Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome

Brizel, D.M.; Scher, Richard L.; Dewhirst, Mark W.

doi:10.1016/s0360-3016(98)80147-8

Cited by 145 publications

(191 citation statements)

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“…4,5,8 This has been well studied in the head and neck, and uterine cervix. [5][6][7] Significant correlation of HIF-1a was also noted with radiotherapy treatment of oropharyngeal and cervical carcinomas. [5][6][7][8]21 Overexpression of HIF-1a has also been described in endometrial carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Significant correlation of HIF-1a was also noted with radiotherapy treatment of oropharyngeal and cervical carcinomas. [5][6][7][8]21 Overexpression of HIF-1a has also been described in endometrial carcinomas. 11 Sivridis et al found HIF-1a overexpression in 49% of 81 low-stage endometrioid adenocarcinomas (type I endometrial adenocarcinoma).…”

Section: Discussionmentioning

confidence: 99%

“…Positive tumors were further categorized into groups by the percent of cells stained. [7][8][9][10] HIF-1a was expressed in both nuclei and cytoplasm. Expression of HIF-1a was assessed by analyzing at least 1000 tumor cells from tumor fields, and the labeling index was calculated as the percentage of labeled nuclei of the total number of tumor cells that were counted.…”

Section: Assessment Of Antibody Expressionsmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11]20 The negative impact of HIF-1a protein overexpression on prognosis has been shown in cancers of head and neck, cervix and soft tissue sarcomas. [5][6][7][8][9][10] It has been suggested that tumor hypoxia makes solid tumors resistant to radiation and chemotherapy. High expression of HIF-1a was also associated with resistance to radiotherapy treatment of oropharyngeal and cervical carcinomas.…”

Section: Myometrial Invasionmentioning

confidence: 99%

“…3,4 Importantly, hypoxia has been clinically demonstrated to predict an adverse treatment outcome in the radiotherapeutic management of cancer of the head and neck, uterine cervix and soft tissue sarcomas. [5][6][7][8][9][10] Upregulation of HIF-1a has also been identified in low-stage endometrioid adenocarcinomas. 11 However, its role in other types of endometrial carcinoma and its association with prognosis and survival have not been well documented in literature.…”

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confidence: 99%

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Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

et al. 2007

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Hypoxia-inducible factor 1a (HIF-1a) is a nuclear protein that is upregulated in many tumors and triggers biologic events intimately associated with aggressive tumor behavior. The aim of this study was to analyze the expression of HIF-1a, vascular endothelial growth factor (VEGF), Ki-67 and p53 in type I and type II endometrial adenocarcinoma. In total, 149 patients diagnosed with endometrial adenocarcinoma in our institute from 1995 to 2001 were included in this study, of which 108 were type I and 41 were type II endometrial adenocarcinoma. Patient demographics, clinical and pathological data were reviewed. Tissue microarrays were prepared from the paraffin blocks and immunohistochemistry was performed for antibodies against HIF-1a, VEGF, Ki-67 and p53. High expression of HIF-1a, VEGF, Ki-67 and p53 were significantly more frequent in type II than type I endometrial adenocarcinoma (Po0.001). HIF-1a expression was highly correlated with VEGF expression in the tumor cells (P ¼ 0.001). In type I endometrial adenocarcinoma, high expression of HIF-1a showed a significant correlation with higher grade of the tumor, depth of myometrial invasion, adnexal invasion and clinical stage. A similar correlation was not observed in type II endometrial adenocarcinoma. Surgical stage was the only independent prognostic marker for survival. In conclusion, high expression of HIF-1a is more frequent in type II than in type I endometrial adenocarcinoma. In type I endometrial adenocarcinoma, HIF-1a expression correlates with morphologic features of aggressiveness. In type II endometrial adenocarcinoma, there is no correlation between HIF-1a expression and these features. Thus, HIF-1a may play an important role in endometrial adenocarcinoma progression, particularly in type I endometrial adenocarcinoma. Additional investigations of HIF-1a as a biomarker of aggressive potential and as a novel target for therapeutics in endometrial adenocarcinoma are warranted. Hypoxia-inducible factor 1 (HIF-1) is a nuclear protein that activates gene transcription specifically in response to reduced cellular oxygen concentration and therefore acts as a marker for hypoxia. It is a dimeric protein with two subunits, a and b. HIF-1a is the specific hypoxia-regulated subunit. 2 Hypoxia results in stabilization of HIF-1a, facilitating nuclear HIF-1a binding and restoration of oxygen homeostasis by inducing glycolysis and angiogenesis through upregulation of vascular endothelial growth

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Antibody Expressionsmentioning

confidence: 99%

Section: Myometrial Invasionmentioning

confidence: 99%

mentioning

confidence: 99%

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Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

et al. 2007

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Absence of Planned Neck Dissection for the N2-N3 Neck After Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Lau

Phan²,

MacKinnon³

et al. 2008

Arch Otolaryngol Head Neck Surg

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In these patients with locally advanced SCCHN and N2-N3 neck disease treated with chemoradiation and achieving CR, only a few patients with N2 neck disease experienced recurrence despite the absence of planned ND. Prospective trials are needed to identify patients with N2 neck disease who may still benefit from planned ND after chemoradiation. There were not enough patients with N3 neck disease to make any recommendations.

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Review of methods used to study oxygen transport at the microcirculatory level

et al. 2000

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The existence of hypoxic regions in tumors has long been recognized as a key factor leading to radiation resistance. More recently, it has been found that low oxygen levels also affect drug resistance, angiogenesis, cytokine production, cell cycle control, apoptosis, and metastatic propensity of tumors. Until now, most approaches to eliminating hypoxia have been empirical. However, improved understanding of the underlying mechanisms may permit the development of more soundly based, effective approaches. As discussed in this review, critical evaluation of the factors governing oxygen transport in tumors requires a thorough understanding of the methods used to study this process. Many experimental methodologies can be used to address these issues. In this review, the emphasis is placed on techniques that measure parameters on the scale of the diffusion distance of oxygen. Studies at the microregional level provide the most detailed physiological information on such processes. Over the past few years, significant progress in technology has allowed us to measure tumor oxygenation, yet spatial and temporal heterogeneities continue to provide significant challenges to obtaining clear knowledge of oxygen transport. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 237–255 (2000). © 2000 Wiley‐Liss, Inc.

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Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome

Cited by 145 publications

References 0 publications

Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

Absence of Planned Neck Dissection for the N2-N3 Neck After Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Review of methods used to study oxygen transport at the microcirculatory level

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