the chemical response tomato plants display when attacked by herbivores or pathogens (Runyon et al 2010).…”

Section: Metabolites Elevated In Rafflesia-infected Tetrastigma Loherimentioning

confidence: 99%

Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia (Rafflesiaceae) and potential applications for propagation

Molina

Nikolić

Jeevarathanam

et al. 2021

Planta

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Main conclusion Metabolites in Rafflesia-infected and non-infected Tetrastigma were compared which may have applications in Rafflesia propagation. Benzylisoquinoline alkaloids, here reported for the first time in Vitaceae, were abundant in non-infected shoots and may be a form of defense. In Rafflesia-infected shoots, oxylipins, which mediate immune response, were elevated. Abstract Endemic to the forests of Southeast Asia, Rafflesia (Rafflesiaceae) is a genus of holoparasitic plants producing the largest flowers in the world, yet completely dependent on its host, the tropical grape vine, Tetrastigma. Rafflesia species are threatened with extinction, making them an iconic symbol of plant conservation. Thus far, propagation has proved challenging, greatly decreasing efficacy of conservation efforts. This study compared the metabolites in the shoots of Rafflesia-infected and non-infected Tetrastigma loheri to examine how Rafflesia infection affects host metabolomics and elucidate the Rafflesia infection process. Results from LC–MS-based untargeted metabolomics analysis showed benzylisoquinoline alkaloids were naturally more abundant in non-infected shoots and are here reported for the first time in the genus Tetrastigma, and in the grape family, Vitaceae. These metabolites have been implicated in plant defense mechanisms and may prevent a Rafflesia infection. In Rafflesia-infected shoots, oxygenated fatty acids, or oxylipins, and a flavonoid, previously shown involved in plant immune response, were significantly elevated. This study provides a preliminary assessment of metabolites that differ between Rafflesia-infected and non-infected Tetrastigma hosts and may have applications in Rafflesia propagation to meet conservation goals.

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“…Oxylipins are oxygenated fatty acids, that are abundantly present in almost all organisms. Oxylipins in fungi play several functions such as differentiation, growth regulation, reproduction (sexual and asexual), secondary metabolites production (antibodies and mycotoxins), and as QSMs [50,68]. The biosynthesis of oxylipin in fungi is not well characterized compared to that of mammals and plants.…”

Section: Quorum Sensing Molecules (Qsms)mentioning

confidence: 99%

“…involved in the synthesis of oxylipins. The detail of the biosynthesis of fungal oxlipins is depicted in Figure 5 [68]. Oxylipins synthesis and secretion in fungi cells represents the putative role of these molecules as QSMs.…”

Section: Quorum Sensing Molecules (Qsms)mentioning

confidence: 99%

Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review

et al. 2019

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The theory of persisting independent and isolated regarding microorganisms is no longer accepted. To survive and reproduce they have developed several communication platforms within the cells which facilitates them to adapt the surrounding environmental changes. This cell-to-cell communication is termed as quorum sensing; it relies upon the cell density and can stimulate several traits of microbes including biofilm formation, competence, and virulence factors secretion. Initially, this sophisticated mode of communication was discovered in bacteria; later, it was also confirmed in eukaryotes (fungi). As a consequence, many quorum-sensing molecules and inhibitors have been identified and characterized in various fungal species. In this review article, we will primarily focus on fungal quorum-sensing molecules and the production of inhibitors from fungal species with potential applications for combating fungal infections.

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Oxylipins and oxylipin synthesis pathways in fungi

Cited by 21 publications

References 114 publications

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia (Rafflesiaceae) and potential applications for propagation

Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review

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