Oxygenation equilibration time after alteration of inspired oxygen in critically ill patients

Fildissis, George; Katostaras, Theofanis; Moles, Athanassios; Katsaros, Andreas; Myrianthefs, Paylos; Brokalaki, Hero; Tsoumakas, Konstantinos; Baltopoulos, George

doi:10.1016/j.hrtlng.2009.06.009

Cited by 12 publications

(19 citation statements)

References 8 publications

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“…Furthermore, because our primary interest was changes in blood oxygen over time rather than absolute PaO 2 values, we feel that SpO 2 is a valid measurement. The pattern of SpO 2 fall that we observed in this study describes a curve that appears the same in shape to that plotted for PaO 2 decrement in other studies …”

Section: Discussionsupporting

confidence: 85%

“…SpO 2 versus time data for each subject were fitted to the following exponential decay model using a statistical computer program:

where SpO 2 (t) is SpO 2 at a certain point in time, SpO 2 i is the initial SpO 2 at the time of O 2 cessation, SpO 2 f is the final SpO 2 after equilibration breathing air and k is a time constant. This is the model used by Fildissis et al . with SpO 2 substituted for PaO 2 .…”

Section: Methodsmentioning

confidence: 99%

“…This makes it necessary to select a consistent mark to use as the definition of blood oxygen equilibration that is neither too early nor too late. The t90, which has been used previously, appears to fit this role It is given by the following equation:

…”

Section: Methodsmentioning

confidence: 99%

“…Studies by Solis et al . and Fildissis et al . assessed the time to PaO 2 equilibration after reductions or increases in fraction of inspired oxygen (FiO 2 ) in critically ill, mechanically ventilated patients.…”

Section: Introductionmentioning

confidence: 99%

“…3 Naughton et al found that PaO2 equilibrated within 5 min in nine patients with COPD undergoing normobaric and hypobaric hypoxia altitude simulation tests. 4 Studies by Solis et al 5 and Fildissis et al 6 assessed the time to PaO2 equilibration after reductions or increases in fraction of inspired oxygen (FiO2) in critically ill, mechanically ventilated patients. The former included seven patients with diffuse pneumonia in whom equilibration occurred within 10 min.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease

Stone

Wong

Barnes

2015

Internal Medicine Journal

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Section: Discussionsupporting

confidence: 85%

“…SpO 2 versus time data for each subject were fitted to the following exponential decay model using a statistical computer program:

Section: Methodsmentioning

confidence: 99%

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease

Stone

Wong

Barnes

2015

Internal Medicine Journal

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Time to reach a new steady state after changes of positive end expiratory pressure

et al. 2013

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Prediction of inspired oxygen fraction for targeted arterial oxygen tension following open heart surgery in non-smoking and smoking patients

Bou‐Khalil

Zeineldine

Chatburn

et al. 2016

J Clin Monit Comput

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Simple and accurate expressions describing the PO-FO relationship in mechanically ventilated patients are lacking. The current study aims to validate a novel mathematical expression for accurate prediction of the fraction of inspired oxygen that will result in a targeted arterial oxygen tension in non-smoking and smoking patients receiving mechanical ventilation following open heart surgeries. One hundred PO-FO data pairs were obtained from 25 non-smoking patients mechanically ventilated following open heart surgeries. One data pair was collected at each of FO of 40, 60, 80, and 100% while maintaining same mechanical ventilation support settings. Similarly, another 100 hundred PO-FO data pairs were obtained from 25 smoking patients mechanically ventilated following open heart surgeries. The utility of the new mathematical expression in accurately describing the PO-FO relationship in these patients was assessed by the regression and Bland-Altman analyses. Significant correlations were seen between the true and estimated FO values in non-smoking (r = 0.9424; p < 0.05) and smoking (r = 0.9466; p < 0.05) patients. Tight biases between the true and estimated FO values for non-smoking (3.1%) and smoking (4.1%) patients were observed. Also, significant correlations were seen between the true and estimated PO/FO ratios in non-smoking (r = 0.9530; p < 0.05) and smoking (r = 0.9675; p < 0.05) patients. Tight biases between the true and estimated PO/FO ratios for non-smoking (-18 mmHg) and smoking (-16 mmHg) patients were also observed. The new mathematical expression for the description of the PO-FO relationship is valid and accurate in non-smoking and smoking patients who are receiving mechanical ventilation for post cardiac surgery.

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Oxygenation equilibration time after alteration of inspired oxygen in critically ill patients

Cited by 12 publications

References 8 publications

Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease

Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease

Time to reach a new steady state after changes of positive end expiratory pressure

Prediction of inspired oxygen fraction for targeted arterial oxygen tension following open heart surgery in non-smoking and smoking patients

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