Oxygenated perfusion for liver preservation: a perfluorodecalin-UW emulsion is not feasible

Klar, E.; Kraus, T.; Reuter, P.; Mehrabi, Arianeb; Fernandes, L.; Angelescu, M; Gebhard, Martha Maria; Herfarth, Ch.

doi:10.1016/s0041-1345(98)01204-4

Cited by 4 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, these techniques were not translated successfully to the porcine liver with a report of increased intravascular resistance during perfusion [115]. In this report the authors concluded that possible causes related to the high instability of the PFC-based solution, causing complement activation leading to an increased leucocyte adhesion and further macromolecules or that the perfusion technique itself caused injury (a strong vasoconstriction caused by the inflow of cold PDF-UW emulsion) [115, 116]. In recenting study, used oxycyte, a PFC added to UW solution can be beneficial after cardiac death liver graft preservation in a rat model [111].…”

Section: Strategies Applied In Experimental Models Of Hepatic I/rmentioning

confidence: 99%

The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models

Mendes‐Braz

Elias-Miró

Jiménez‐Castro

et al. 2012

Journal of Biomedicine and Biotechnology

135

107

View full text Add to dashboard Cite

The present review focuses on the numerous experimental models used to study the complexity of hepatic ischemia/reperfusion (I/R) injury. Although experimental models of hepatic I/R injury represent a compromise between the clinical reality and experimental simplification, the clinical transfer of experimental results is problematic because of anatomical and physiological differences and the inevitable simplification of experimental work. In this review, the strengths and limitations of the various models of hepatic I/R are discussed. Several strategies to protect the liver from I/R injury have been developed in animal models and, some of these, might find their way into clinical practice. We also attempt to highlight the fact that the mechanisms responsible for hepatic I/R injury depend on the experimental model used, and therefore the therapeutic strategies also differ according to the model used. Thus, the choice of model must therefore be adapted to the clinical question being answered.

show abstract

Section: Strategies Applied In Experimental Models Of Hepatic I/rmentioning

confidence: 99%

The Current State of Knowledge of Hepatic Ischemia-Reperfusion Injury Based on Its Study in Experimental Models

Mendes‐Braz

Elias-Miró

Jiménez‐Castro

et al. 2012

Journal of Biomedicine and Biotechnology

135

107

View full text Add to dashboard Cite

show abstract

“…We hypothesized that the vascular flush as routinely performed during organ procurement can cover the requirements for both effective tissue preservation and oxygen supply of large organs, if organ preservation solutions combine a high oxygendissolving capacity with characteristics of HTK or UWS, vital to prevent cell swelling and maintain tissue viability during cold storage (Belzer and Southard, 1988). However, the chemical requirements to manufacture stable emulsions including a significant percentage of oxygen carrier clearly favour the utilization of semifluorinated alkanes such as F6H8 or F6H10 which possess amphiphilic characteristics in contrast to PFD (Klar et al, 1998, Voiglio et al, 1996.…”

Section: Fig 4 Chemical Structure Of Perfluorohexyloctan (F6h8)mentioning

confidence: 99%